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The map label for this gene is mepA [H]

Identifier: 126699145

GI number: 126699145

Start: 1789452

End: 1790843

Strand: Direct

Name: mepA [H]

Synonym: CD1541

Alternate gene names: 126699145

Gene position: 1789452-1790843 (Clockwise)

Preceding gene: 126699144

Following gene: 126699146

Centisome position: 41.71

GC content: 30.17

Gene sequence:

>1392_bases
ATGGAAAATCAACAATTATTAGGAACAGAACGAATTAGTAAATTACTACTAAAATATTCTATACCAGCTATAATAGGTAT
GTTGGTAAATAGTTTATATAATGTAGTAGATAGAATTTTTATTGGAAATATACCAGGGGTTGGACCACTTGCAATAACAG
GTCTTGGTGTAACAATGCCAATAATGACAATAATACTTGCATTTGGGATGTTGATAGGTATAGGAACTACTACTACCATA
TCAATAAAACTTGGGCAAGGTAAAGTAGAAGAGGCAAGAAAACTGATAGGAAATGCAATGACGTTATCTGTAATAACAGG
AATTATCATAATGATACTTGGAATATTATTTGCAAATAAAATACTTACATTGTTTGGAGCAAGTGAAAATACTTTAATAT
ATGCAAAATCATATATAAATATTATATTATTAGGTACAGTAGTAAATCTTCTTTCCTTTTCTTTAAACCACTCAATAAGA
GCTGATGGTAGTCCTAAAATTTCAGCAGGAATAATGATAGTAGGATGTTTAACTAATATAGTTTTAGACTGGATATTAAT
ATTTGGATTCAATTTGGGAATACAAGGAGCTGCAATTGCTACAGTAACTTCTCAGGCTCTTACAGCTATTTTAACTATAG
GGTATTATATAAGTGGAAAATCAAACTTACGATTCAGTAAATCTAATCTAAAATTAGATAAAAAGCTAATAAAAGCAGTG
TTTGCAATAGGTATGTCGCCATTTGCTATGCAACTTGCAGCAAGTTTAGTTCAAGTAATATCAAATATTGCACTTAAAAC
TCATGGTGGAGATTTAGCTATAGGGGCTATGGCTACTATTTCTTCTATTGCAATGGTATTTTTGATGCCTATCTTTGGAA
TAAATCAAGGAGCGCAACCTATTATAGGTTTCAATTATGGAGCTGAAAAATATGATAGGGTTAAAAAAGCATATTTAGGT
TCATTAGTAGTAGCTACTATAATTTTATGTATGGGTATGGTAGTAGTTATGCTTTTCCCAGAAGCTATTATAGGTATATT
TAATAAAGACCCTGAACTTATGAATATATCTGTTAATGGATTAAGAATATACTTACTTATGTTGCCAATTGTAGGCTTAT
CAGTTACAGGAACAAACTTTATACAATCTATAGGAAAAGCAAAAATGGCTATGTTATTGAGCCTTTTAAGACAAGTAATT
TTATTGATACCAGCAGTATTAATTCTTCCTACATTCTTAGGTTTACAGGGTGTATGGACAGCTCAACCAGTGTCTGATTT
TATAGCTACAGTAATTACAGGTATAGTTGTATTTAGAGAATTAAAAAGATATACTCCTAAAACTGAAAAATTAAATGAAA
ATGAAAGACTAAACGAGATAACTACTGAGTAA

Upstream 100 bases:

>100_bases
TATAAATTAATATTTAAAAAGTAGTTAATATTAGGGGAGGGCATTTGCACCTCCCTTGTAATATGTGGAAAATTGAATAT
TAGAAGAAGGAGGAGACTTG

Downstream 100 bases:

>100_bases
AAATATAAATTCAGATAATTGAGCAAGAAATTGCAAAAAATACGATTATATGATAAAATAAAACCGCTGTCAAGGATAAG
AGAAATTCTAATTATGGAGT

Product: drug/sodium antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNIPGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTI
SIKLGQGKVEEARKLIGNAMTLSVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYISGKSNLRFSKSNLKLDKKLIKAV
FAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGAMATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLG
SLVVATIILCMGMVVVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAMLLSLLRQVI
LLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEKLNENERLNEITTE

Sequences:

>Translated_463_residues
MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNIPGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTI
SIKLGQGKVEEARKLIGNAMTLSVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYISGKSNLRFSKSNLKLDKKLIKAV
FAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGAMATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLG
SLVVATIILCMGMVVVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAMLLSLLRQVI
LLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEKLNENERLNEITTE
>Mature_463_residues
MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNIPGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTI
SIKLGQGKVEEARKLIGNAMTLSVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYISGKSNLRFSKSNLKLDKKLIKAV
FAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGAMATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLG
SLVVATIILCMGMVVVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAMLLSLLRQVI
LLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEKLNENERLNEITTE

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49754; Mature: 49754

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNIPGVGPLAITGLGVTMP
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHH
IMTIILAFGMLIGIGTTTTISIKLGQGKVEEARKLIGNAMTLSVITGIIIMILGILFANK
HHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIRADGSPKISAGIMIVGCLTNI
HHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYISGKSNLRFSKSNLKLDKKLIKAV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEECHHHHHHHHHHHHHH
FAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGAMATISSIAMVFLMPIFGINQGAQP
HHHCCCHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIGFNYGAEKYDRVKKAYLGSLVVATIILCMGMVVVMLFPEAIIGIFNKDPELMNISVNG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECH
LRIYLLMLPIVGLSVTGTNFIQSIGKAKMAMLLSLLRQVILLIPAVLILPTFLGLQGVWT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AQPVSDFIATVITGIVVFRELKRYTPKTEKLNENERLNEITTE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNIPGVGPLAITGLGVTMP
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHH
IMTIILAFGMLIGIGTTTTISIKLGQGKVEEARKLIGNAMTLSVITGIIIMILGILFANK
HHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIRADGSPKISAGIMIVGCLTNI
HHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYISGKSNLRFSKSNLKLDKKLIKAV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEECHHHHHHHHHHHHHH
FAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGAMATISSIAMVFLMPIFGINQGAQP
HHHCCCHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIGFNYGAEKYDRVKKAYLGSLVVATIILCMGMVVVMLFPEAIIGIFNKDPELMNISVNG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECH
LRIYLLMLPIVGLSVTGTNFIQSIGKAKMAMLLSLLRQVILLIPAVLILPTFLGLQGVWT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AQPVSDFIATVITGIVVFRELKRYTPKTEKLNENERLNEITTE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA