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The map label for this gene is argG

Identifier: 126699394

GI number: 126699394

Start: 2067107

End: 2068306

Strand: Direct

Name: argG

Synonym: CD1785

Alternate gene names: 126699394

Gene position: 2067107-2068306 (Clockwise)

Preceding gene: 126699393

Following gene: 126699395

Centisome position: 48.18

GC content: 31.33

Gene sequence:

>1200_bases
ATGAAGGAAAAAGTAGTATTAGCATATTCAGGAGGACTTGACACATCAATCATAATACCTTGGTTAAAGGAAAATTATGA
AGATATAGATGTTATAGCTGTTTGTGGAAATGTAGGTCAGGAAGATAAAATGGAAGATGTATATGAAAAAGCTTTACAAA
GTGGAGCATCAAAGGCATATGTGGATGATATAAGTGAAGAATTTGTAACTGAAACTATATTTAAAGCCGTAAAAGCAGAG
GCTAAATATGAAGGAAAATACTTATTAGGAACTTCTTTAGCAAGACCTATAATAGCTAAAAAATTAGTTGAAGTTGCTCA
TAAAGAAGGTGCAAAATATATATGCCATGGATGTACAGGAAAAGGTAATGACCAAGTTAGATTTGAAGCTACAATTGCAG
CTCTTGACCCAACTATAAAAGTTATTGCACCTTGGAGAATTTGGGATATAAAATCAAGAGAAGATGCTATAGACTATGCT
GAAAAACATAATATAAAGGTAACAGCAACTAAAGCTAAAATATATTCAGTAGATGCTAACCTTTGGCATGTTTCAACAGA
AGGTGGAGATATAGAGCACCTAGAAAATGAACATAAAAAAGATGTTTATAAACAATGTGTAGACCCAGAAGATGCATGTG
ATGTAGCTGAATATGTAGAAGTTTACTTTGAAAAAGGTGTACCTAAAAAGGTAAATGGCGAAGAATTATCTCCAGTTGCA
CTGATTCATAAGTTAAATGAGTTGGGTTGTAAACATGGAATTGGTGTTATAGATATAGTTGAGAATAGACTTGTTGGTAT
GAAATCAAGAGGTATATATGAGACTCCAGGAGGAACAATCCTTTATGAAGCACATAATATTTTAGAAAGTGCTACTTTAG
ACAAAGATACATTACATTTCAAACAAATGGTATCTTATAAATACGGAGAACTTATTTACAATGGACTATGGTATTGTAAA
TTAAGAGAATCTATAGATGCATTTATGGAACAAACTCAAGATAATGTTACAGGAACAGTAAAAGTTAAACTTTACAAAGG
AAATATAAAACCTGCTGGAATATTTACTGAAAATGCTCTTTATGATGAAGGAATATCTTCTTTTGGAAATAGTGAACTTT
ATGACCACAAAGATGCAGAAGGATTTATTAATTTATTCACTTTACCATTAAAAATCAGAGCTATGAAAGCTGGAAAATAA

Upstream 100 bases:

>100_bases
TATTAAAATGATTTTATGTGAGTCTAAATTCTCAGAGTCATTCAATATTAAGAATTTCTATAAAATAAAAATTATAATTT
AAGATTGGGAGGAATTAAAA

Downstream 100 bases:

>100_bases
TAAAATAAATTATTTAAGAGTGTATAAAAACTATTTTTAGGTTTTTATATGCTCTTTTTTTATTTGAATTTATTAAATTA
TATAGTAAATAGTATAAAAA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAE
AKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVA
LIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCK
LRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK

Sequences:

>Translated_399_residues
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAE
AKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVA
LIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCK
LRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK
>Mature_399_residues
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAE
AKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVA
LIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCK
LRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=399, Percent_Identity=46.1152882205514, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI16950633, Length=399, Percent_Identity=46.1152882205514, Blast_Score=338, Evalue=4e-93,
Organism=Escherichia coli, GI1789563, Length=369, Percent_Identity=28.4552845528455, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324514, Length=406, Percent_Identity=42.6108374384236, Blast_Score=293, Evalue=3e-80,
Organism=Drosophila melanogaster, GI21358151, Length=413, Percent_Identity=41.6464891041162, Blast_Score=292, Evalue=3e-79,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_CLOD6 (Q186Z6)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088291.1
- ProteinModelPortal:   Q186Z6
- SMR:   Q186Z6
- STRING:   Q186Z6
- GeneID:   4914984
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1785
- NMPDR:   fig|1496.1.peg.3022
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44624; Mature: 44624

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 87-87 BINDING 92-92 BINDING 117-117 BINDING 119-119 BINDING 123-123 BINDING 123-123 BINDING 124-124 BINDING 127-127 BINDING 176-176 BINDING 185-185 BINDING 261-261 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAY
CCCCEEEEECCCCCCEEEEEHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHH
VDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
KGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYAEKHNIKVTATKAKIYSVDAN
CCCCEEEEEEEEEEECCCEEEEECEEEEECCCCHHHHHHHHHCCEEEEEEEEEEEEECCC
LWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVA
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHF
HHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCEECCCCEEEEHHHHHHHHHCCCHHHHHH
KQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENAL
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCEEECCHH
YDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK
HHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEEEECCCC
>Mature Secondary Structure
MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKMEDVYEKALQSGASKAY
CCCCEEEEECCCCCCEEEEEHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHH
VDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKLVEVAHKEGAKYICHGCTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
KGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYAEKHNIKVTATKAKIYSVDAN
CCCCEEEEEEEEEEECCCEEEEECEEEEECCCCHHHHHHHHHCCEEEEEEEEEEEEECCC
LWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEYVEVYFEKGVPKKVNGEELSPVA
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETPGGTILYEAHNILESATLDKDTLHF
HHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCEECCCCEEEEHHHHHHHHHCCCHHHHHH
KQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQDNVTGTVKVKLYKGNIKPAGIFTENAL
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCEEECCHH
YDEGISSFGNSELYDHKDAEGFINLFTLPLKIRAMKAGK
HHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA