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The map label for this gene is mtrB [H]

Identifier: 126699935

GI number: 126699935

Start: 2678566

End: 2680143

Strand: Direct

Name: mtrB [H]

Synonym: CD2317

Alternate gene names: 126699935

Gene position: 2678566-2680143 (Clockwise)

Preceding gene: 126699934

Following gene: 126699953

Centisome position: 62.43

GC content: 23.0

Gene sequence:

>1578_bases
TTGAAAAACTTAATTATTAATGATTCTAAAGCAAAATTTATTTTATTATTATTACTGTTTCTATTAGTTTCTATATTATT
TGAAGCAGTTTATGATTTGAATAATAACTTTTCTAATATTAATTATTATTATAGAGAGTTTGCTCTCCCTTATTTTTATT
TTTTCGGTACTCCTGTACATTTGTCAAAAGTAGAATTAGAGTTTGTCTGCATAGGTATTATATTATCAAGTTTTTTATTG
ACTATACTATGTTTTACATTGTATAAAAAAAATAAACAAACTAAAGTCAAATTCTTAGAGAATGTCATAAGCCTTTTTTC
TAAGGTAAAAATAGAACTTACACTTATATTAACTTTGATACTATTAACCTTAAGGTTTCATGCATTTACAAGTAATAAAA
TATTTTACAACACTAATTTAATAATCTACAATTTTATAATTATATCTATAGTCTATATAATATATGAAAATATTAAATAT
AATAACTATAATCTAAAAGATATGTCTATAACATATGTATTCTTTTCAAACTTACTTAGTATGTATAATAAAAAAACTAT
AAATAAAAAATTAGCTATAGTATTTTTAATATCTATAGTTGTACAAGCTATTATCCAATATCTTGTTTTGATATTCTTTA
TGTATATATATTATGCTGAGGCAATAGCTATAGTAATTTTATTTACACTTGTAAACACAGTTTTTCATTTTTATATATAC
AACTTTTTATCTGTTAAGTTTAATTACATAAATAACATATCAAAAAATATAAAAAATATAGAAAATGGCAATTTAAAGTA
TAAATTAGAAGTTATAGGAGATGATGAAATATCTACTTTAGCCAAAAGTATAAATAATATAACAGGCGGTCTTGAAACTG
CTGTAGATGCTAATATAAAAAATGAAAGGATGAAGGCAGAGCTTATCACAAACGTATCTCATGACTTAAAAACTCCACTT
ACATCTATATTAAGCTATGTTGATATGTTAAAAAATAATGACTTTGACAGAGAGACTATAAATGACTATATAAATATTTT
AGATAAAAAATCACAAAGATTAAAATTATTAATAGATGACATATTTGAAGCATCTAAGCTAAGTAGTGGAGATGTAGAAT
TTAATATAACAAAAACCGATATAAGAGAACTTTTAATTCAAAGTATTGTAGAGTTTGAAGACAAAATTCAAAATAGCAGT
TTAGATTTTATAATAGAAACACCTGAATATGCTGTTTTTACCATGATAGATGGTAAAAAAACTTGGAGAGTTTTTGAGAA
TCTAATTTGCAATATACTAAAATACTCTATGCCTAACACTAGGGTCTACATAGATATGTTTATAAAGGAAGAAAATATAA
TATTAACGTTTAAAAATATTTCAAATGATAAACTAAATCTAAAGCCAGAAGAGTTAATAGAAAGATTTAGAAGGGGTGAT
ATATCTAGAAAAACAGATGGCTCTGGTCTTGGTTTATCAATTGCTCAAAATATAATTGAATTAGAAAATGCACACATGGA
AATAATTATAGATGCTGATTTATTTAAGGTAATGCTTACTTTTAGAAGAGTTACTTGA

Upstream 100 bases:

>100_bases
AGAACTATTGCTGTTCATATTAGAAGAATTAGAGAAAAGATTGAAATTAATCCAAAAGAACCAAAATATTTAAAGGTGGT
GTGGGGCATTGGTTACAAAA

Downstream 100 bases:

