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The map label for this gene is cytR [H]

Identifier: 126698262

GI number: 126698262

Start: 827202

End: 828224

Strand: Direct

Name: cytR [H]

Synonym: CD0683

Alternate gene names: 126698262

Gene position: 827202-828224 (Clockwise)

Preceding gene: 126698261

Following gene: 126698264

Centisome position: 19.28

GC content: 33.24

Gene sequence:

>1023_bases
ATGAATCAAAAGAAAGTTCATTATAATAAATCGGCTACCTCAAAAGATGTTGCAAGATTGGCAGGAGTATCTCAATCATC
TGTTTCAAGAGCATTTGGTAGTGCAAATGGAAAGGGCGTAAAACCTGAAGTAAGAGAAAGAATTTTTCGTGTAGCAAACG
AAATAGGATATGTTCCTAATTTGGTAGCACGGGGAATGATTAGTGGAAAAACTAATGTTATAGGATTGATAGTTGGTGAT
AGTCTAGGTCCATTTTACAATAGAATTATCAATTTATTTGTAGAAAAAATTCAAGAGATAGGTAAACAGTGTCTCGTTTT
TAAAGTTCCTAGACAACAAAGTATAGATAGTATAATTTCAAAAGTAATTCAGTTTCAAGTAGAAGCTGTGATTATTACAG
CTTCGGCCATGAATAAGGTGATGGCTGAGACTTGTGAAGAAAACAATATTCCTGTGATTCTTTTTAATCGTTTTATACCT
GGTATAAAAATAAGTACAGTCTATGTAGACCCAATTGAAGGTGGGGGAATGGCTGCTGAATATCTGCTTAAGAAAGGTCA
TAAGAATATAGGATATATTCAATTTACGAGAGAAACAAGTGAAGAAATGGAAAAGAAAATTGGATTTTATTCTAAGTTAA
GACAAAGTGGGATTCATAACCTTAAAGAAGAATCTGCAAACTATGATTATGATTCTGGTTATGAAGCAGGTAAGAGAATG
TTAGCATTATCAAATCCTCCAACAGCAATTTTTTGCACAAGTGACTTGATAGCTATTGGTGTAATGGATGCTGCAAGGTT
TGAGTACAAGTTGAGGGTGCCAGAGGATTTATCAGTGATAGGATATGATGATATTCAAATGGCTTCATGGAAGAGTTATA
ATTTAACGACGATTAGACAGCCACTAGATTTGTTGATTGAAAAAACAATTAACATACTTAAGTCCTTATTAAATGAAGAA
AATCCAGAGTCAGTCGTTGAAATGTTAAAACCTGAATTGATTGAAAGAGGTTCTACACTTTAA

Upstream 100 bases:

>100_bases
CAAGAACTAATTGTATTAGCTTTTTTTATTATCCAATATATTATATTATTTTTGATACAATTTTAAGAAGAAATACTAGA
TATTTAAGGAGAAATACTAA

Downstream 100 bases:

>100_bases
GTGGTAGATATTTAATTAAGTGGTAGATATTTAATTAAGTGGTAGATATTTAATTAAGTGGTAGATATTTAATTAAGTGG
TAGATATTTAATCAAGTGAT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEVRERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGD
SLGPFYNRIINLFVEKIQEIGKQCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGIHNLKEESANYDYDSGYEAGKRM
LALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPEDLSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEE
NPESVVEMLKPELIERGSTL

Sequences:

>Translated_340_residues
MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEVRERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGD
SLGPFYNRIINLFVEKIQEIGKQCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGIHNLKEESANYDYDSGYEAGKRM
LALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPEDLSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEE
NPESVVEMLKPELIERGSTL
>Mature_340_residues
MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEVRERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGD
SLGPFYNRIINLFVEKIQEIGKQCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGIHNLKEESANYDYDSGYEAGKRM
LALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPEDLSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEE
NPESVVEMLKPELIERGSTL

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=31.8318318318318, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1790194, Length=332, Percent_Identity=28.0120481927711, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=30.2395209580838, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1789202, Length=330, Percent_Identity=26.0606060606061, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=29.2929292929293, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=27.2435897435897, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786540, Length=334, Percent_Identity=25.748502994012, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787580, Length=292, Percent_Identity=26.3698630136986, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786268, Length=329, Percent_Identity=25.8358662613982, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789456, Length=344, Percent_Identity=26.1627906976744, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787906, Length=257, Percent_Identity=26.4591439688716, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790715, Length=300, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994940, Length=304, Percent_Identity=22.0394736842105, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37913; Mature: 37913

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEVRERIFRVANEIGYVPN
CCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHH
LVARGMISGKTNVIGLIVGDSLGPFYNRIINLFVEKIQEIGKQCLVFKVPRQQSIDSIIS
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHH
KVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIPGIKISTVYVDPIEGGGMAAE
HHHHHHHHHEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHH
YLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGIHNLKEESANYDYDSGYEAGKRM
HHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEE
LALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPEDLSVIGYDDIQMASWKSYNLTTIRQ
EEECCCCCEEEECCCHHHHHHHHHHHEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHH
PLDLLIEKTINILKSLLNEENPESVVEMLKPELIERGSTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEVRERIFRVANEIGYVPN
CCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHH
LVARGMISGKTNVIGLIVGDSLGPFYNRIINLFVEKIQEIGKQCLVFKVPRQQSIDSIIS
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHH
KVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIPGIKISTVYVDPIEGGGMAAE
HHHHHHHHHEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHH
YLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGIHNLKEESANYDYDSGYEAGKRM
HHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEE
LALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPEDLSVIGYDDIQMASWKSYNLTTIRQ
EEECCCCCEEEECCCHHHHHHHHHHHEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHH
PLDLLIEKTINILKSLLNEENPESVVEMLKPELIERGSTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]