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The map label for this gene is hepT [H]

Identifier: 134300012

GI number: 134300012

Start: 2370308

End: 2371270

Strand: Reverse

Name: hepT [H]

Synonym: Dred_2166

Alternate gene names: 134300012

Gene position: 2371270-2370308 (Counterclockwise)

Preceding gene: 134300014

Following gene: 134300011

Centisome position: 65.72

GC content: 43.09

Gene sequence:

>963_bases
ATGCTCGATTTTTTTAGCCAGGTTAGGAAAGATCTTCAGGTTGTTGAGCATGAAATAAAAACCATCGTTCAGTCCCGAGA
TCCGCTTTTAACCCAAACCTCAATTCATTTATTAAATGCCGGCGGAAAACGTTTACGTCCGGCTTTTGCGCTTTTGGCAG
GTAAGTTCTATCATTATAGCTTAGAAAAGCTTTTACCTTTGGCAGTTGCATTGGAACTTATTCACATGGCCACTCTGGTA
CATGATGATGTGGTGGATGACTCCCTAACCAGAAGGGGTACCCCCACCGTTAAAGCCAATTGGGGCAATCGAATCTCCAT
GCATACAGGAGATTACCTGTTTGCCAAATCACTGGTACTGATTTCTCAATATGAGAACCCATTAATTGCTCAGGTACTGG
CTGATACCAGTGTCATGATGTGCGAAGGTGAAATGCACCAAATTTCAACAGCCTATAGTGCGGAACAAAGTTGGAGGGAC
TATTTCTATCGGATCAAACGAAAGACAGCTTTATTAATTGCGGCCAGTTGCCAATTAGGCGCGGTGGCGGTGGGAGCACC
AGAGGAAGAGTACAAGAACCTTAGAAGATATGGGCACCATCTCGGTATGGCCTTTCAAATTACGGATGATATTCTAGACA
TGGTGGCTGACCAGAGTCTTCTTGGCAAACCCATTGGCGGTGATTTGCGCCAGGGAATTTTGACCATGCCAGTGATATAC
TCTTTGGAAAGAAGCCCTCAAAGAACACGCCTGCGCCAATTGGTGGAAATTGAAGAAAAAACGGACGAGCAGGTAAAAGA
AGCCATTGAAATTATTAAAGAAGCTGGCGGTATTGAGTATGCATTTAATGCCACAAAGCAATATATCGAAAAAGCCAAGA
AAAACTTAACTCATCTTCCCAATAAGCCAGTTAAAGAAACCTTTTATCAGATTGCTGATTTTATCGGTATTCGGAGGTTC
TAA

Upstream 100 bases:

>100_bases
CCCCTGTATTGTTTAATAAGGGAGGAATTCTTTAACTACTGGCGAATATTTACCAGTTGTGGTAGTAAGATAAGTTTTGC
GAGTAGGTGACAGATAATAT

Downstream 100 bases:

>100_bases
ATAGATCTAGATGACTAATTTATATCCTGTTTTTCTGAATTTAGAAAACTGCCTCTGCCTAGTTGTGGGTGGTGGACAAG
TGGCAGAACGAAAAATTCAT

Product: trans-hexaprenyltranstransferase

Products: NA

Alternate protein names: HEPPP synthase subunit 2; Spore germination protein C3 [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MLDFFSQVRKDLQVVEHEIKTIVQSRDPLLTQTSIHLLNAGGKRLRPAFALLAGKFYHYSLEKLLPLAVALELIHMATLV
HDDVVDDSLTRRGTPTVKANWGNRISMHTGDYLFAKSLVLISQYENPLIAQVLADTSVMMCEGEMHQISTAYSAEQSWRD
YFYRIKRKTALLIAASCQLGAVAVGAPEEEYKNLRRYGHHLGMAFQITDDILDMVADQSLLGKPIGGDLRQGILTMPVIY
SLERSPQRTRLRQLVEIEEKTDEQVKEAIEIIKEAGGIEYAFNATKQYIEKAKKNLTHLPNKPVKETFYQIADFIGIRRF

