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The map label for this gene is guaB [H]

Identifier: 126699953

GI number: 126699953

Start: 2700697

End: 2702196

Strand: Direct

Name: guaB [H]

Synonym: CD2335

Alternate gene names: 126699953

Gene position: 2700697-2702196 (Clockwise)

Preceding gene: 126699935

Following gene: 126699963

Centisome position: 62.95

GC content: 34.2

Gene sequence:

>1500_bases
ATGGCGTTTTATTTTGATACACCATCACATACTTTCAGTGAATACCTTCTTGTACCAGGTTTCTCTTCTACTGATTGTAT
ACCTGCTAATGTAAGTTTAAAAACACCTGTTACTAAATTTAAAAAGGGCGAGGAAGCAGATATTTATATGAATATACCTT
TGACTTCTGCTATTATGCAATCTGTTTCTGATGACAAAATGGCTATTGCACTTGCTAAAGAAGGTGGTATTTCATTTATA
TACGGTTCTCAAACTATTGAAAATGAAGCTGCTATGGTAGCACGTGTTAAATCCCACAAAGCTGGTTTTGTTGTAAGTGA
TTCAAATATTAAACCTGATAACACATTAAAAGACATACTTGACTTAAAAGAAAAAACTGGACATTCTACAGTAGCTGTTA
CTGAAGATGGAACTTCAACTGGTAAATTATTGGGTATTGTTGCAAGTCGTGATTATCGTATAAGTCGTATGGATTTAGAT
ACTAAAGTTAGTGAATTTATGACTCCTATGTCATCTATAGTTTATGCTAACAAAGATGTTACTTTAAAGGAAGCAAACAA
TATTATATGGGACCACAAACTTAATTCTCTTCCTGTACTTGATGATAATGGTAATCTTATGTATATGGTATTCCGTAAAG
ATTACTCTTCTCATAAAGAAAATCCACTTGAACTTTTAGATTCTTCTAAGAGATATGTAGTTGGAGCTGGTATTAATACT
AGAGACTTTGCTGAACGTGTTCCTGCTTTAGTTGAAGCTGGTGCTGATGTTTTATGTATAGATTCTTCAGAAGGTTTTTC
TGAGTGGCAAAAAATAACACTTGATTTCATTCGTGAAAAATATGGTGATACAGTTAAGGTAGGAGCTGGAAATGTAGTTG
ACCGCGAAGGATTCCTTTACCTAGCTGAAGCTGGTGCTGACTTCGTTAAAGTTGGTATTGGTGGTGGTTCTATATGTATA
ACTCGTGAACAAAAAGGTATAGGACGTGGACAAGCTACTTCTATAATTGAAGTTGCTCAAGCTAGAGACGAATACTTTGA
AAAAACAGGTATTTATATTCCAATTTGCTCTGATGGTGGTATCGTTTATGACCATCATATAACTTTAGCTTTAGCTATGG
GTGCAGATTTTATAATGCTTGGTAGATACTTCTCTCGTTTTGATGAGAGTCCAACTAACAAAGTTAATATAAATGGTAGT
TATATGAAAGAGTATTGGGGAGAAGGTTCTGCTCGTGCTAGAAACTGGCAAAGATATGACCTTGGTGGAGATAAGAAACT
TTCTTTTGAAGAAGGTGTTGACTCTTATGTGCCTTATGCTGGTTCTTTGAAAGACAATGTAACTCTTTCTTTAAGTAAAG
TTCGTTCTACTATGTGTAACTGTGGAGCACTTAGCATTCCTGAACTTCAAAAAAATGCTAAACTTACACTTGTATCTTCT
ACTAGTATAGTTGAAGGTGGAGCTCATGATGTTATGTTAAAAGATAATAGAAATTTATAA

Upstream 100 bases:

>100_bases
ATCTCAATATTTGACAAAATACTTTAATAAAATTAAAGAATAAGTTATAATTAATACTATCAATTATAAAAAGTATAAAA
ATATAAGGAGTGATTAAAAA

Downstream 100 bases:

>100_bases
TATAAATATACTTTAATCATTTAAACAATGAAAAAGAGACTTATCTCTATTTTGAGACAGTCTCTTTTTATATTAGTATA
ATTTTTATTTAACTGTAAAT

Product: inosine 5-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGEEADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFI
YGSQTIENEAAMVARVKSHKAGFVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLD
TKVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSHKENPLELLDSSKRYVVGAGINT
RDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDFIREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICI
TREQKGIGRGQATSIIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPTNKVNINGS
YMKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLSLSKVRSTMCNCGALSIPELQKNAKLTLVSS
TSIVEGGAHDVMLKDNRNL

Sequences:

