Click here to switch to the map view.

The map label for this gene is hemL

Identifier: 134300002

GI number: 134300002

Start: 2360245

End: 2361543

Strand: Reverse

Name: hemL

Synonym: Dred_2156

Alternate gene names: 134300002

Gene position: 2361543-2360245 (Counterclockwise)

Preceding gene: 134300003

Following gene: 134300001

Centisome position: 65.45

GC content: 48.65

Gene sequence:

>1299_bases
ATGGCTCCCAGCTACCAAAAATCAGAGGAAATGTTTGAACAAGCCCAAAGGATTATCCCTGGCGGTGTAAACAGCCCCGT
ACGAGCCTTTAAATCCGTAGGGATGAACCCACCCTTCATTGCTAGGGCTAATGGTTCCCGTATGTGGGACGTGGATGGCA
ATGAATATATCGACTATATTTGTTCCTGGGGACCGCAGATTCTAGGACATCGTCACCCTGCGGTGATTCACGCCCTTCAA
GACTGCTTAGAGAAAGGAACCACCTATGGGGCTCCTACGGATCTGGAGGTAACCCTGGCTCAAATGTTGACAGAGGCATT
ACCATCGGTGGAAATGGTTCGCATGGTGAACTCTGGTACAGAGGCAACCATGAGTGCCCTGCGCTTAGCCCGAGCCTATA
CAAATCGAAGCAAAATTATAAAATTTGAAGGCTGTTACCATGGCCACCATGATTCCCTTTTGATTAAAGCCGGTTCAGGA
GCCCTTACCCATGGTGTTCCCACCAGCCCAGGGGTGCCAGAAAACATTGCCAGCAATACAATTAATGCACGTTATAATGA
TCTGGAATTGTTGGAGAAGATCTTTACTGAAGTGGGTTCGGATATAGCAGCTATTATTGTGGAACCCTTAGCAGGAAATA
TGGGGGTTGTTCCTCCAGCAGAGGGTTTTCTGCAGGGACTAAGGGACCTTTGTAACAAACATAGTGCCCTGTTAATTTTT
GATGAAGTTATTACAGGTTTCCGCTTAAGTTATGGGGGTGCTCAGGCCTATTATAATGTTATGCCTGATTTAACCTGCCT
GGGTAAAATCATAGGTGGCGGGTTACCTGTGGGGGCATACGGTGGCCGCAGGGAGATTATGCAGATGGTTTCTCCTGCGG
GTCCGGTGTACCAGGCAGGAACGCTTTCCGGCAATCCTTTGGCGATGACTGCGGGTATCGCAACCCTTAAGCAATTACAG
CAACCGGGTGTTTATGAAGAGCTTGATTACAAGTCAGACCTCCTGGCCCAGGGTTTGATTCAAGCTGCGAAAGCGGCTGG
TGTGGAGGCATCCTTTAACCGGGTACAATCCTTGCAAACCTGTTTCTTCACCCAGCAGGATGTAAGGGACTTCGCCACAG
CTTCCTCCTCTGATACCAAGCAGTATGCAGCCTTCTTTAGAAACATGTTGGAGCAGGGTATTTACCTGGCACCTGCACAG
TTTGAAGCAACCTTTGTTTCATTGGCCCATACTGAGAATGATATAGAGCGTACAGTGGAAGCGGCCTTTAACGCCTTTAG
GGCTGCTGCAAAGGAATAA

Upstream 100 bases:

>100_bases
CTTTCAGAGATTGCCGGTGTCACAAATTATCGCTTGCTCTACAGTGTAACAGAATTAAAGAAAAGCAGCATGAAATATTT
CATGGATTAGGAGGTACCTA

Downstream 100 bases:

>100_bases
ATTTTACAAAAGGATAGGTCAGGCCCTATCCTTTTGTTGTATAAAAATAATCCATATTACGAAAAATATATGTATCAGGA
GGAAAGATGTTATGATTATC

Product: glutamate-1-semialdehyde-2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MAPSYQKSEEMFEQAQRIIPGGVNSPVRAFKSVGMNPPFIARANGSRMWDVDGNEYIDYICSWGPQILGHRHPAVIHALQ
DCLEKGTTYGAPTDLEVTLAQMLTEALPSVEMVRMVNSGTEATMSALRLARAYTNRSKIIKFEGCYHGHHDSLLIKAGSG
ALTHGVPTSPGVPENIASNTINARYNDLELLEKIFTEVGSDIAAIIVEPLAGNMGVVPPAEGFLQGLRDLCNKHSALLIF
DEVITGFRLSYGGAQAYYNVMPDLTCLGKIIGGGLPVGAYGGRREIMQMVSPAGPVYQAGTLSGNPLAMTAGIATLKQLQ
QPGVYEELDYKSDLLAQGLIQAAKAAGVEASFNRVQSLQTCFFTQQDVRDFATASSSDTKQYAAFFRNMLEQGIYLAPAQ
FEATFVSLAHTENDIERTVEAAFNAFRAAAKE

Sequences:

