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The map label for this gene is fruA [H]

Identifier: 126700187

GI number: 126700187

Start: 2969540

End: 2970646

Strand: Direct

Name: fruA [H]

Synonym: CD2568

Alternate gene names: 126700187

Gene position: 2969540-2970646 (Clockwise)

Preceding gene: 126700186

Following gene: 126700188

Centisome position: 69.22

GC content: 34.15

Gene sequence:

>1107_bases
ATGAGTAAAAAAAATAAATCTCTTTTAAGTGAACTTAAGGGACACTTAATGACAGGTATCTCATATATGTTGCCACTTGT
AATAGGCTCATCTTTAGTTGTAGCTATCCCAAAGCTTACAGCTTTAGCAATGGGTATAACAAGTTTAGATGCTTATAAAA
ATGTATCTGGTTTTTATCATATTCTTTACTTAATGGAACAAGTTGGTTGGACTGGCATAGGTCTATTAAATACGGTATTA
GCAGGATTTATAGCATTTTCAATAGGTGAGAAACCAGCTATGGGTGCAGGTTTTATTGGTGGGCTCATAGCAAGTAATAC
TAATGCAGGATTCTTAGGAGCAGTAATAGCAGGTTTCTTTGCTGGGTATGTTTGTAAGTTTTTAAAGAAAAAAATTAAAA
TATCTGGGTCAGCATCAGGAATGATGCCACTTATAATAATGCCACTTATAACAGTTGGATTAACTGGTTTTTTAATGAGT
GTTGTATTAGCAGGACCTTTAGGAAACATAAATACTTCATTAAATGCTTGGGTAGCTGAAATGTGTCAAAATGGAACAAA
TTCGGTGGTATTGGCTTTAATTTTAGGCGCAATGATAGGATTCGATTTAGGTGGACCAGTAAATAAAGCAGCTTGGATGG
CAGGAAATGCATTATTGTTAGAGGGAATCTATCTACCAGCGATATTGGTAAACTGCGCAATAGTTATACCTCCACTAGGA
TATGGTTTAGCTACATTCATAAGAAAATCAAAATTTTCCAATGCATTAGCTGAAACAGGAAAAGGCAATATAGTTATGGG
CATAATTGGAATAACAGAAGGTGCAATTCCTTTCACTTTAACAAATCCATTAAAATTAGTTCCTGTTAATATGATAGGAT
GCGCTTTGGGTGTAGGATTATCAGCTTTGTTAGGTGTACATGCTATAATGCCTCCAGTTGGTGGATTATATGGATTTATA
TCAATAGGTTCTGGATGGGCTTACTTAGTAGGTGCAATATTTGGAGCTTTAGTAATAGCAATATTATCAACAACTTTAGT
AGACTTCAATGAAGATGAAACTACGGAAAATACAGAATTTGATGAAATAGAGTTAGATATAATGTAA

Upstream 100 bases:

>100_bases
CTCTAATATAGAATGAGAAAAATCAAAAATTAAAAAATTGTCTAATGTAATTATAACATATTATCAAAAAATATAACAAA
CTTATATAGGAGGATTAAAA

Downstream 100 bases:

>100_bases
ATTAAAAACTTAATTTTAGATAATTGAGAATTGAGTGTACTCTCAATTCTCAATTAAATTTTGGGAGGATTTTTATGAAA
AAGACAAAAGTACATGTAGT

Product: PTS system transporter subunit IIC

Products: NA

Alternate protein names: EIIBBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAMGITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVL
AGFIAFSIGEKPAMGAGFIGGLIASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMS
VVLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNALLLEGIYLPAILVNCAIVIPPLG
YGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAIPFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFI
SIGSGWAYLVGAIFGALVIAILSTTLVDFNEDETTENTEFDEIELDIM

Sequences:

>Translated_368_residues
MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAMGITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVL
AGFIAFSIGEKPAMGAGFIGGLIASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMS
VVLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNALLLEGIYLPAILVNCAIVIPPLG
YGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAIPFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFI
SIGSGWAYLVGAIFGALVIAILSTTLVDFNEDETTENTEFDEIELDIM
>Mature_367_residues
SKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAMGITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVLA
GFIAFSIGEKPAMGAGFIGGLIASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMSV
VLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNALLLEGIYLPAILVNCAIVIPPLGY
GLATFIRKSKFSNALAETGKGNIVMGIIGITEGAIPFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFIS
IGSGWAYLVGAIFGALVIAILSTTLVDFNEDETTENTEFDEIELDIM

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=327, Percent_Identity=38.5321100917431, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790386, Length=322, Percent_Identity=35.0931677018634, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1786951, Length=282, Percent_Identity=34.3971631205674, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87082348, Length=333, Percent_Identity=30.03003003003, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788729, Length=374, Percent_Identity=28.3422459893048, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 38201; Mature: 38070

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAMGITSLDAYKNVSGFYH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILYLMEQVGWTGIGLLNTVLAGFIAFSIGEKPAMGAGFIGGLIASNTNAGFLGAVIAGFF
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
AGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMSVVLAGPLGNINTSLNAWVAE
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNALLLEGIYLPAILVNCAIVIPPLG
HHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
YGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAIPFTLTNPLKLVPVNMIGCALGVGL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHH
SALLGVHAIMPPVGGLYGFISIGSGWAYLVGAIFGALVIAILSTTLVDFNEDETTENTEF
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEIELDIM
CCEEEEEC
>Mature Secondary Structure 
SKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAMGITSLDAYKNVSGFYH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILYLMEQVGWTGIGLLNTVLAGFIAFSIGEKPAMGAGFIGGLIASNTNAGFLGAVIAGFF
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
AGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMSVVLAGPLGNINTSLNAWVAE
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNALLLEGIYLPAILVNCAIVIPPLG
HHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
YGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAIPFTLTNPLKLVPVNMIGCALGVGL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHH
SALLGVHAIMPPVGGLYGFISIGSGWAYLVGAIFGALVIAILSTTLVDFNEDETTENTEF
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEIELDIM
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2254279 [H]