>Translated_499_residues
MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGEEADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFI
YGSQTIENEAAMVARVKSHKAGFVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLD
TKVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSHKENPLELLDSSKRYVVGAGINT
RDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDFIREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICI
TREQKGIGRGQATSIIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPTNKVNINGS
YMKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLSLSKVRSTMCNCGALSIPELQKNAKLTLVSS
TSIVEGGAHDVMLKDNRNL
>Mature_498_residues
AFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGEEADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFIY
GSQTIENEAAMVARVKSHKAGFVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLDT
KVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSHKENPLELLDSSKRYVVGAGINTR
DFAERVPALVEAGADVLCIDSSEGFSEWQKITLDFIREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICIT
REQKGIGRGQATSIIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPTNKVNINGSY
MKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLSLSKVRSTMCNCGALSIPELQKNAKLTLVSST
SIVEGGAHDVMLKDNRNL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI156616279, Length=499, Percent_Identity=34.6693386773547, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI217035146, Length=499, Percent_Identity=34.6693386773547, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI34328930, Length=499, Percent_Identity=34.6693386773547, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI34328928, Length=499, Percent_Identity=34.6693386773547, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI217035152, Length=497, Percent_Identity=34.8088531187123, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI217035148, Length=499, Percent_Identity=34.0681362725451, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI66933016, Length=499, Percent_Identity=32.064128256513, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI217035150, Length=499, Percent_Identity=32.6653306613226, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI156104880, Length=237, Percent_Identity=32.9113924050633, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI50541956, Length=273, Percent_Identity=30.03663003663, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI50541954, Length=273, Percent_Identity=30.03663003663, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI50541952, Length=273, Percent_Identity=30.03663003663, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI50541948, Length=273, Percent_Identity=30.03663003663, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1788855, Length=494, Percent_Identity=36.0323886639676, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1786293, Length=253, Percent_Identity=32.0158102766798, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994385, Length=510, Percent_Identity=32.5490196078431, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=34.8235294117647, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17560440, Length=257, Percent_Identity=30.3501945525292, Blast_Score=105, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323585, Length=506, Percent_Identity=34.3873517786561, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6323464, Length=504, Percent_Identity=34.1269841269841, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322012, Length=504, Percent_Identity=32.9365079365079, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319352, Length=381, Percent_Identity=34.3832020997375, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24641071, Length=501, Percent_Identity=32.5349301397206, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24641073, Length=501, Percent_Identity=32.5349301397206, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28571163, Length=453, Percent_Identity=33.112582781457, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54778; Mature: 54646

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGEEADIYMNIPLTSAIMQ
CEEEECCCCCCCCCEEEECCCCCCCCEECCEEECCCHHHHCCCCCCEEEEECCHHHHHHH
SVSDDKMAIALAKEGGISFIYGSQTIENEAAMVARVKSHKAGFVVSDSNIKPDNTLKDIL
HCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
DLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLDTKVSEFMTPMSSIVYANKDV
HHHHHCCCCEEEEECCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHCHHHHHEECCCCE
TLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSHKENPLELLDSSKRYVVGAGINT
EEECCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHHHCCCCCEEEECCCCH
RDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDFIREKYGDTVKVGAGNVVDREGFLY
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCEEE
LAEAGADFVKVGIGGGSICITREQKGIGRGQATSIIEVAQARDEYFEKTGIYIPICSDGG
EEECCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
IVYDHHITLALAMGADFIMLGRYFSRFDESPTNKVNINGSYMKEYWGEGSARARNWQRYD
EEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCCCCCCCCCCEEEC
LGGDKKLSFEEGVDSYVPYAGSLKDNVTLSLSKVRSTMCNCGALSIPELQKNAKLTLVSS
CCCCCCCCHHHCCHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHCCCCEEEEEEC
TSIVEGGAHDVMLKDNRNL
CCEECCCCCEEEEECCCCC
>Mature Secondary Structure 
AFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGEEADIYMNIPLTSAIMQ
EEEECCCCCCCCCEEEECCCCCCCCEECCEEECCCHHHHCCCCCCEEEEECCHHHHHHH
SVSDDKMAIALAKEGGISFIYGSQTIENEAAMVARVKSHKAGFVVSDSNIKPDNTLKDIL
HCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
DLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLDTKVSEFMTPMSSIVYANKDV
HHHHHCCCCEEEEECCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHCHHHHHEECCCCE
TLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSHKENPLELLDSSKRYVVGAGINT
EEECCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHHHCCCCCEEEECCCCH
RDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDFIREKYGDTVKVGAGNVVDREGFLY
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCEEE
LAEAGADFVKVGIGGGSICITREQKGIGRGQATSIIEVAQARDEYFEKTGIYIPICSDGG
EEECCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
IVYDHHITLALAMGADFIMLGRYFSRFDESPTNKVNINGSYMKEYWGEGSARARNWQRYD
EEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCCCCCCCCCCEEEC
LGGDKKLSFEEGVDSYVPYAGSLKDNVTLSLSKVRSTMCNCGALSIPELQKNAKLTLVSS
CCCCCCCCHHHCCHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHCCCCEEEEEEC
TSIVEGGAHDVMLKDNRNL
CCEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]