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The map label for this gene is manC [H]

Identifier: 126696771

GI number: 126696771

Start: 1202170

End: 1203618

Strand: Direct

Name: manC [H]

Synonym: P9301_14331

Alternate gene names: 126696771

Gene position: 1202170-1203618 (Clockwise)

Preceding gene: 126696770

Following gene: 126696772

Centisome position: 73.22

GC content: 30.64

Gene sequence:

>1449_bases
ATGCATAAAAAAGATATATTACCCGTAATACTTTGTGGAGGAAGAGGGAGTAGATTATGGCCACTTTCTAGATCAAGTTA
CCCGAAACAGTTTATTTCTTTTTCAAGTCAATCAAGTTTTTCTCTTTTACAAAAAACAATTAAAAGATTATCTAATTTTG
ACAATATTGATAATCCAATATTAATTTGTAATGAGGAGCATAGATTTATAACTGCAGAACAAGTTAAGTCTATAGGTGTA
AAACCTAAATCAATTTTACTAGAACCATTTGGAAAGGGCACGACTGCTGCTATTGCATTAGCTGCTCTGAAGGCTATAGA
GAATAATACTAATCCAAAACTACTAATACTTTCATCAGATCATGAAATTGGTAATTTAAAAAATTTCAAAGAATCCATTA
AAGAAGGCTTGTCTTTTGCTGATGATGGCAGGTTGGTAACATTTGGTATTATGCCAACCTATGCTGAAACAGGATTTGGT
TATATAAAAACTAATGAAAAATTAGAGGCAGGTATTATCAAAGGATATGAAATAAAAAAGTTTGTAGAAAAACCTAATTA
TGAAAAAGCCAAAGAGTTTGTGCGAGATAAACACTACGTATGGAATAGCGGCATATTTCTTTTTAAGGCCACAAAAATTT
TAGAAGAAATAAAGAATCATGCTCCTAATACCTATGAAATATGTGCCAAATCGATAAATGTCAAAAATTTAGACTTAGAT
TTTCAAAGAATTGATAGAAAGATTTTTTCAAATTGTAAAGAAAGCTCAATCGATATTTCCATTATGGAGAAAACCAAACT
TGGAACGATGATTCCAATGGACGCTAATTGGCGCGACATTGGTAGTTGGGACCAAGTTTGGGAGAATTCTACAAAAGATA
AAAATGGAAATTCGAAGAGAGGAAATGTGATTCTAAAAGAAGTAAAAAATAGTCTTTTTATTTCTGAAAATAGACTAGTT
GTTGGTCTAGGTGTAGAGGAATTAATCCTTATTGAAACGAGTGATGCTATTTTGGTACTAAATAAGAGATTTTCACAAAA
AGTTAAAAATATAGTTGAGCAATTTGATAAGACAAAGAATTTAGAAGGCTTCGAGCATAAGAAAATTTATAGACCATGGG
GGAATTATGAATCACTTGTAGAAGATGAAAAATGGAAAGTAAAAAAAATAATCGTAAAGCCAAATCAATCGCTTTCTTTA
CAATCACATAAGCACAGATCGGAACATTGGATAGTAGTGAGAGGTATTGCTAAAGTTGAAATCAGTGAAAATATTTTTTA
TCTGAATGAAAATGAGAGTGCTTATATTCCTAAAAAAGCATTGCACAGGCTATCAAATCCAGGTAATGAAATACTGATAA
TTATAGAAGTTCAGACAGGTTCATATTTGGGAGAAGATGATATTAAAAGAATTGAAGACTATTACGGTAGAGTTACAAAT
AAAGATTAA

Upstream 100 bases:

>100_bases
AAAATATTCAAACCTTGGAAATTGATTAAGAAAATTTAATTTTAAATTAGGTTAATATGCAAAAAACATTTTTAATCGTT
TTTATTATTTCTTTAAATTA

Downstream 100 bases:

>100_bases
TTAATTAATAAATGAGGTATTTGCATCTTAAAAGTTAATTTTGTCTCGAATAGAATATCAAATTTTATACTATAGTAAAT
TTGAATTCTGTTAAAAAGTC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MHKKDILPVILCGGRGSRLWPLSRSSYPKQFISFSSQSSFSLLQKTIKRLSNFDNIDNPILICNEEHRFITAEQVKSIGV
KPKSILLEPFGKGTTAAIALAALKAIENNTNPKLLILSSDHEIGNLKNFKESIKEGLSFADDGRLVTFGIMPTYAETGFG
YIKTNEKLEAGIIKGYEIKKFVEKPNYEKAKEFVRDKHYVWNSGIFLFKATKILEEIKNHAPNTYEICAKSINVKNLDLD
FQRIDRKIFSNCKESSIDISIMEKTKLGTMIPMDANWRDIGSWDQVWENSTKDKNGNSKRGNVILKEVKNSLFISENRLV
VGLGVEELILIETSDAILVLNKRFSQKVKNIVEQFDKTKNLEGFEHKKIYRPWGNYESLVEDEKWKVKKIIVKPNQSLSL
QSHKHRSEHWIVVRGIAKVEISENIFYLNENESAYIPKKALHRLSNPGNEILIIIEVQTGSYLGEDDIKRIEDYYGRVTN
KD

Sequences:

>Translated_482_residues
MHKKDILPVILCGGRGSRLWPLSRSSYPKQFISFSSQSSFSLLQKTIKRLSNFDNIDNPILICNEEHRFITAEQVKSIGV
KPKSILLEPFGKGTTAAIALAALKAIENNTNPKLLILSSDHEIGNLKNFKESIKEGLSFADDGRLVTFGIMPTYAETGFG
YIKTNEKLEAGIIKGYEIKKFVEKPNYEKAKEFVRDKHYVWNSGIFLFKATKILEEIKNHAPNTYEICAKSINVKNLDLD
FQRIDRKIFSNCKESSIDISIMEKTKLGTMIPMDANWRDIGSWDQVWENSTKDKNGNSKRGNVILKEVKNSLFISENRLV
VGLGVEELILIETSDAILVLNKRFSQKVKNIVEQFDKTKNLEGFEHKKIYRPWGNYESLVEDEKWKVKKIIVKPNQSLSL
QSHKHRSEHWIVVRGIAKVEISENIFYLNENESAYIPKKALHRLSNPGNEILIIIEVQTGSYLGEDDIKRIEDYYGRVTN
KD
>Mature_482_residues
MHKKDILPVILCGGRGSRLWPLSRSSYPKQFISFSSQSSFSLLQKTIKRLSNFDNIDNPILICNEEHRFITAEQVKSIGV
KPKSILLEPFGKGTTAAIALAALKAIENNTNPKLLILSSDHEIGNLKNFKESIKEGLSFADDGRLVTFGIMPTYAETGFG
YIKTNEKLEAGIIKGYEIKKFVEKPNYEKAKEFVRDKHYVWNSGIFLFKATKILEEIKNHAPNTYEICAKSINVKNLDLD
FQRIDRKIFSNCKESSIDISIMEKTKLGTMIPMDANWRDIGSWDQVWENSTKDKNGNSKRGNVILKEVKNSLFISENRLV
VGLGVEELILIETSDAILVLNKRFSQKVKNIVEQFDKTKNLEGFEHKKIYRPWGNYESLVEDEKWKVKKIIVKPNQSLSL
QSHKHRSEHWIVVRGIAKVEISENIFYLNENESAYIPKKALHRLSNPGNEILIIIEVQTGSYLGEDDIKRIEDYYGRVTN
KD

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=482, Percent_Identity=44.1908713692946, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 55192; Mature: 55192

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKDILPVILCGGRGSRLWPLSRSSYPKQFISFSSQSSFSLLQKTIKRLSNFDNIDNPI
CCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCE
LICNEEHRFITAEQVKSIGVKPKSILLEPFGKGTTAAIALAALKAIENNTNPKLLILSSD
EEECCCCCEEEHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
HEIGNLKNFKESIKEGLSFADDGRLVTFGIMPTYAETGFGYIKTNEKLEAGIIKGYEIKK
CCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHCCCCEEEEECCCHHHCCCCCHHHHH
FVEKPNYEKAKEFVRDKHYVWNSGIFLFKATKILEEIKNHAPNTYEICAKSINVKNLDLD
HHHCCCHHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCC
FQRIDRKIFSNCKESSIDISIMEKTKLGTMIPMDANWRDIGSWDQVWENSTKDKNGNSKR
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCC
GNVILKEVKNSLFISENRLVVGLGVEELILIETSDAILVLNKRFSQKVKNIVEQFDKTKN
CCCHHHHHHHHEEEECCCEEEEECCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHCC
LEGFEHKKIYRPWGNYESLVEDEKWKVKKIIVKPNQSLSLQSHKHRSEHWIVVRGIAKVE
CCCCCCCEEECCCCCHHHHHCCCCEEEEEEEECCCCCCCCHHCCCCCCCEEEEEEEEEEE
ISENIFYLNENESAYIPKKALHRLSNPGNEILIIIEVQTGSYLGEDDIKRIEDYYGRVTN
EECCEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCC
KD
CC
>Mature Secondary Structure
MHKKDILPVILCGGRGSRLWPLSRSSYPKQFISFSSQSSFSLLQKTIKRLSNFDNIDNPI
CCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCE
LICNEEHRFITAEQVKSIGVKPKSILLEPFGKGTTAAIALAALKAIENNTNPKLLILSSD
EEECCCCCEEEHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
HEIGNLKNFKESIKEGLSFADDGRLVTFGIMPTYAETGFGYIKTNEKLEAGIIKGYEIKK
CCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHCCCCEEEEECCCHHHCCCCCHHHHH
FVEKPNYEKAKEFVRDKHYVWNSGIFLFKATKILEEIKNHAPNTYEICAKSINVKNLDLD
HHHCCCHHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCC
FQRIDRKIFSNCKESSIDISIMEKTKLGTMIPMDANWRDIGSWDQVWENSTKDKNGNSKR
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCC
GNVILKEVKNSLFISENRLVVGLGVEELILIETSDAILVLNKRFSQKVKNIVEQFDKTKN
CCCHHHHHHHHEEEECCCEEEEECCCEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHCC
LEGFEHKKIYRPWGNYESLVEDEKWKVKKIIVKPNQSLSLQSHKHRSEHWIVVRGIAKVE
CCCCCCCEEECCCCCHHHHHCCCCEEEEEEEECCCCCCCCHHCCCCCCCEEEEEEEEEEE
ISENIFYLNENESAYIPKKALHRLSNPGNEILIIIEVQTGSYLGEDDIKRIEDYYGRVTN
EECCEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCC
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]