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The map label for this gene is lysA [H]

Identifier: 126699417

GI number: 126699417

Start: 2091249

End: 2092460

Strand: Direct

Name: lysA [H]

Synonym: CD1808

Alternate gene names: 126699417

Gene position: 2091249-2092460 (Clockwise)

Preceding gene: 126699415

Following gene: 126699418

Centisome position: 48.74

GC content: 25.08

Gene sequence:

>1212_bases
ATGTACTCAAATGAAGACTATAAATTTATAGAAGAAAATGCACCATGTTATATATATGATGAGACTAATATAATTGAAAA
ATGTAAGGAATTGAAAAATAATATTTTAGGTTTTGATTTTTTATATTCTATAAAAACAAATCCATATAACAAAATTGTAA
AAAGCATTGCAGAGCAAGGTTTTGGAGCAGATGCTTCTTCAACTAATGAAGTTATGATTTCATCAAAATGTGGAGTTTCT
AAAGATGATATTTATTATTCATCACCAGGCAAAACAGAGATTGATATAGAAACTGTTTTAGATAAATGCATAATTATTGC
AGATAGTATTACAGAAATAGAACTTATAAATAAGATATCTAAAAAGCATAATCAGAAAGTTAAAATAGGAATAAGAATAA
ATCCTGATTTTACTATGGATGATGATAGTGCTAAATCAAGCAAATTTGGTATAGATATAGAAGATATGAGCAGTGTTTTT
AAGATGTTAAGTATGTGTGATTATGTATCTGTAGTTGGTATTCATATACATATTAAATCTCAGGTATTGGATTTTGAAAA
GTTAGGACATTATTATGAAAAATGTTTTTTTATAGCTTTAAATTTAAATAAAAGTAAGTATATTAATATTGAATTTATAA
ATTTTGGTAGTGGACTTGGAGTAGCTTATGATAATCTTAGAGAAAATCCACTTAATCTTAAAGAGCTTTCAAAATTAACT
CAAAAGATTGCTTTTACTAATTCAAACACACTAAAATCAAGACTTCTTATTGAATCAGGACGTTTCATAGTTTGTAAATC
AGGTAATTATTATGTTAAAATTGTAGATATTAAAGTATCAAGAGGGAAAAAATATCTTATTGTAAAAAATGGACTTAATG
GATTTATGAGACCTATTATTTCTAATTTAATTGAAAATATTACTTGTGGAGTAGAATTAGAAGGTCAAGAGCCATTATAT
ACATCAAATCATGCCTTTTCTCTTTCAGTATTAAATAATTTAAAAGAAGAAGAGTATGTAAATGTTGTTGGGAATCTCTG
TACATCATTAGATGTAATTGCAAATAATGTTAAATTGAAAAAAGCAAACATAGGAGATTTGATTTCAATTAGTAATGCTG
GAAGTTACTCCTATTCTTTATCACCGCTATTATTTTCAAGTTATGAATTTCCTAAACAATATTATAAAAGAAAAGATGGA
TATATTGAGTAA

Upstream 100 bases:

>100_bases
ATATGTGTGTAGTTAACTATGGTAATTTATTGTAAAATTATCTTATAGGATTATAATTGCTTAATTTATGATTATATTTA
AAATCTTGGAGGTAAAAAAT

Downstream 100 bases:

>100_bases
ACAATAGCATAAATTAATAAACTTAGTATTATTGAAAAAATTTAAAATGCAGGGGGTGTAATTCTATATGGAATTGTGGA
AAAGAAATTTATTTGTATGT

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSIKTNPYNKIVKSIAEQGFGADASSTNEVMISSKCGVS
KDDIYYSSPGKTEIDIETVLDKCIIIADSITEIELINKISKKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSGLGVAYDNLRENPLNLKELSKLT
QKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVDIKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLY
TSNHAFSLSVLNNLKEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPKQYYKRKDG
YIE

Sequences:

>Translated_403_residues
MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSIKTNPYNKIVKSIAEQGFGADASSTNEVMISSKCGVS
KDDIYYSSPGKTEIDIETVLDKCIIIADSITEIELINKISKKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSGLGVAYDNLRENPLNLKELSKLT
QKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVDIKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLY
TSNHAFSLSVLNNLKEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPKQYYKRKDG
YIE
>Mature_403_residues
MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSIKTNPYNKIVKSIAEQGFGADASSTNEVMISSKCGVS
KDDIYYSSPGKTEIDIETVLDKCIIIADSITEIELINKISKKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSGLGVAYDNLRENPLNLKELSKLT
QKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVDIKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLY
TSNHAFSLSVLNNLKEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPKQYYKRKDG
YIE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI22538418, Length=398, Percent_Identity=22.3618090452261, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI21361583, Length=398, Percent_Identity=22.3618090452261, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1789203, Length=398, Percent_Identity=24.3718592964824, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562780, Length=403, Percent_Identity=23.5732009925558, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45588; Mature: 45588

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSIKTNPYNKIVKSIAEQG
CCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHC
FGADASSTNEVMISSKCGVSKDDIYYSSPGKTEIDIETVLDKCIIIADSITEIELINKIS
CCCCCCCCCEEEEECCCCCCCCCEEECCCCCCEEEHHHHHHHHEEEECCCHHHHHHHHHH
KKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVFKMLSMCDYVSVVGIHIHIKS
HHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEH
QVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSGLGVAYDNLRENPLNLKELSKLT
HHHCHHHHHHHHHEEEEEEEECCCCEEEEEEEEEECCCCCEEHHCCCCCCCCHHHHHHHH
QKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVDIKVSRGKKYLIVKNGLNGFMRPII
HHHHCCCCCHHHHEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEEEECCCCHHHHHHH
SNLIENITCGVELEGQEPLYTSNHAFSLSVLNNLKEEEYVNVVGNLCTSLDVIANNVKLK
HHHHHHCCCCEEECCCCCEEECCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEE
KANIGDLISISNAGSYSYSLSPLLFSSYEFPKQYYKRKDGYIE
ECCCCCEEEECCCCCCEEECCHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSIKTNPYNKIVKSIAEQG
CCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHC
FGADASSTNEVMISSKCGVSKDDIYYSSPGKTEIDIETVLDKCIIIADSITEIELINKIS
CCCCCCCCCEEEEECCCCCCCCCEEECCCCCCEEEHHHHHHHHEEEECCCHHHHHHHHHH
KKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVFKMLSMCDYVSVVGIHIHIKS
HHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEH
QVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSGLGVAYDNLRENPLNLKELSKLT
HHHCHHHHHHHHHEEEEEEEECCCCEEEEEEEEEECCCCCEEHHCCCCCCCCHHHHHHHH
QKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVDIKVSRGKKYLIVKNGLNGFMRPII
HHHHCCCCCHHHHEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEEEECCCCHHHHHHH
SNLIENITCGVELEGQEPLYTSNHAFSLSVLNNLKEEEYVNVVGNLCTSLDVIANNVKLK
HHHHHHCCCCEEECCCCCEEECCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEE
KANIGDLISISNAGSYSYSLSPLLFSSYEFPKQYYKRKDGYIE
ECCCCCEEEECCCCCCEEECCHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]