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The map label for this gene is cobH [H]

Identifier: 126697174

GI number: 126697174

Start: 1558449

End: 1559072

Strand: Reverse

Name: cobH [H]

Synonym: P9301_18361

Alternate gene names: 126697174

Gene position: 1559072-1558449 (Counterclockwise)

Preceding gene: 126697177

Following gene: 126697172

Centisome position: 94.96

GC content: 34.29

Gene sequence:

>624_bases
ATGGTAGTAGATCATCCAATTTTTTTGGAAAGCATCAGATTCATAAGATCTCATTTATTAGCCAATGATCTAAATTATTT
GGAAAAAAAAGTGTTAGAGAGATTAGTCCATACTTCAGGAGATTTTTCAGTTCAAAATCTAGTAAATTTTAGTGATGGTG
CTTGCGAAAAAGGGCTTCAGGCACTTAAAAATGGTGCTCCGATTTTAACTGATACTGATATGGCAGCAGCAGCAATAAAA
AATATGGCAGAAAATACTACTAGGAATAAAGTATTCACCGCTAGAATGTGGTTTGAAAAAAATAATCATACAAACTTAAC
TAAAACTGCATATGGCTTAAGTGAAGGCTGGAAGGAGTTATCCGCTATGAATTCTGGAGGTAAATCACCTATTGTAGTTA
TTGGCAGTTCGCCTACAGCGTTAACTTATTTAATTGATATTTTAGAAAATGCAAAAGATTTACCTAGTTTAATTATCGGA
ATGCCTGTTGGATTTATTGGAGTAGAGAAAAGCAAAAACAAACTTATTTCTACCGATCTTCCTAGAATTGTTTTGAATTC
AACTAGAGGAGGTGCTGCAATGGCAGCTGCTACGGTTAACGCCTTATTAAGGGAGACTCTTTAA

Upstream 100 bases:

>100_bases
TTGAGCATTTAAATCATTACCCCATAATATTTGTATTGGCATAATAGCTCAATAAAAATCATATATTAACTATGATTACT
TCTAACACAAATTAAATTTA

Downstream 100 bases:

>100_bases
AAAGTATTAATTTTATATAAACGTCAAAAATCTACTTAATATTATGATTTAACTTGTTATTTTCTTCTAAAGAATTTAAA
ACTGATTTTGCTTTTTCTAT

Product: putative precorrin-8X methylmutase CobH

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MVVDHPIFLESIRFIRSHLLANDLNYLEKKVLERLVHTSGDFSVQNLVNFSDGACEKGLQALKNGAPILTDTDMAAAAIK
NMAENTTRNKVFTARMWFEKNNHTNLTKTAYGLSEGWKELSAMNSGGKSPIVVIGSSPTALTYLIDILENAKDLPSLIIG
MPVGFIGVEKSKNKLISTDLPRIVLNSTRGGAAMAAATVNALLRETL

Sequences:

>Translated_207_residues
MVVDHPIFLESIRFIRSHLLANDLNYLEKKVLERLVHTSGDFSVQNLVNFSDGACEKGLQALKNGAPILTDTDMAAAAIK
NMAENTTRNKVFTARMWFEKNNHTNLTKTAYGLSEGWKELSAMNSGGKSPIVVIGSSPTALTYLIDILENAKDLPSLIIG
MPVGFIGVEKSKNKLISTDLPRIVLNSTRGGAAMAAATVNALLRETL
>Mature_207_residues
MVVDHPIFLESIRFIRSHLLANDLNYLEKKVLERLVHTSGDFSVQNLVNFSDGACEKGLQALKNGAPILTDTDMAAAAIK
NMAENTTRNKVFTARMWFEKNNHTNLTKTAYGLSEGWKELSAMNSGGKSPIVVIGSSPTALTYLIDILENAKDLPSLIIG
MPVGFIGVEKSKNKLISTDLPRIVLNSTRGGAAMAAATVNALLRETL

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 22487; Mature: 22487

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVDHPIFLESIRFIRSHLLANDLNYLEKKVLERLVHTSGDFSVQNLVNFSDGACEKGLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHH
ALKNGAPILTDTDMAAAAIKNMAENTTRNKVFTARMWFEKNNHTNLTKTAYGLSEGWKEL
HHHCCCCCEECCHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
SAMNSGGKSPIVVIGSSPTALTYLIDILENAKDLPSLIIGMPVGFIGVEKSKNKLISTDL
HHHCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
PRIVLNSTRGGAAMAAATVNALLRETL
CHHEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVDHPIFLESIRFIRSHLLANDLNYLEKKVLERLVHTSGDFSVQNLVNFSDGACEKGLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHH
ALKNGAPILTDTDMAAAAIKNMAENTTRNKVFTARMWFEKNNHTNLTKTAYGLSEGWKEL
HHHCCCCCEECCHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
SAMNSGGKSPIVVIGSSPTALTYLIDILENAKDLPSLIIGMPVGFIGVEKSKNKLISTDL
HHHCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
PRIVLNSTRGGAAMAAATVNALLRETL
CHHEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]