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The map label for this gene is proA

Identifier: 134299032

GI number: 134299032

Start: 1242161

End: 1243408

Strand: Reverse

Name: proA

Synonym: Dred_1169

Alternate gene names: 134299032

Gene position: 1243408-1242161 (Counterclockwise)

Preceding gene: 134299033

Following gene: 134299031

Centisome position: 34.46

GC content: 46.07

Gene sequence:

>1248_bases
ATGTCAAATGTAAAGAATCTGGCTAAAAAAGCTAAAATCGCCGCCAGGACACTATCTGTTTTGGATACAGAAGCTAAAAA
TTCTGCTTTAGAAGCCATTGCTTCTCAGTTACTTGCGGATAAAGAGACCATTCTACAGGCCAATGGAAAGGATTTAGACA
ATGGTAAAAAAATGGGTTTAAGTCCCTCCCTATTGGATCGGCTAGCCCTAACCTCTGCTCGCATTGATGGTATGGTGGAA
GGAATCAAGCAGGTCGTTGAATTAGAAGACCCCGTGGGGCAAGTTATGGAAACCTGGCAAAGACCCAATGGTTTAGAGAT
TGCCAAGGTTCGTGTACCCATGGGTGTCATTGGTATGGTCTACGAAGCCCGTCCTAACGTAACTGTAGATACCTGCGCCC
TATGTTTGAAGGCTGGCAGCGCTGTGGTACTAAGAGGAAGTTCCAGTGCTTTAAACAGTAATCGTGCTCTGGTGTCAGCC
ATTAAAAAAGGTCTTGCCAAAACTGCAATACCGGAAGATACCGTACAATTTGTTGATTCCGAGGACCGGGGAGCTGTGGA
TGAAATGCTTAGACTTAACGGTCTGTTGGATTTAGTTATTCCCAGAGGTGGTGCTGGCCTGATCCGAAGGGTGGTAGAAA
ATGCCACTGTGCCTGTTATTGAAACTGGTGTAGGTAACTGTCATGTGTATGTGGATGTGGATGCAGATCCAGGCATGGCC
CTTGAAATCCTACTGAATGCCAAATGCCAGCGGTATGGCGTATGCAATGCCGCAGAATCCCTGCTGGTTCATGAGGGAAT
TGCTGCAAATTGGCTCCCCGGAGCTGTGCAGGAACTAAACACACGTGGTGTGGAAATCCGAGGCTGCTCAAAGGTTGTTG
AAATCCTTTCAGGAGTTAAAAAAGCTGAAGATAGCGACTGGGCCACTGAATTTCTGTCCCCTGTATTAGCCATTAAAGTT
GTGAAAGATTTCCAGGATGCCCTGGATCATATCCAACAATACAGTTCCGGACATTCTGAAAGCATTGTAACCAATAACCA
AAATACCGCAGCAGAGTTTTTACGTCAGGTAGATGCAGCAGCAGTTTACCACAATGCATCAACCCGTTTTACCGATGGAT
TTGAGTATGGCTTTGGTGCAGAAATTGGTATCAGTACTCAAAAACTACATGCCCGGGGTCCTATGGGTCTCCGGGAACTA
ACCAGCTATAAATACGTTGTAAAAGGAACCGGCCAGGTCCGTCCATAA

Upstream 100 bases:

>100_bases
ACCTTTCTTCTGAGGATTTACGCCTTGTTAACAAAAATACACGTCACGGATTGGAAGTTATTAATCGGGACTGGTTAGTC
TGTGAAAGGGGTTTTTCTAT

Downstream 100 bases:

>100_bases
TGTTAGGAGGTTATAGTAATGTTAGAAGGAAAAACCTTTTTTTTCGTCGGTGCCGGTAATATTTGCGAATCTATGATAAA
AGGAATTTTATCCGCTGGGA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSNVKNLAKKAKIAARTLSVLDTEAKNSALEAIASQLLADKETILQANGKDLDNGKKMGLSPSLLDRLALTSARIDGMVE
GIKQVVELEDPVGQVMETWQRPNGLEIAKVRVPMGVIGMVYEARPNVTVDTCALCLKAGSAVVLRGSSSALNSNRALVSA
IKKGLAKTAIPEDTVQFVDSEDRGAVDEMLRLNGLLDLVIPRGGAGLIRRVVENATVPVIETGVGNCHVYVDVDADPGMA
LEILLNAKCQRYGVCNAAESLLVHEGIAANWLPGAVQELNTRGVEIRGCSKVVEILSGVKKAEDSDWATEFLSPVLAIKV
VKDFQDALDHIQQYSSGHSESIVTNNQNTAAEFLRQVDAAAVYHNASTRFTDGFEYGFGAEIGISTQKLHARGPMGLREL
TSYKYVVKGTGQVRP

Sequences:

>Translated_415_residues
MSNVKNLAKKAKIAARTLSVLDTEAKNSALEAIASQLLADKETILQANGKDLDNGKKMGLSPSLLDRLALTSARIDGMVE
GIKQVVELEDPVGQVMETWQRPNGLEIAKVRVPMGVIGMVYEARPNVTVDTCALCLKAGSAVVLRGSSSALNSNRALVSA
IKKGLAKTAIPEDTVQFVDSEDRGAVDEMLRLNGLLDLVIPRGGAGLIRRVVENATVPVIETGVGNCHVYVDVDADPGMA
LEILLNAKCQRYGVCNAAESLLVHEGIAANWLPGAVQELNTRGVEIRGCSKVVEILSGVKKAEDSDWATEFLSPVLAIKV
VKDFQDALDHIQQYSSGHSESIVTNNQNTAAEFLRQVDAAAVYHNASTRFTDGFEYGFGAEIGISTQKLHARGPMGLREL
TSYKYVVKGTGQVRP
>Mature_414_residues
SNVKNLAKKAKIAARTLSVLDTEAKNSALEAIASQLLADKETILQANGKDLDNGKKMGLSPSLLDRLALTSARIDGMVEG
IKQVVELEDPVGQVMETWQRPNGLEIAKVRVPMGVIGMVYEARPNVTVDTCALCLKAGSAVVLRGSSSALNSNRALVSAI
KKGLAKTAIPEDTVQFVDSEDRGAVDEMLRLNGLLDLVIPRGGAGLIRRVVENATVPVIETGVGNCHVYVDVDADPGMAL
EILLNAKCQRYGVCNAAESLLVHEGIAANWLPGAVQELNTRGVEIRGCSKVVEILSGVKKAEDSDWATEFLSPVLAIKVV
KDFQDALDHIQQYSSGHSESIVTNNQNTAAEFLRQVDAAAVYHNASTRFTDGFEYGFGAEIGISTQKLHARGPMGLRELT
SYKYVVKGTGQVRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=34.7826086956522, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=34.7826086956522, Blast_Score=255, Evalue=4e-68,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=45.5421686746988, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=35.024154589372, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=35.024154589372, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=37.8752886836028, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=36.4303178484108, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_DESRM (A4J3Q0)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001112528.1
- ProteinModelPortal:   A4J3Q0
- SMR:   A4J3Q0
- STRING:   A4J3Q0
- GeneID:   4955621
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1169
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A4J3Q0
- BioCyc:   DRED349161:DRED_1169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44463; Mature: 44332

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVKNLAKKAKIAARTLSVLDTEAKNSALEAIASQLLADKETILQANGKDLDNGKKMGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SPSLLDRLALTSARIDGMVEGIKQVVELEDPVGQVMETWQRPNGLEIAKVRVPMGVIGMV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
YEARPNVTVDTCALCLKAGSAVVLRGSSSALNSNRALVSAIKKGLAKTAIPEDTVQFVDS
EECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCC
EDRGAVDEMLRLNGLLDLVIPRGGAGLIRRVVENATVPVIETGVGNCHVYVDVDADPGMA
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCE
LEILLNAKCQRYGVCNAAESLLVHEGIAANWLPGAVQELNTRGVEIRGCSKVVEILSGVK
EEHEECCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHH
KAEDSDWATEFLSPVLAIKVVKDFQDALDHIQQYSSGHSESIVTNNQNTAAEFLRQVDAA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHH
AVYHNASTRFTDGFEYGFGAEIGISTQKLHARGPMGLRELTSYKYVVKGTGQVRP
HHHCCCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
SNVKNLAKKAKIAARTLSVLDTEAKNSALEAIASQLLADKETILQANGKDLDNGKKMGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SPSLLDRLALTSARIDGMVEGIKQVVELEDPVGQVMETWQRPNGLEIAKVRVPMGVIGMV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
YEARPNVTVDTCALCLKAGSAVVLRGSSSALNSNRALVSAIKKGLAKTAIPEDTVQFVDS
EECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCC
EDRGAVDEMLRLNGLLDLVIPRGGAGLIRRVVENATVPVIETGVGNCHVYVDVDADPGMA
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCE
LEILLNAKCQRYGVCNAAESLLVHEGIAANWLPGAVQELNTRGVEIRGCSKVVEILSGVK
EEHEECCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHH
KAEDSDWATEFLSPVLAIKVVKDFQDALDHIQQYSSGHSESIVTNNQNTAAEFLRQVDAA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHH
AVYHNASTRFTDGFEYGFGAEIGISTQKLHARGPMGLRELTSYKYVVKGTGQVRP
HHHCCCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA