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The map label for this gene is pncB [H]

Identifier: 126701167

GI number: 126701167

Start: 4137954

End: 4139384

Strand: Direct

Name: pncB [H]

Synonym: CD3543

Alternate gene names: 126701167

Gene position: 4137954-4139384 (Clockwise)

Preceding gene: 126701142

Following gene: 126701168

Centisome position: 96.45

GC content: 31.45

Gene sequence:

>1431_bases
ATGAGAAATCTAACACTTCTTACTGATTTATATCAGCTTACTATGTTAAATGGCTATTTTGAAAAGAATATTCATGAAGA
CATTGTTGTATTTGATATGTTTTTTAGAAAAAACGCTTGTGATGGAGGGTATACTATAGTTTGTGGTATTGATCAGGTTG
TTGAATACATAGATAATCTTCATTTTTCAGATGAAGATTTAGAGTACTTAAAAAACTTAAATTTATTTTCTGACAAGTTC
TTAAAATTTTTAAAAGAATTTAAATTCACAGGAGATATATATGCTGTTGAGGAAGGAACTATCATGTTCCCTAATGAGCC
ATTAATTACTGTTAAGGCACCTTTATATCAAGCTCAACTTATTGAAACAGCATTGTTAACAATAGTTAATTTTCAGTCTC
TTATTGCTACTAAAGCATCTAGAGTTTGCTTTGCAGCTCAAGGAGACCCTGTATTTGAATTTGGATTACGTCGTGCACAA
GGTCCAGATGCAGGGATATATGGAGCTAGGGCTGCCGTAGTTGGTGGTTGTGCTGGAACTGCAAACGTACTAGCAGGGAA
AATGTTTGATATACCTATAATTGGTACACAAGCTCACAGTTGGGTTCAAAAATTTGATAATGAACTTGAAGCATTCCAAG
CATATGCTGATGTTTATCCAGATAAATGCCTACTACTTGTAGATACTTATGATGTATTAAATAGTGGAGTTCCTAATGCA
ATAAAAGTATTCAAAAATATTTCTGAAAAAGGATACAAACCTATGGGTATAAGACTTGACTCTGGAGATTTAGCTTATTT
ATCTAAAGAAGCTAAAAAACAATTAGATAATGCTGGCTTTTCAGATATCAGCATCACTGCATCTAATGACCTAGACGAAT
ATACCATAACATCACTTAAAGCAGAAGGAGCTACTATAAATTCATGGGGAGTAGGTACAAAGCTCATTACATCTTTCGAT
TCACCTTCTCTTGGAGGAGTTTATAAATTAGCTGCATCTTGTGAAAAAGGAGTTCTTGAACCTAAGATAAAGATTTCTGA
GAATCCAGAAAAAATAAATAATCCTGGTTACAAGAAAGTTATAAGAATATATAACGAAGACAATAAGGCAGAGGCAGATT
TGATTATGTTACATGATGAAGTTATAGATGAGTCTAAACCTTTAGAAATCTTCCATCCTACTTATACATGGAAAACGAAG
GTATTTACAAATTACAAAGTTAAAGAGCTTCTTAAACCATTGTATATAAAAGGCAGATGCAAATATAATAAAAAAGCTGT
TCTTGAAATAAAAAATCATGTACAATATGAATTAAGTACTATCTGGGAACAATACAAAAGACTTTCAAAACCACACATTT
ATAAGGTTGATTTATCTAGAAATCTTTGGTATTTAAAAACACAAATGATAGATTCTAAAAAAGTTTTATAG

Upstream 100 bases:

>100_bases
GTAATACTTTATACTTGAAAGTTGTACTATATTATGTTTTAGTATAAGTGTGGGAGTTTTTACAATTTTTAATATTTAAT
AATAATTAAGGAGAGAAATA

Downstream 100 bases:

>100_bases
CATTAATTATTTTTATTTAAGGGGGACTGTTTATTTATGGATGTTACAGATTACAGAATCATAGAAATTTTACAGGATGA
TGGGAGAATTTCTATGAAGG

Product: nicotinate phosphribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGYTIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKF
LKFLKEFKFTGDIYAVEEGTIMFPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADVYPDKCLLLVDTYDVLNSGVPNA
IKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLDNAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFD
SPSLGGVYKLAASCEKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFHPTYTWKTK
VFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSKPHIYKVDLSRNLWYLKTQMIDSKKVL

Sequences:

>Translated_476_residues
MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGYTIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKF
LKFLKEFKFTGDIYAVEEGTIMFPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADVYPDKCLLLVDTYDVLNSGVPNA
IKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLDNAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFD
SPSLGGVYKLAASCEKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFHPTYTWKTK
VFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSKPHIYKVDLSRNLWYLKTQMIDSKKVL
>Mature_476_residues
MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGYTIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKF
LKFLKEFKFTGDIYAVEEGTIMFPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADVYPDKCLLLVDTYDVLNSGVPNA
IKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLDNAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFD
SPSLGGVYKLAASCEKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFHPTYTWKTK
VFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSKPHIYKVDLSRNLWYLKTQMIDSKKVL

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=519, Percent_Identity=31.5992292870906, Blast_Score=262, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71997947, Length=522, Percent_Identity=36.7816091954023, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71997952, Length=522, Percent_Identity=36.7816091954023, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=41.1483253588517, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=35.4527938342967, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI161076680, Length=276, Percent_Identity=37.3188405797101, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24581595, Length=276, Percent_Identity=37.3188405797101, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI28574709, Length=276, Percent_Identity=37.3188405797101, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24581593, Length=276, Percent_Identity=37.3188405797101, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24581591, Length=276, Percent_Identity=37.3188405797101, Blast_Score=175, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 53822; Mature: 53822

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGYTIVCGIDQVVEYIDNL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHCCCCCCCEEEEECHHHHHHHHHCC
HFSDEDLEYLKNLNLFSDKFLKFLKEFKFTGDIYAVEEGTIMFPNEPLITVKAPLYQAQL
CCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEEEECCHHHHHH
IETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQGPDAGIYGARAAVVGGCAGT
HHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHEECCCCH
ANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADVYPDKCLLLVDTYDVLNSGVPNA
HHHHHCCEECCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCHH
IKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLDNAGFSDISITASNDLDEYTITSLK
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEE
AEGATINSWGVGTKLITSFDSPSLGGVYKLAASCEKGVLEPKIKISENPEKINNPGYKKV
CCCCEEECCCCCHHHEECCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCHHCCCCCHHHH
IRIYNEDNKAEADLIMLHDEVIDESKPLEIFHPTYTWKTKVFTNYKVKELLKPLYIKGRC
EEEECCCCCCCCCEEEEEHHHCCCCCCEEEECCCEEEEEEEEECCCHHHHHHHHEEECCC
KYNKKAVLEIKNHVQYELSTIWEQYKRLSKPHIYKVDLSRNLWYLKTQMIDSKKVL
CCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGYTIVCGIDQVVEYIDNL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHCCCCCCCEEEEECHHHHHHHHHCC
HFSDEDLEYLKNLNLFSDKFLKFLKEFKFTGDIYAVEEGTIMFPNEPLITVKAPLYQAQL
CCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEEEECCHHHHHH
IETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQGPDAGIYGARAAVVGGCAGT
HHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHEECCCCH
ANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADVYPDKCLLLVDTYDVLNSGVPNA
HHHHHCCEECCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCHH
IKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLDNAGFSDISITASNDLDEYTITSLK
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEE
AEGATINSWGVGTKLITSFDSPSLGGVYKLAASCEKGVLEPKIKISENPEKINNPGYKKV
CCCCEEECCCCCHHHEECCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCHHCCCCCHHHH
IRIYNEDNKAEADLIMLHDEVIDESKPLEIFHPTYTWKTKVFTNYKVKELLKPLYIKGRC
EEEECCCCCCCCCEEEEEHHHCCCCCCEEEECCCEEEEEEEEECCCHHHHHHHHEEECCC
KYNKKAVLEIKNHVQYELSTIWEQYKRLSKPHIYKVDLSRNLWYLKTQMIDSKKVL
CCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]