Click here to switch to the map view.

The map label for this gene is uvrB

Identifier: 126697177

GI number: 126697177

Start: 1561941

End: 1563980

Strand: Reverse

Name: uvrB

Synonym: P9301_18391

Alternate gene names: 126697177

Gene position: 1563980-1561941 (Counterclockwise)

Preceding gene: 126697178

Following gene: 126697174

Centisome position: 95.26

GC content: 33.68

Gene sequence:

>2040_bases
ATGAACAACTATAAGCTTCAAGCTCCTTACGAACCAAATGGAGATCAACCAGAAGCTATTAAAAAATTAGTTAAAGGGGT
AAATACTGGTAAAGAGTTTCAGACTCTTTTAGGAGCTACTGGAACTGGTAAAACATTTACTATTGCTAATGTAATTCAGC
AAACAGGAAGACCAGCACTTGTATTAGCCCATAACAAAACGTTAGCTGCACAACTATGTAATGAATTAAGGGAATTTTTC
CCAAAAAATGCTGTTGAGTACTTCATTTCTTATTACGATTATTATCAACCTGAAGCTTATGTACCTGTAAGTGATACTTA
CATAGCCAAAACGGCTTCAATTAATGAAGAAATAGATATGCTTAGGCATTCTGCAACACGCTCATTATTTGAAAGAAAAG
ATGTAATTGTTGTAGCCTCAATAAGTTGTATTTATGGTCTTGGTATACCGAGTGAGTATTTAAAAGCTGCAGTTAAATTT
GAAGTGGGAAAATCAATAAATCTACGTTCTTATTTAAGGTCTCTCGTTGAAAATCAATATACTAGAAATGATATTGAAAT
TACTAGAGGTAGATTCAGAATTAAAGGTGATGTTTTAGAAATCGGTCCAGCTTATGAGGATAGATTAATTAGAATCGAAT
TATTTGGTGACGAAGTCGAAGCTATTAGATATGTTGACCCTACTACAGGAGAAATACTTGAAAGTTTGGAACAAGTTAGC
GTTTACCCAGCGAAGCATTTTGTGACCCCAAAAGAAAGACTTGAGAGTGCAATAAGTGCAATTAGAAGTGAATTAAAAAC
TCAACTAGATAAATTTACATACGAAGGAAAATTATTAGAGGCTCAACGTCTAGAACAACGCACAAAATATGATTTAGAAA
TGCTCAAAGAGGTTGGTTATTGTAATGGCGTTGAGAATTATGCTCGTCATTTATCAGGCAGGGAGGAAGGTTCACCACCA
GAATGCTTAATAGATTACTTTCCCAAAGATTGGTTGTTGGTAGTTGATGAGAGTCATGTGACATGTCCTCAACTTCATGC
AATGTACAACGGTGATCAATCTAGAAAAAAAGTTCTAATAGATCATGGGTTTAGATTGCCCAGTGCTGCAGATAATAGAC
CTTTAAAATGTGAAGAGTTTTGGGAAAAATCAAAACAGACATTATTTATAAGTGCAACTCCGGGTCAATGGGAATTAGAT
CAATGTGATGGTGAATTTATTGAGCAAGTTATAAGACCAACTGGGGTATTAGATCCTGTAATTGATGTAAGACCTAGTGA
GGGCCAAATAGAAGATCTGTTATCTGAAATAAGAATTAGAGCTGAAAAGAATCAACGAGTGCTAGTGACAACACTTACCA
AGAGAATGGCTGAAGATCTAACTGATTTTTTATCTGAAAATAAAGTAAGAGTTAGATATTTGCATTCCGAAATCCATTCA
ATTGAAAGAATTGAAATTATTCAAGACCTCAGAATGGGCGAATATGATGTTTTGGTAGGAGTTAATTTATTAAGAGAGGG
ACTAGATCTTCCTGAAGTATCTCTAGTTGCCATTTTAGACGCTGATAAAGAAGGTTTTCTCAGAGCTGAAAGGTCATTGA
TTCAAACAATTGGAAGAGCTGCAAGACATGTTGAAGGTGTTGCCTTGCTTTATGCAGATAACTTCACAGATTCAATGAAA
AGAGCAATTTCTGAAACTGAAAGAAGAAGAACTATTCAAAAAAAATATAACCAAGTCAATGGTATTACTCCAAAACCTGC
AGGCAAAAAAATTGAAAATTCAATATTATCTTTTCTAGAACTTTCCAGAAAATTAGATGCTGGTGGTTTATCTAAAGATT
TAATAAATATAGTTAATAATAAAACTGACGCAATTCTCGGTTCCAGTGATAATCAATGTTTGCTCGAAGAATTGCCTGAC
TTAATAGAAAAGTTAGAAATTAAAATGAAAGATGCTGCAAAAGAGTTAAATTTTGAAGAAGCAGCAAATTTGAGGGATAG
AATCAAAAAATTAAGACAAAAATTGGCAAGAAATAATTAA

Upstream 100 bases:

>100_bases
CGATGATTGCGGTTGTTAGAGGTTTAAAAGAATCTTTGAAAAATTCAATAATTCGAGAAAAAATTTCTTAGTATAGCATT
ACCTTTTTGCTATTAGGTTG

Downstream 100 bases:

>100_bases
AAAGAAACTTATTTGTCTAATTCGAAATGATTATGAATCGCATTAACTGCTTTGTCGCAATCTTTTTCTAAGACAATACA
TGAAGTCCTGATTTCACTAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSYLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN

Sequences:

>Translated_679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSYLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN
>Mature_679_residues
MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
EVGKSINLRSYLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPP
ECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMK
RAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPD
LIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=56.6318926974665, Blast_Score=749, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PROM0 (A3PFD7)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092063.1
- ProteinModelPortal:   A3PFD7
- STRING:   A3PFD7
- GeneID:   4911161
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_18391
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   PMAR167546:P9301ORF_1880-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77318; Mature: 77318

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSYLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCDGEFIEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPDLIEKLEIKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNN
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSYLRSLVENQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
TRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVS
CCCCCEEECCEEEEECCEEECCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
VYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
CNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHEEEH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCDGEFIEQVIRPTGVLDPV
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCC
IDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
IERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTDSMKRAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLE
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPDLIEKLEIKMKDAAKELNFEE
HHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLARNN
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA