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The map label for this gene is hisC [H]

Identifier: 126700118

GI number: 126700118

Start: 2887567

End: 2888670

Strand: Direct

Name: hisC [H]

Synonym: CD2502

Alternate gene names: 126700118

Gene position: 2887567-2888670 (Clockwise)

Preceding gene: 126700114

Following gene: 126700121

Centisome position: 67.31

GC content: 27.81

Gene sequence:

>1104_bases
ATGAAACTAAAAATTAACAAAGCTATTGAAATGCAGTTGAAAAAAAGTTATGCAATAGAATCTGGACATTCAGAAGATGT
ATTCGAGATAGACTGTGGTGAAGGTATAAATACCGTGTCTTACTCAAACAAAGCTGTAGAAGCTTTTAATGCTTTAAAAT
TTGATATGATAAGAGGATATCCTCATTCAATTGCTTTAAAAGATAATATAGTCGATTATTGGAAAGATTTTATAGCATTA
GATACTGACAGAATTTGTTTGGCAGATGGTTCTATACATGTTATTTACCTTTTAAATAGACTATTTATTGAAAAGGGAGA
TAAAGTTTTAGGATATTCACCTCAGTTCTCAGAATATGAGACAGATATAAAAATGCATGGTGCAACTTATGATTATGTTC
TTTTAAAGAAAGAGGATAATTTCAAGTTTAATGAAAAAGAATTTATTGAAAAAATAAATCCAGAATATAAAGTAATTTAC
ATAGACAATCCAAACAATCCTACAGGACAAATTATACCTTTATCATCAATTGAAAATATAGTAAGGGAAGCAGCTAAATA
TGATATAGCAGTTATGGTAGATGAAGCTTATGGTGAATACATGCCAAAAGAAAATTCAGCTGTCAAGCTTCTAAATAATT
ATGATAATGTAATTGCTTTAAAAACATTTTCAAAAGGATTTGGTTTAGCAGGACTAAGAGCAGGATATGCAGTTCTTCCA
GAACAACTTGTTAGCCCTATTAAAAAGATTTCTACTCCTTACGAAGTGTCTGAAATATCTCGTAGTATTGCAGCAAATTT
ATTAGATGATGTTCAATTTATAGAAGAATTAAAAGAAAAAACAAAAGATATAAAAAATCAATTATTAATTCCATGGAAAA
ACCTTAATATAGCTGAAACTAGTGATACTGTATCAATTATGACAGTTGAACATAAAAACAAGGACATAGATTTACAACAA
GAGTTTGCTAAATTAAAAATAAGAGTTATATCTGGAAGTGATTTTACTGGACTTGATAAAAATTTTATAAGATTTAGAAT
GCCTGAAGAAAAAGAATTACCTGAAGTTATAAAAGCATTCCAAATAATCGATAATATAGAATAA

Upstream 100 bases:

>100_bases
TAATATTTATATTCATTTTTACTATTATATATTTTCATAATATTTTAAATCTAGCAACTTTTATAACATTTATTATTGAC
TAAATAAGGAGTGATAAAGT

Downstream 100 bases:

>100_bases
ATTAGACTATTTATAAAAGGCATATTGTTAAAATCAATATGCCCTTTAATTTTTTGATTATTTTACTTCACTTCTATTTA
TTAATTTGTTAAGTTCCATT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNKAVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIAL
DTDRICLADGSIHVIYLLNRLFIEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
IDNPNNPTGQIIPLSSIENIVREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVIALKTFSKGFGLAGLRAGYAVLP
EQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEELKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQ
EFAKLKIRVISGSDFTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE

Sequences:

>Translated_367_residues
MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNKAVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIAL
DTDRICLADGSIHVIYLLNRLFIEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
IDNPNNPTGQIIPLSSIENIVREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVIALKTFSKGFGLAGLRAGYAVLP
EQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEELKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQ
EFAKLKIRVISGSDFTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE
>Mature_367_residues
MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNKAVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIAL
DTDRICLADGSIHVIYLLNRLFIEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
IDNPNNPTGQIIPLSSIENIVREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVIALKTFSKGFGLAGLRAGYAVLP
EQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEELKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQ
EFAKLKIRVISGSDFTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=216, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788722, Length=247, Percent_Identity=27.5303643724696, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786816, Length=173, Percent_Identity=20.8092485549133, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=202, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994472, Length=220, Percent_Identity=26.8181818181818, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994476, Length=220, Percent_Identity=26.8181818181818, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=224, Percent_Identity=26.7857142857143, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573069, Length=240, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646114, Length=240, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573067, Length=240, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573065, Length=240, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41957; Mature: 41957

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNKAVEAFNALKFDMIRGY
CEEEECHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHCCC
PHSIALKDNIVDYWKDFIALDTDRICLADGSIHVIYLLNRLFIEKGDKVLGYSPQFSEYE
CCEEEEEHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHCCCEEECCCCCCCCCC
TDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIYIDNPNNPTGQIIPLSSIENI
CCEEECCCEEEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHH
VREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVIALKTFSKGFGLAGLRAGYAVLP
HHHHHHCCEEEEEECHHHCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCHHHCCHHHHH
EQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEELKEKTKDIKNQLLIPWKNLNIAET
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEECC
SDTVSIMTVEHKNKDIDLQQEFAKLKIRVISGSDFTGLDKNFIRFRMPEEKELPEVIKAF
CCEEEEEEEECCCCCCCHHHHHCEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHH
QIIDNIE
HHHHCCC
>Mature Secondary Structure
MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNKAVEAFNALKFDMIRGY
CEEEECHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHCCC
PHSIALKDNIVDYWKDFIALDTDRICLADGSIHVIYLLNRLFIEKGDKVLGYSPQFSEYE
CCEEEEEHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHCCCEEECCCCCCCCCC
TDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIYIDNPNNPTGQIIPLSSIENI
CCEEECCCEEEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHH
VREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVIALKTFSKGFGLAGLRAGYAVLP
HHHHHHCCEEEEEECHHHCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCHHHCCHHHHH
EQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEELKEKTKDIKNQLLIPWKNLNIAET
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEECC
SDTVSIMTVEHKNKDIDLQQEFAKLKIRVISGSDFTGLDKNFIRFRMPEEKELPEVIKAF
CCEEEEEEEECCCCCCCHHHHHCEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHH
QIIDNIE
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA