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The map label for this gene is csd [H]

Identifier: 126695419

GI number: 126695419

Start: 84414

End: 85667

Strand: Reverse

Name: csd [H]

Synonym: P9301_00811

Alternate gene names: 126695419

Gene position: 85667-84414 (Counterclockwise)

Preceding gene: 126695420

Following gene: 126695417

Centisome position: 5.22

GC content: 30.78

Gene sequence:

>1254_bases
ATGGATACAATTCAAAATTTTCCTGAAATAACAAAGAAGGACTTTCCCCTTTTAAATAAGAACTTAAAAAGTAGTGAGCA
AATTATTTATTTAGACCATGCTGCAACTACTCAAAAACCAATTCAAGTTTTAGAAAAAATTAATGAATACTATAGAAACT
TTAATGCCAATGTACATAGAGGTGCACATCAATTAAGTGCTAAAGCGACAGAAGAATTTGAAAATTCAAGATATTTAATT
AGCAAATTTATAAAAGCGAATTCTACAAAAGAAATTATTTTCACAAGAAATGCTACTGAGGCAATCAATCTAGCTGCTAG
ATCATGGGGCGAATCTTCATTAAAAGAAAACGATGAAATTCTCTTATCAATAATGGAACATCATAGCAATATTGTTCCAT
GGCAAATGGTTGCAGCAAAAAATAATTGCAAATTAAAATTTATAGGTATAGATAAAAATGGGAAATTAGATTTAGACGAT
TTTAAATCAAAACTAACATCTAGAACTAAGCTTGTTAGCCTTGTACATATTAGTAATACTCTAGGTTGCTGTAATCCCAT
CAAAGAGATCACTAAATTAGCTAAACAAAAAGGTTCTTTAGTTTTAATAGATGCATGTCAAAGTTTGGCCCATCAAAAAC
TAGATGTTAATGATCTTAATATAGATTTTTTAGCGGGATCAGGACATAAACTTTGCGGTCCTACAGGTATTGGCTTCCTC
TGGTCAAGAAAAGAAATCCTAGAAAAAATTCCTCCTCTCTTTGGAGGTGGCGAAATGATACAAGATGTGTTTGAAGAGAC
AAGTACTTGGGCAGATTTACCACATAAATTTGAAGCTGGAACTCCAGCCATTGCAGAAGCAATAGGTCTTGCAGAAGCAA
TTAACTATATAAACACTATTGGATTGAGTGAAATTCATGAATATGAAAAGAATATTACTAAATATTTATTTGAAAAATTA
AGTGCAATAGAAAATGTTGAAATCATAGGTCCATCACCCGAAATAGATCCAGAAAGAGCATCACTTGCCACTTTTTATGT
AAAAAATATACATTCAAACGATATTGCCGAAATTCTTGATTCAAAAGGAATTTGCATCAGAAGCGGTCACCATTGCTGTC
AACCTCTTCATAGATACATTGGAATTAAATCGACAGCTAGAATCAGCATGAATTTTACAACAAATAAGGAAGAAATTGAT
ATGTTTATAGAAAAATTAAAAGATACTATTGATTTTCTAAAAATCAATTCTTAA

Upstream 100 bases:

>100_bases
GTAAACTACAATTAACTTCTTACTTTCAAGAAATAATTTCATTTATTCCCGTTTCAAAAGATAGATGGGATTTGCTTGAT
AAACTTTTAAATGAAAATTA

Downstream 100 bases:

>100_bases
ATATTCAAAGCATTTCTTAAAAATTCCTGAGATTTTTGCATTACTACTTCTTTATTTTCAATATTTCTAAACCCATGCCC
TTCATTATCAAAAAAAATAA

Product: putative cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDTIQNFPEITKKDFPLLNKNLKSSEQIIYLDHAATTQKPIQVLEKINEYYRNFNANVHRGAHQLSAKATEEFENSRYLI
SKFIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNNCKLKFIGIDKNGKLDLDD
FKSKLTSRTKLVSLVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVNDLNIDFLAGSGHKLCGPTGIGFL
WSRKEILEKIPPLFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLSEIHEYEKNITKYLFEKL
SAIENVEIIGPSPEIDPERASLATFYVKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
MFIEKLKDTIDFLKINS

Sequences:

>Translated_417_residues
MDTIQNFPEITKKDFPLLNKNLKSSEQIIYLDHAATTQKPIQVLEKINEYYRNFNANVHRGAHQLSAKATEEFENSRYLI
SKFIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNNCKLKFIGIDKNGKLDLDD
FKSKLTSRTKLVSLVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVNDLNIDFLAGSGHKLCGPTGIGFL
WSRKEILEKIPPLFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLSEIHEYEKNITKYLFEKL
SAIENVEIIGPSPEIDPERASLATFYVKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
MFIEKLKDTIDFLKINS
>Mature_417_residues
MDTIQNFPEITKKDFPLLNKNLKSSEQIIYLDHAATTQKPIQVLEKINEYYRNFNANVHRGAHQLSAKATEEFENSRYLI
SKFIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNNCKLKFIGIDKNGKLDLDD
FKSKLTSRTKLVSLVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVNDLNIDFLAGSGHKLCGPTGIGFL
WSRKEILEKIPPLFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLSEIHEYEKNITKYLFEKL
SAIENVEIIGPSPEIDPERASLATFYVKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
MFIEKLKDTIDFLKINS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=24.9376558603491, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI156713448, Length=329, Percent_Identity=26.1398176291793, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787970, Length=398, Percent_Identity=40.9547738693467, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=31.2807881773399, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=25.9351620947631, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25143064, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193211090, Length=399, Percent_Identity=25.062656641604, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=26.3959390862944, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129463, Length=284, Percent_Identity=29.5774647887324, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46904; Mature: 46904

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIQNFPEITKKDFPLLNKNLKSSEQIIYLDHAATTQKPIQVLEKINEYYRNFNANVHR
CCCHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENSRYLISKFIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEI
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHCCCHHH
LLSIMEHHSNIVPWQMVAAKNNCKLKFIGIDKNGKLDLDDFKSKLTSRTKLVSLVHISNT
HHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCH
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVNDLNIDFLAGSGHKLCGPTGIGFL
HHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHH
WSRKEILEKIPPLFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLSEIHEYEKNITKYLFEKLSAIENVEIIGPSPEIDPERASLATFYVKNIHSNDIAEILD
CHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDMFIEKLKDTIDFLKINS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MDTIQNFPEITKKDFPLLNKNLKSSEQIIYLDHAATTQKPIQVLEKINEYYRNFNANVHR
CCCHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENSRYLISKFIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEI
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHCCCHHH
LLSIMEHHSNIVPWQMVAAKNNCKLKFIGIDKNGKLDLDDFKSKLTSRTKLVSLVHISNT
HHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCH
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVNDLNIDFLAGSGHKLCGPTGIGFL
HHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHH
WSRKEILEKIPPLFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLSEIHEYEKNITKYLFEKLSAIENVEIIGPSPEIDPERASLATFYVKNIHSNDIAEILD
CHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDMFIEKLKDTIDFLKINS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]