>100_bases
TATATTAATATAAAAATATATTTTAAGTTATTTAAACAAGAAAAAAACCTCCTTAGAGGTCTTTTTCTAAATGTTGGGGT
TTATATTTACATATTTTTTG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNINYYYREFALPYFYFFGTPVHLSKVELEFVCIGIILSSFLL
TILCFTLYKKNKQTKVKFLENVISLFSKVKIELTLILTLILLTLRFHAFTSNKIFYNTNLIIYNFIIISIVYIIYENIKY
NNYNLKDMSITYVFFSNLLSMYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIY
NFLSVKFNYINNISKNIKNIENGNLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIKNERMKAELITNVSHDLKTPL
TSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKLSSGDVEFNITKTDIRELLIQSIVEFEDKIQNSS
LDFIIETPEYAVFTMIDGKKTWRVFENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGD
ISRKTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVT

Sequences:

>Translated_525_residues
MKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNINYYYREFALPYFYFFGTPVHLSKVELEFVCIGIILSSFLL
TILCFTLYKKNKQTKVKFLENVISLFSKVKIELTLILTLILLTLRFHAFTSNKIFYNTNLIIYNFIIISIVYIIYENIKY
NNYNLKDMSITYVFFSNLLSMYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIY
NFLSVKFNYINNISKNIKNIENGNLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIKNERMKAELITNVSHDLKTPL
TSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKLSSGDVEFNITKTDIRELLIQSIVEFEDKIQNSS
LDFIIETPEYAVFTMIDGKKTWRVFENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGD
ISRKTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVT
>Mature_525_residues
MKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNINYYYREFALPYFYFFGTPVHLSKVELEFVCIGIILSSFLL
TILCFTLYKKNKQTKVKFLENVISLFSKVKIELTLILTLILLTLRFHAFTSNKIFYNTNLIIYNFIIISIVYIIYENIKY
NNYNLKDMSITYVFFSNLLSMYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIY
NFLSVKFNYINNISKNIKNIENGNLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIKNERMKAELITNVSHDLKTPL
TSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKLSSGDVEFNITKTDIRELLIQSIVEFEDKIQNSS
LDFIIETPEYAVFTMIDGKKTWRVFENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGD
ISRKTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVT

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=25.6, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=217, Percent_Identity=24.4239631336406, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789149, Length=216, Percent_Identity=23.1481481481481, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61302; Mature: 61302

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNINYYYREFALPYFYFFGTPVH
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEE
LSKVELEFVCIGIILSSFLLTILCFTLYKKNKQTKVKFLENVISLFSKVKIELTLILTLI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTLRFHAFTSNKIFYNTNLIIYNFIIISIVYIIYENIKYNNYNLKDMSITYVFFSNLLS
HHHHHHHHEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
MYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFLSVKFNYINNISKNIKNIENGNLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIK
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCC
NERMKAELITNVSHDLKTPLTSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
IFEASKLSSGDVEFNITKTDIRELLIQSIVEFEDKIQNSSLDFIIETPEYAVFTMIDGKK
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCH
TWRVFENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGD
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC
ISRKTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVT
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLIINDSKAKFILLLLLFLLVSILFEAVYDLNNNFSNINYYYREFALPYFYFFGTPVH
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEE
LSKVELEFVCIGIILSSFLLTILCFTLYKKNKQTKVKFLENVISLFSKVKIELTLILTLI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTLRFHAFTSNKIFYNTNLIIYNFIIISIVYIIYENIKYNNYNLKDMSITYVFFSNLLS
HHHHHHHHEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
MYNKKTINKKLAIVFLISIVVQAIIQYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFLSVKFNYINNISKNIKNIENGNLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIK
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCC
NERMKAELITNVSHDLKTPLTSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
IFEASKLSSGDVEFNITKTDIRELLIQSIVEFEDKIQNSSLDFIIETPEYAVFTMIDGKK
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEECCCH
TWRVFENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGD
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCC
ISRKTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVT
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]