>Translated_432_residues
MAPSYQKSEEMFEQAQRIIPGGVNSPVRAFKSVGMNPPFIARANGSRMWDVDGNEYIDYICSWGPQILGHRHPAVIHALQ
DCLEKGTTYGAPTDLEVTLAQMLTEALPSVEMVRMVNSGTEATMSALRLARAYTNRSKIIKFEGCYHGHHDSLLIKAGSG
ALTHGVPTSPGVPENIASNTINARYNDLELLEKIFTEVGSDIAAIIVEPLAGNMGVVPPAEGFLQGLRDLCNKHSALLIF
DEVITGFRLSYGGAQAYYNVMPDLTCLGKIIGGGLPVGAYGGRREIMQMVSPAGPVYQAGTLSGNPLAMTAGIATLKQLQ
QPGVYEELDYKSDLLAQGLIQAAKAAGVEASFNRVQSLQTCFFTQQDVRDFATASSSDTKQYAAFFRNMLEQGIYLAPAQ
FEATFVSLAHTENDIERTVEAAFNAFRAAAKE
>Mature_431_residues
APSYQKSEEMFEQAQRIIPGGVNSPVRAFKSVGMNPPFIARANGSRMWDVDGNEYIDYICSWGPQILGHRHPAVIHALQD
CLEKGTTYGAPTDLEVTLAQMLTEALPSVEMVRMVNSGTEATMSALRLARAYTNRSKIIKFEGCYHGHHDSLLIKAGSGA
LTHGVPTSPGVPENIASNTINARYNDLELLEKIFTEVGSDIAAIIVEPLAGNMGVVPPAEGFLQGLRDLCNKHSALLIFD
EVITGFRLSYGGAQAYYNVMPDLTCLGKIIGGGLPVGAYGGRREIMQMVSPAGPVYQAGTLSGNPLAMTAGIATLKQLQQ
PGVYEELDYKSDLLAQGLIQAAKAAGVEASFNRVQSLQTCFFTQQDVRDFATASSSDTKQYAAFFRNMLEQGIYLAPAQF
EATFVSLAHTENDIERTVEAAFNAFRAAAKE

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=320, Percent_Identity=31.5625, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI24119277, Length=340, Percent_Identity=29.1176470588235, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI284507298, Length=240, Percent_Identity=32.9166666666667, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI37574042, Length=299, Percent_Identity=29.0969899665552, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI226442705, Length=298, Percent_Identity=28.1879194630872, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442709, Length=267, Percent_Identity=28.4644194756554, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=56.1611374407583, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1788044, Length=312, Percent_Identity=34.9358974358974, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789016, Length=349, Percent_Identity=31.2320916905444, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI145693181, Length=307, Percent_Identity=33.8762214983713, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=302, Percent_Identity=32.7814569536424, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1787560, Length=381, Percent_Identity=29.1338582677165, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786991, Length=293, Percent_Identity=27.3037542662116, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=325, Percent_Identity=30.1538461538462, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=322, Percent_Identity=29.5031055900621, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=158, Percent_Identity=38.6075949367089, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=330, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=326, Percent_Identity=28.5276073619632, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=316, Percent_Identity=30.0632911392405, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21356575, Length=325, Percent_Identity=30.1538461538462, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_DESRM (A4J6H0)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113498.1
- ProteinModelPortal:   A4J6H0
- SMR:   A4J6H0
- STRING:   A4J6H0
- GeneID:   4958261
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2156
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- PhylomeDB:   A4J6H0
- BioCyc:   DRED349161:DRED_2156-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46689; Mature: 46557

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSYQKSEEMFEQAQRIIPGGVNSPVRAFKSVGMNPPFIARANGSRMWDVDGNEYIDYI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHHH
CSWGPQILGHRHPAVIHALQDCLEKGTTYGAPTDLEVTLAQMLTEALPSVEMVRMVNSGT
HHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCH
EATMSALRLARAYTNRSKIIKFEGCYHGHHDSLLIKAGSGALTHGVPTSPGVPENIASNT
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHCC
INARYNDLELLEKIFTEVGSDIAAIIVEPLAGNMGVVPPAEGFLQGLRDLCNKHSALLIF
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEH
DEVITGFRLSYGGAQAYYNVMPDLTCLGKIIGGGLPVGAYGGRREIMQMVSPAGPVYQAG
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMTAGIATLKQLQQPGVYEELDYKSDLLAQGLIQAAKAAGVEASFNRVQSLQT
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CFFTQQDVRDFATASSSDTKQYAAFFRNMLEQGIYLAPAQFEATFVSLAHTENDIERTVE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHH
AAFNAFRAAAKE
HHHHHHHHHHCC
>Mature Secondary Structure 
APSYQKSEEMFEQAQRIIPGGVNSPVRAFKSVGMNPPFIARANGSRMWDVDGNEYIDYI
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHHH
CSWGPQILGHRHPAVIHALQDCLEKGTTYGAPTDLEVTLAQMLTEALPSVEMVRMVNSGT
HHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCH
EATMSALRLARAYTNRSKIIKFEGCYHGHHDSLLIKAGSGALTHGVPTSPGVPENIASNT
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHCC
INARYNDLELLEKIFTEVGSDIAAIIVEPLAGNMGVVPPAEGFLQGLRDLCNKHSALLIF
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEH
DEVITGFRLSYGGAQAYYNVMPDLTCLGKIIGGGLPVGAYGGRREIMQMVSPAGPVYQAG
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMTAGIATLKQLQQPGVYEELDYKSDLLAQGLIQAAKAAGVEASFNRVQSLQT
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CFFTQQDVRDFATASSSDTKQYAAFFRNMLEQGIYLAPAQFEATFVSLAHTENDIERTVE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHH
AAFNAFRAAAKE
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA