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The map label for this gene is dnaH [H]

Identifier: 126697582

GI number: 126697582

Start: 20470

End: 22107

Strand: Direct

Name: dnaH [H]

Synonym: CD0016

Alternate gene names: 126697582

Gene position: 20470-22107 (Clockwise)

Preceding gene: 126697581

Following gene: 126697583

Centisome position: 0.48

GC content: 27.23

Gene sequence:

>1638_bases
ATGCATAAAGCATTATATAGAGCATATAGACCACAAAAATTTGAAGATGTTATTGGTCAAGATCATATTATTAAGACTTT
AAAGAATCAAATATATAGTGATAATATAGGACATGCTTATTTGTTTTGTGGAACAAGAGGTACTGGTAAAACATCTACTG
CAAAGATTTTTTCAAGAGCAGTAAACTGTTTGAATAAAATAAATGAAGAACCGTGTAATGAGTGTGAGATATGCGAATCT
GTATTAAAAGATAATACAATGGATGTTGTAGAAATAGATGCAGCTTCAAATAATAGTGTAGATGATATAAGAGAGCTTAG
AGAAAGTGTGAAATATTCTCCAGCCAATGCTAAATATAAAGTATATATAATAGATGAAGTTCATATGTTGTCTCAAGGAG
CTTTTAATGCATTATTAAAGACCTTAGAGGAACCTCCATCATATGTAATTTTTATATTAGCAACTACAGAGCCTCACAAA
ATACCTGCAACCATTTTATCAAGATGCCAAAGATACGATTTTAAAAGAGTTACAGTTAAAGATATGACCCTTAGAATGAA
AAAGATTTGTGAAGATGAAGGAATTGATATAGATGATAAAGCTCTTAATTTAATAGCTAGAAATTCTCAAGGAGCTCTTA
GAGATGCACTTAGTATATTAGACCAATGTATGTCTTTTGGAGAAAGTAAGATAGATTATAAAGATGTTGTTGAATTAATG
GGAAGCGTAAATATAGAACAATTATTTGAATTGTCTCAATGTATTGTAGAGCAGGACACTAAAAAGTCTCTTGAGATATT
AAATGAATTTGTCTTATGGGGCAAAGATATAAGAAATCTTATAAATGACTTAATTGATCATTTTAGAAATTTAATGGTAT
GTAAGGTTTCATCAGAATTGGATGAAATAATTTCATTACCAGAAGAAACTATAGAACAACTTAAAATTCAGTCTAAAAAT
ATAGATATAAATGATTTAATAAGGATTTTAAATATATTATCAATAACTCAGGATGATATAAAGTCATCTTCAAATCCAAG
GGTTTTAGTGGAAATAACCATAATGAAAATTGCTCAACCAATGTTTGATGAAAGTAAAGAAGCTCTTATAAAAAGAGTTG
AGAACTTAGAAAAAATGATTGAACTGGGGAACTTTAAGTCTGAAAAAATTGGGAATAATAAAGAAAAAGAGTATGAGGTC
GATAGAGAAATAGATGTAAAACAAGAAAATGTAGTTTATGAAGATGTAAAAAATGAGGATGTTATACTTATAGAGTCATC
TTGGAAGAATATACTTAAACAAATTAAAAAAGATAAAAAAATGCCAATATACGCACTCTTAAGTGAAGTAAAAAGTTTTA
ATGTATATTCTAATATGTTGTATGTTATATTTGATGATAAATTTGATTTTGCAAAAACTAGACTGAGCTCTCAAGATACA
ATAAATTATTTAGAAAAAACAATAAGAGATGTTTTAAATAGAAGTTTTAATGTAAAAATAGTACTGACATCAGAAGTTAA
AGATATAAATCTTGAAGTTAAAGAGAAAAAGGACATTGGTGAGGAAATATTAAAGAACATAGTGAGTGAAGAGATATTAG
AAATAAAAGATAGTATTGATGAAAATGAGAGTAAATAA

Upstream 100 bases:

>100_bases
ATTAAGTCGATAGATGGTGTACAGCATTTAATATATAAAAGACTAATCCCTTAGATAATGAGGGATTTTTTTATTAATTT
TGCTAAAGAGAGGTAAAAAG

Downstream 100 bases:

>100_bases
TAAAATACTATTATGATATAATAATAAAATGAAAATAAGTTTAGGAGGAATAGTGTTTATGGCTAAAAAAGGTTTTGGAG
GCGGAATGATGCCTGGTGGT

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCGTRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICES
VLKDNTMDVVEIDAASNNSVDDIRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALSILDQCMSFGESKIDYKDVVELM
GSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKDIRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKN
IDINDLIRILNILSITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGNNKEKEYEV
DREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEVKSFNVYSNMLYVIFDDKFDFAKTRLSSQDT
INYLEKTIRDVLNRSFNVKIVLTSEVKDINLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK

Sequences:

>Translated_545_residues
MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCGTRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICES
VLKDNTMDVVEIDAASNNSVDDIRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALSILDQCMSFGESKIDYKDVVELM
GSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKDIRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKN
IDINDLIRILNILSITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGNNKEKEYEV
DREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEVKSFNVYSNMLYVIFDDKFDFAKTRLSSQDT
INYLEKTIRDVLNRSFNVKIVLTSEVKDINLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK
>Mature_545_residues
MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCGTRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICES
VLKDNTMDVVEIDAASNNSVDDIRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALSILDQCMSFGESKIDYKDVVELM
GSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKDIRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKN
IDINDLIRILNILSITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGNNKEKEYEV
DREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEVKSFNVYSNMLYVIFDDKFDFAKTRLSSQDT
INYLEKTIRDVLNRSFNVKIVLTSEVKDINLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI194306571, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI194306567, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI6677723, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI31563534, Length=331, Percent_Identity=23.8670694864048, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4506491, Length=288, Percent_Identity=22.9166666666667, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI31881687, Length=288, Percent_Identity=22.9166666666667, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786676, Length=356, Percent_Identity=36.5168539325843, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1787119, Length=231, Percent_Identity=26.4069264069264, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=241, Percent_Identity=25.7261410788382, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=213, Percent_Identity=25.8215962441315, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=288, Percent_Identity=24.6527777777778, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=297, Percent_Identity=24.5791245791246, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324039, Length=265, Percent_Identity=25.6603773584906, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=239, Percent_Identity=23.8493723849372, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859927, Length=271, Percent_Identity=27.3062730627306, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647857, Length=342, Percent_Identity=24.5614035087719, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921076, Length=223, Percent_Identity=25.1121076233184, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62808; Mature: 62808

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCGTRGTGKTSTAKIFSRA
CCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHH
VNCLNKINEEPCNECEICESVLKDNTMDVVEIDAASNNSVDDIRELRESVKYSPANAKYK
HHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
VYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHKIPATILSRCQRYDFKRVTVK
EEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEHHH
DMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALSILDQCMSFGESKIDYKDVVELM
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKDIRNLINDLIDHFRNLMVCKVSSEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHH
DEIISLPEETIEQLKIQSKNIDINDLIRILNILSITQDDIKSSSNPRVLVEITIMKIAQP
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCCCEEEEEEHHHHHHHH
MFDESKEALIKRVENLEKMIELGNFKSEKIGNNKEKEYEVDREIDVKQENVVYEDVKNED
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHCCHHHCCCCCC
VILIESSWKNILKQIKKDKKMPIYALLSEVKSFNVYSNMLYVIFDDKFDFAKTRLSSQDT
EEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHCCCHHH
INYLEKTIRDVLNRSFNVKIVLTSEVKDINLEVKEKKDIGEEILKNIVSEEILEIKDSID
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
ENESK
CCCCC
>Mature Secondary Structure
MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCGTRGTGKTSTAKIFSRA
CCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHH
VNCLNKINEEPCNECEICESVLKDNTMDVVEIDAASNNSVDDIRELRESVKYSPANAKYK
HHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
VYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHKIPATILSRCQRYDFKRVTVK
EEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEHHH
DMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALSILDQCMSFGESKIDYKDVVELM
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKDIRNLINDLIDHFRNLMVCKVSSEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHH
DEIISLPEETIEQLKIQSKNIDINDLIRILNILSITQDDIKSSSNPRVLVEITIMKIAQP
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCCCEEEEEEHHHHHHHH
MFDESKEALIKRVENLEKMIELGNFKSEKIGNNKEKEYEVDREIDVKQENVVYEDVKNED
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHCCHHHCCCCCC
VILIESSWKNILKQIKKDKKMPIYALLSEVKSFNVYSNMLYVIFDDKFDFAKTRLSSQDT
EEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHCCCHHH
INYLEKTIRDVLNRSFNVKIVLTSEVKDINLEVKEKKDIGEEILKNIVSEEILEIKDSID
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
ENESK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]