Sequences:

>Translated_320_residues
MLDFFSQVRKDLQVVEHEIKTIVQSRDPLLTQTSIHLLNAGGKRLRPAFALLAGKFYHYSLEKLLPLAVALELIHMATLV
HDDVVDDSLTRRGTPTVKANWGNRISMHTGDYLFAKSLVLISQYENPLIAQVLADTSVMMCEGEMHQISTAYSAEQSWRD
YFYRIKRKTALLIAASCQLGAVAVGAPEEEYKNLRRYGHHLGMAFQITDDILDMVADQSLLGKPIGGDLRQGILTMPVIY
SLERSPQRTRLRQLVEIEEKTDEQVKEAIEIIKEAGGIEYAFNATKQYIEKAKKNLTHLPNKPVKETFYQIADFIGIRRF
>Mature_320_residues
MLDFFSQVRKDLQVVEHEIKTIVQSRDPLLTQTSIHLLNAGGKRLRPAFALLAGKFYHYSLEKLLPLAVALELIHMATLV
HDDVVDDSLTRRGTPTVKANWGNRISMHTGDYLFAKSLVLISQYENPLIAQVLADTSVMMCEGEMHQISTAYSAEQSWRD
YFYRIKRKTALLIAASCQLGAVAVGAPEEEYKNLRRYGHHLGMAFQITDDILDMVADQSLLGKPIGGDLRQGILTMPVIY
SLERSPQRTRLRQLVEIEEKTDEQVKEAIEIIKEAGGIEYAFNATKQYIEKAKKNLTHLPNKPVKETFYQIADFIGIRRF

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=323, Percent_Identity=25.3869969040248, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4758430, Length=266, Percent_Identity=22.5563909774436, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI83700220, Length=266, Percent_Identity=22.5563909774436, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI169808399, Length=271, Percent_Identity=23.6162361623616, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1789578, Length=312, Percent_Identity=31.0897435897436, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786623, Length=241, Percent_Identity=31.1203319502075, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=292, Percent_Identity=31.1643835616438, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=28.1879194630872, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325188, Length=288, Percent_Identity=21.1805555555556, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651612, Length=315, Percent_Identity=28.2539682539683, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281365769, Length=296, Percent_Identity=23.3108108108108, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660002, Length=296, Percent_Identity=23.3108108108108, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36323; Mature: 36323

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFFSQVRKDLQVVEHEIKTIVQSRDPLLTQTSIHLLNAGGKRLRPAFALLAGKFYHYS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LEKLLPLAVALELIHMATLVHDDVVDDSLTRRGTPTVKANWGNRISMHTGDYLFAKSLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCHHHHHHHHH
ISQYENPLIAQVLADTSVMMCEGEMHQISTAYSAEQSWRDYFYRIKRKTALLIAASCQLG
HHHCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
AVAVGAPEEEYKNLRRYGHHLGMAFQITDDILDMVADQSLLGKPIGGDLRQGILTMPVIY
EEEECCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHH
SLERSPQRTRLRQLVEIEEKTDEQVKEAIEIIKEAGGIEYAFNATKQYIEKAKKNLTHLP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCC
NKPVKETFYQIADFIGIRRF
CCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDFFSQVRKDLQVVEHEIKTIVQSRDPLLTQTSIHLLNAGGKRLRPAFALLAGKFYHYS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LEKLLPLAVALELIHMATLVHDDVVDDSLTRRGTPTVKANWGNRISMHTGDYLFAKSLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCHHHHHHHHH
ISQYENPLIAQVLADTSVMMCEGEMHQISTAYSAEQSWRDYFYRIKRKTALLIAASCQLG
HHHCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
AVAVGAPEEEYKNLRRYGHHLGMAFQITDDILDMVADQSLLGKPIGGDLRQGILTMPVIY
EEEECCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHH
SLERSPQRTRLRQLVEIEEKTDEQVKEAIEIIKEAGGIEYAFNATKQYIEKAKKNLTHLP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCC
NKPVKETFYQIADFIGIRRF
CCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 2121900; 9720033 [H]