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The map label for this gene is cysG [H]

Identifier: 134300011

GI number: 134300011

Start: 2369656

End: 2370228

Strand: Reverse

Name: cysG [H]

Synonym: Dred_2165

Alternate gene names: 134300011

Gene position: 2370228-2369656 (Counterclockwise)

Preceding gene: 134300012

Following gene: 134300010

Centisome position: 65.69

GC content: 44.68

Gene sequence:

>573_bases
GTGGCAGAACGAAAAATTCATGCACTGCTGGAGTGTGGTGCCTCAGTCAGAGTGGTAAGCCCAAAAGTTACTCCCCTTAT
AAAAGAGTGGTCCGATGAAGGCCGATTGGAACTCCGACAAAGGCACTACCAAACCTTTGATCTGGAAGGATCATTTTTGG
TCTTTGCTGCCACAAACAGTTCCCGGGTCAATCATCGTGTGACCGAGGACTGCAGGAAGGGGCATCTGGCAGTGAATATT
GCAGACGACCCATCCAATAGTAACTTTTTTGTGCCTTCTGTGATTAGAAGGGGCAAACTTTCCATTGCTGTATCAACCAG
TGGGGCCAGTCCCCTGCTGGCTGCCAAGATAAGGCGGCAATTGGAAAAGCAATTTGGCACGGAGTATGAAGAGTTTGCAG
ATGTCCTTACGGAAGTACGAAATCAGGTACTTAATGACATTGAAGATATTCATGCAAGAAGGACTATATTTAAGAAATTA
GTGGAATCTGACATTTTAGAATTACTGAGAGAGAAAAAGTACGACCAGGTAAAGGAGCGCATTAAAAATGCTTATTGCGG
TTATCGGAGTTAA

Upstream 100 bases:

>100_bases
ATCGGTATTCGGAGGTTCTAAATAGATCTAGATGACTAATTTATATCCTGTTTTTCTGAATTTAGAAAACTGCCTCTGCC
TAGTTGTGGGTGGTGGACAA

Downstream 100 bases:

>100_bases
CCACCGCACTGCCCCCCTTGAAGTGCGAGAGAAACTTGCTTTTACTGAATGGGGTATGAAAGATTCGTTGAAAAGACTAA
TGTCTTATCCAGGCATTGAC

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAERKIHALLECGASVRVVSPKVTPLIKEWSDEGRLELRQRHYQTFDLEGSFLVFAATNSSRVNHRVTEDCRKGHLAVNI
ADDPSNSNFFVPSVIRRGKLSIAVSTSGASPLLAAKIRRQLEKQFGTEYEEFADVLTEVRNQVLNDIEDIHARRTIFKKL
VESDILELLREKKYDQVKERIKNAYCGYRS

Sequences:

>Translated_190_residues
MAERKIHALLECGASVRVVSPKVTPLIKEWSDEGRLELRQRHYQTFDLEGSFLVFAATNSSRVNHRVTEDCRKGHLAVNI
ADDPSNSNFFVPSVIRRGKLSIAVSTSGASPLLAAKIRRQLEKQFGTEYEEFADVLTEVRNQVLNDIEDIHARRTIFKKL
VESDILELLREKKYDQVKERIKNAYCGYRS
>Mature_189_residues
AERKIHALLECGASVRVVSPKVTPLIKEWSDEGRLELRQRHYQTFDLEGSFLVFAATNSSRVNHRVTEDCRKGHLAVNIA
DDPSNSNFFVPSVIRRGKLSIAVSTSGASPLLAAKIRRQLEKQFGTEYEEFADVLTEVRNQVLNDIEDIHARRTIFKKLV
ESDILELLREKKYDQVKERIKNAYCGYRS

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=164, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 21749; Mature: 21618

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERKIHALLECGASVRVVSPKVTPLIKEWSDEGRLELRQRHYQTFDLEGSFLVFAATNS
CCCHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHEECCCCCEEEEEECCC
SRVNHRVTEDCRKGHLAVNIADDPSNSNFFVPSVIRRGKLSIAVSTSGASPLLAAKIRRQ
CHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
LEKQFGTEYEEFADVLTEVRNQVLNDIEDIHARRTIFKKLVESDILELLREKKYDQVKER
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNAYCGYRS
HHHHCCCCCC
>Mature Secondary Structure 
AERKIHALLECGASVRVVSPKVTPLIKEWSDEGRLELRQRHYQTFDLEGSFLVFAATNS
CCHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHEECCCCCEEEEEECCC
SRVNHRVTEDCRKGHLAVNIADDPSNSNFFVPSVIRRGKLSIAVSTSGASPLLAAKIRRQ
CHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
LEKQFGTEYEEFADVLTEVRNQVLNDIEDIHARRTIFKKLVESDILELLREKKYDQVKER
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNAYCGYRS
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA