Click here to switch to the map view.

The map label for this gene is mscS [H]

Identifier: 126697579

GI number: 126697579

Start: 16612

End: 17493

Strand: Direct

Name: mscS [H]

Synonym: CD0013

Alternate gene names: 126697579

Gene position: 16612-17493 (Clockwise)

Preceding gene: 126697578

Following gene: 126697580

Centisome position: 0.39

GC content: 25.4

Gene sequence:

>882_bases
ATGAATTTTTTATCATTGGCTAAGACTGCCTCAACAAATAGCAATATAACTAAGAGAACTTTAGAAAATATGCTCGATAA
TTTTAGTGATAATATACCAAATATTATATATGCAATAATTGTATTTGTGATAGGTATTTATATATCTAAAATAGTAAGAA
GGATGGTTTCAAAGTTTCTAATCAAATATGGAATGAGTAAAGGTGTAAATAATTTTATTGTATATGGAATATATATATCT
ATGTTATCTATTATATCATTGATAAGCTTAGGTATTATAGGGATACAAACTACATCAGTTGTAGCTGTGTTAGGAGCTGC
TGGATTTAGTATAGGTTTAGCTTTTAAAGAAATATTATCAAATTTAGGCTCTGGTATGATTATTTTATTTTTTAAGCCAT
TTAATATAGGTGATTATATTCAAGGTTCAGGTGTAGAAGGTACAGTTTCTGACATACAAATATTTAGCACTGTTCTTAAG
ACGCCAGATAATAAAACTATAATTATACCTAATTTTCAACTGACAAGTAATAATATAATTAATTACACACATCAAAACAA
AAGAAGAATAGATTTTTCATATAATATTTCATATGATAGTGATATAGATGTAGTTAAGTCTACATTAAATGAAATTTTTA
CAAACGAAAAAAGAATATTAAATGATCCAAAGCCTATAATAGGTTTAAACTCTATAGGAAATAACACCATGCAAATAGTT
GCTAGACCTTGGGTAAAAACTGATGATTACTGGGATGTATATTTTGATGTAATGGAAAAGGTAAAAAATAAATTTGATGA
GAATGATATAAAAGTTCCATTTGTTCCTTCTTCATTATTATTTAATAATACAGGTAATCTAAATACAATGGATAAAAGAT
AA

Upstream 100 bases:

>100_bases
GTAGCCATATTCATACAATTGAGGCAATAAAAGAAGAAACTATAGAAGCTATAGTAAAAGAGTTAAAGGACAACGGAATA
TTATCATAAGGAGGAGTTGA

Downstream 100 bases:

>100_bases
GGTCTTAATTAAATAGAAAAAATGAATTTAATATAAAAAATTAAAGAAAATTCTAAAAAAATTTGAATAATAGTATTGAA
AGATGTTAATATATATAATA

Product: mechanosensitive ion channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVIGIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYIS
MLSIISLISLGIIGIQTTSVVAVLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSTLNEIFTNEKRILNDPKPIIGLNSIGNNTMQIV
ARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVPSSLLFNNTGNLNTMDKR

Sequences:

>Translated_293_residues
MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVIGIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYIS
MLSIISLISLGIIGIQTTSVVAVLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSTLNEIFTNEKRILNDPKPIIGLNSIGNNTMQIV
ARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVPSSLLFNNTGNLNTMDKR
>Mature_293_residues
MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVIGIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYIS
MLSIISLISLGIIGIQTTSVVAVLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSTLNEIFTNEKRILNDPKPIIGLNSIGNNTMQIV
ARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVPSSLLFNNTGNLNTMDKR

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=241, Percent_Identity=38.1742738589212, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI1786670, Length=225, Percent_Identity=29.3333333333333, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787591, Length=199, Percent_Identity=26.1306532663317, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367355, Length=197, Percent_Identity=24.3654822335025, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 32896; Mature: 32896

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVIGIYISKIVRRMVSKFL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKYGMSKGVNNFIVYGIYISMLSIISLISLGIIGIQTTSVVAVLGAAGFSIGLAFKEILS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
NLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLKTPDNKTIIIPNFQLTSNNII
HCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECEEECCCCEE
NYTHQNKRRIDFSYNISYDSDIDVVKSTLNEIFTNEKRILNDPKPIIGLNSIGNNTMQIV
EEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCEEEEE
ARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVPSSLLFNNTGNLNTMDKR
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVIGIYISKIVRRMVSKFL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKYGMSKGVNNFIVYGIYISMLSIISLISLGIIGIQTTSVVAVLGAAGFSIGLAFKEILS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
NLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLKTPDNKTIIIPNFQLTSNNII
HCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECEEECCCCEE
NYTHQNKRRIDFSYNISYDSDIDVVKSTLNEIFTNEKRILNDPKPIIGLNSIGNNTMQIV
EEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCEEEEE
ARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVPSSLLFNNTGNLNTMDKR
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]