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The map label for this gene is moaA [H]

Identifier: 126699320

GI number: 126699320

Start: 1987405

End: 1988364

Strand: Direct

Name: moaA [H]

Synonym: CD1713

Alternate gene names: 126699320

Gene position: 1987405-1988364 (Clockwise)

Preceding gene: 126699319

Following gene: 126699321

Centisome position: 46.32

GC content: 26.77

Gene sequence:

>960_bases
ATGATTGATAAGTATGGAAGAAAAATAGACTACCTTCGTATTTCACTTACAGATAAGTGTAATTTAAGGTGTGTCTATTG
TATGCCACCAGATGTAAAATTTGATAAAAATTATATAAATGAAAATCTAAGCTTTGAAGACTACAAGTTTATTATAAAGG
CTATGGCTGAACAAGGTATAACAAAAATTAGATTTACTGGAGGAGAACCTCTTTTATATCCTAAATTAAATGAGCTTATA
AAATTTACAAAAGAAGAATGTGGAATAAATAACATAGGAATGACCACTAATGCTATTGGGCTTTCTGATAGAATCTTTGA
GCTTGAAAAATGTGGCTTAAATAAAGTTAATATAAGTTTAGATTCTTTGAAGGAATATAAGTATAAATCCGTAACAAGAG
GAGGAAACTTAAAAGATGTCTTAAAATCGATTGAATCTTGTTTAAACTTAGGTATAAAAGTAAAGTTAAATTGCGTTGCT
ATAAGTGGGTTTAATGATGATGAGCTTAAAGATTTTATGTTTTTAACAGTTAAATCACCAATTGATGTAAGATTTATAGA
GCTTATGCCATTAGGTGAGGCTAATAGAGTTTATAAGAAGGGTTATTTTAATGTAAAAGAAATGATTGAAAAAATATATG
GTTTATATAAAGTCAAAAATGATGAAAAAAGTACAGCAGAATATTATATGTTTAAAGGAGCTAAAGGAAGAATAGGAATT
ATAACTCCATTAAGCTGTTCATTTTGTAACACTTGTAATCGTATTAGACTTACTTCTAGTGGTGCAATAAAATTATGTCT
ACATTCAAAAGAAGAAATAGATATAAAACCATTTTTACATAAACCATTGTTATTTAGAGAATCTATGAAAGATATAATAA
AACAAAAACCAGAAAAACATCATTTAATAGAAAATAAATGTAGTGATACAAATAGGCGTATGTATGAAATTGGAGGATAA

Upstream 100 bases:

>100_bases
ATAGAAGTTTTAAGAGGAGAAGCTACAGAATGTGCCACTAAAAAAAGTGAATAGTATATAATCTAGATAGATAAAAAATA
GACAAAGAGGTAGATAAAGT

Downstream 100 bases:

>100_bases
GTAATGTTAACACATATAAATGAAAAAGGGTATGCCAAGATGGTGGACATAAGTGAAAAAGATGATACTAAAAGAACGGC
CGTAGCTACAGCTACAATTA

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLSFEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELI
KFTKEECGINNIGMTTNAIGLSDRIFELEKCGLNKVNISLDSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVA
ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKVKNDEKSTAEYYMFKGAKGRIGI
ITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIKPFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG

Sequences:

>Translated_319_residues
MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLSFEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELI
KFTKEECGINNIGMTTNAIGLSDRIFELEKCGLNKVNISLDSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVA
ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKVKNDEKSTAEYYMFKGAKGRIGI
ITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIKPFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG
>Mature_319_residues
MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLSFEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELI
KFTKEECGINNIGMTTNAIGLSDRIFELEKCGLNKVNISLDSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVA
ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKVKNDEKSTAEYYMFKGAKGRIGI
ITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIKPFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=37.6146788990826, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=37.6146788990826, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=29.3577981651376, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=326, Percent_Identity=34.6625766871166, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=325, Percent_Identity=34.7692307692308, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32566331, Length=280, Percent_Identity=37.1428571428571, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28574488, Length=328, Percent_Identity=35.6707317073171, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI28574490, Length=309, Percent_Identity=35.9223300970874, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36732; Mature: 36732

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLSFEDYKFIIKAMAEQGI
CCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCC
TKIRFTGGEPLLYPKLNELIKFTKEECGINNIGMTTNAIGLSDRIFELEKCGLNKVNISL
EEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEH
DSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVAISGFNDDELKDFMFLTVKSP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHCEEEEEEECCC
IDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKVKNDEKSTAEYYMFKGAKGRIGI
CCEEEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEEE
ITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIKPFLHKPLLFRESMKDIIKQKPEKH
ECCCCCHHHCCCCEEEEECCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHH
HLIENKCSDTNRRMYEIGG
HHHHHCCCCCCCEEEECCC
>Mature Secondary Structure
MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLSFEDYKFIIKAMAEQGI
CCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCC
TKIRFTGGEPLLYPKLNELIKFTKEECGINNIGMTTNAIGLSDRIFELEKCGLNKVNISL
EEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEH
DSLKEYKYKSVTRGGNLKDVLKSIESCLNLGIKVKLNCVAISGFNDDELKDFMFLTVKSP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHCEEEEEEECCC
IDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKVKNDEKSTAEYYMFKGAKGRIGI
CCEEEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEEE
ITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIKPFLHKPLLFRESMKDIIKQKPEKH
ECCCCCHHHCCCCEEEEECCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHH
HLIENKCSDTNRRMYEIGG
HHHHHCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA