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The map label for this gene is proH [H]

Identifier: 134299031

GI number: 134299031

Start: 1241297

End: 1242142

Strand: Reverse

Name: proH [H]

Synonym: Dred_1168

Alternate gene names: 134299031

Gene position: 1242142-1241297 (Counterclockwise)

Preceding gene: 134299032

Following gene: 134299011

Centisome position: 34.43

GC content: 44.92

Gene sequence:

>846_bases
ATGTTAGAAGGAAAAACCTTTTTTTTCGTCGGTGCCGGTAATATTTGCGAATCTATGATAAAAGGAATTTTATCCGCTGG
GATCGTACGTCCCGGTGAGATCCGTGTTGCAAACCGCAGTAACACTGAGCGTTTAAACTATCTACGTAACTACTATGGTA
TTGTTCCTGTTACAGATAAGCAAACCGCCGCTGCCAAAGCTGATATTATTGTCTTGGCAATGAAACCCCAGGATGTATTT
GCCGCCTTGGATGAGCTTAGGGATAGCACTCAAGAAAACCAAATTATCATTTCTGTCCTGGCAGGTGTACCCACTTCACT
CATTGAAGATAGTCTAAATACGCAAATTGCCGTTATCCGGGCCATGCCTAATACTTCCTGTGCCATACTGGAGTCTGCTA
CGGGTCTTAGTGCCGGTCGCTTTACCACTCCGAATCAACTTAAGTTAGCCGAAGAGATTTTTTGCATGATGGGTGAAGTT
GTTGTTGTCGAAGAACATCTATTGGATGCTGTTACAGGCCTTTCCGGCAGTGGCCCCGCTTACATTTATTATTTAGTAGA
AGCCATGGAAAAAGCCGGCGAGACCGCCGGCATACCCAGAGAACTGGCCCGCCCCCTGGTTTTAAAAACTTTATTGGGTG
CAGCAAAAATGCTTATGGAGACAGGTGAAAACCCCGAAGAACTGAGACGTCAGGTCACTTCACCAAACGGAACTACCATG
GCAGGCATTAATGAATTAAATAAGGGAGACTTCCAAAACACCCTCCGTAAAGCAATTCTTAAAGCCACCCGTCGTTCCCA
AGAACTGGGGCGGGTTATTATTGAGAAACAATATGCTCAAAAATAA

Upstream 100 bases:

>100_bases
ACATGCCCGGGGTCCTATGGGTCTCCGGGAACTAACCAGCTATAAATACGTTGTAAAAGGAACCGGCCAGGTCCGTCCAT
AATGTTAGGAGGTTATAGTA

Downstream 100 bases:

>100_bases
TCTGCCAAGATTAAAATCCTCCTGTTAAACATATGCTAATAGCAGGAGGTGAGTTGACATAACAGATAAACTTACCAAAG
AACTAAAAGAACCCGCTCAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 1; P5CR 1 [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLEGKTFFFVGAGNICESMIKGILSAGIVRPGEIRVANRSNTERLNYLRNYYGIVPVTDKQTAAAKADIIVLAMKPQDVF
AALDELRDSTQENQIIISVLAGVPTSLIEDSLNTQIAVIRAMPNTSCAILESATGLSAGRFTTPNQLKLAEEIFCMMGEV
VVVEEHLLDAVTGLSGSGPAYIYYLVEAMEKAGETAGIPRELARPLVLKTLLGAAKMLMETGENPEELRRQVTSPNGTTM
AGINELNKGDFQNTLRKAILKATRRSQELGRVIIEKQYAQK

Sequences:

>Translated_281_residues
MLEGKTFFFVGAGNICESMIKGILSAGIVRPGEIRVANRSNTERLNYLRNYYGIVPVTDKQTAAAKADIIVLAMKPQDVF
AALDELRDSTQENQIIISVLAGVPTSLIEDSLNTQIAVIRAMPNTSCAILESATGLSAGRFTTPNQLKLAEEIFCMMGEV
VVVEEHLLDAVTGLSGSGPAYIYYLVEAMEKAGETAGIPRELARPLVLKTLLGAAKMLMETGENPEELRRQVTSPNGTTM
AGINELNKGDFQNTLRKAILKATRRSQELGRVIIEKQYAQK
>Mature_281_residues
MLEGKTFFFVGAGNICESMIKGILSAGIVRPGEIRVANRSNTERLNYLRNYYGIVPVTDKQTAAAKADIIVLAMKPQDVF
AALDELRDSTQENQIIISVLAGVPTSLIEDSLNTQIAVIRAMPNTSCAILESATGLSAGRFTTPNQLKLAEEIFCMMGEV
VVVEEHLLDAVTGLSGSGPAYIYYLVEAMEKAGETAGIPRELARPLVLKTLLGAAKMLMETGENPEELRRQVTSPNGTTM
AGINELNKGDFQNTLRKAILKATRRSQELGRVIIEKQYAQK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=33.0909090909091, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI21361454, Length=265, Percent_Identity=34.7169811320755, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=31.5589353612167, Blast_Score=137, Evalue=7e-33,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=32.5842696629214, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=30.7407407407407, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=288, Percent_Identity=24.3055555555556, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=216, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648116, Length=272, Percent_Identity=32.3529411764706, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358587, Length=263, Percent_Identity=31.5589353612167, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=35.1190476190476, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30550; Mature: 30550

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEGKTFFFVGAGNICESMIKGILSAGIVRPGEIRVANRSNTERLNYLRNYYGIVPVTDK
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCEECCCC
QTAAAKADIIVLAMKPQDVFAALDELRDSTQENQIIISVLAGVPTSLIEDSLNTQIAVIR
HHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHCCCEEEEEE
AMPNTSCAILESATGLSAGRFTTPNQLKLAEEIFCMMGEVVVVEEHLLDAVTGLSGSGPA
ECCCCCCHHHECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
YIYYLVEAMEKAGETAGIPRELARPLVLKTLLGAAKMLMETGENPEELRRQVTSPNGTTM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEE
AGINELNKGDFQNTLRKAILKATRRSQELGRVIIEKQYAQK
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEGKTFFFVGAGNICESMIKGILSAGIVRPGEIRVANRSNTERLNYLRNYYGIVPVTDK
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCEECCCC
QTAAAKADIIVLAMKPQDVFAALDELRDSTQENQIIISVLAGVPTSLIEDSLNTQIAVIR
HHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHCCCEEEEEE
AMPNTSCAILESATGLSAGRFTTPNQLKLAEEIFCMMGEVVVVEEHLLDAVTGLSGSGPA
ECCCCCCHHHECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
YIYYLVEAMEKAGETAGIPRELARPLVLKTLLGAAKMLMETGENPEELRRQVTSPNGTTM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEE
AGINELNKGDFQNTLRKAILKATRRSQELGRVIIEKQYAQK
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1849493; 2493444 [H]