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The map label for this gene is serS1 [H]

Identifier: 126697580

GI number: 126697580

Start: 17952

End: 19223

Strand: Direct

Name: serS1 [H]

Synonym: CD0014

Alternate gene names: 126697580

Gene position: 17952-19223 (Clockwise)

Preceding gene: 126697579

Following gene: 126697581

Centisome position: 0.42

GC content: 30.9

Gene sequence:

>1272_bases
ATGTTAGATATTAAAAGAATAAGAGAAAATCTAGATGATATCAAAAAAGCTATGGAAAGAAGAGGTGAAAGAGAATTTGA
CCTTGATGCTGTAGTGGAATTAGATAATAAAAGAAGAGAAATACTTCAAGAAGTTGAAGTTATGAAAAATGAGTTAAATG
TAAATTCTAAAAAAATACCTCAATTAATAAAAGAAGGAAAAGATGTAACAGAAGAAAAGGCAAGATTGAAAGAGTTATCA
GATAAGATAAAAGGTATTGATGAGAAAGTAAAAGAAGTAGAAGCAAAAATGGAATATACATTAATGAGAATACCAAATGT
TCCTCATCCAGAGGTACCACAAGGTGAAACAGATGAAGACAATGTTCAAATAAGAACTTGGGGAGAACCTACTAAATTTG
ATTTTGAGCATAAAGCGCATTGGGATATAGGTACAGGTCTAGGTATTTTAGATTTTGAAAGAGCAGGGAAAATAACTGGG
TCAAGGTTTACTTTATATAGGGGATTAGGAGCTAGATTAGAAAGATCTTTAATGAATTTCTTTTTAAATACTCATACAGC
TAAGCATGGCTATACGGAAGTCTTACCTCCATTTATGGCCAATAGAAATAGTTTTATAGGGACTGGTCAACTTCCTAAAT
TTGAAGAAGATATGTTTAAAATAGAAGGATTAGAGTATTTCTTAATACCAACAGCTGAAGTTCCTGTTACTAATATACAT
GCTAATGAAATATTAGATGTTGCAGAGCTTCCAATTAAATACTGTGCATATACTCCTTGTTTTAGATCTGAAGCAGGTTC
AGCAGGAAGAGATACAAGAGGTTTAGTTAGACAACATCAATTTAATAAAGTTGAATTAGTTAAATTTGTTAAACCAGAAG
ATTCTTATAATGAATTAGAATCATTAACTCATGATGCTGAAACTATGTTACAAATGTTAGGTCTTCCATATAGAGTTGTA
AAAATATGTACAGGAGATTTGGGATTTACAGCTGCATTTAAATATGATTTAGAAGTTTGGATGCCAAGCTACAATAGATA
TGTAGAAATATCTTCTTGTTCAAATTTTGAAGATTTCCAAGCAAGAAGAGCAGGAATAAGATTTAAAAGGGATAAAAAAT
CAAAAGCAGAATATGTTCATACATTAAATGGTTCTGGATTAGCGATAGGAAGATGTTTGGCTGCTATATTAGAAAATTAT
CAGCAGGCAGATGGTTCTGTAGTAGTTCCAGAAGAATTAAGACCTTATATGGGTGTTGATGTTATAAAATAA

Upstream 100 bases:

>100_bases
ATTTTTAAAATTTGTTTAAACTAAGAGTTTACAAGTATAATGTTTGTAAATTAAGTTGGAATTATAACTTATATTATCAA
AATTATTAGGAGGAATTAAT

Downstream 100 bases:

>100_bases
ATTTATATTAATTGTATATGTAGAGTATGCTTTGATGAAGAGAATATATTATGAGTAAACAATAAATAAAAAAACTATGA
AATTATTATAAATATTAATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQEVEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELS
DKIKGIDEKVKEVEAKMEYTLMRIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDMFKIEGLEYFLIPTAEVPVTNIH
ANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLVRQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVV
KICTGDLGFTAAFKYDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRCLAAILENY
QQADGSVVVPEELRPYMGVDVIK

Sequences:

>Translated_423_residues
MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQEVEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELS
DKIKGIDEKVKEVEAKMEYTLMRIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDMFKIEGLEYFLIPTAEVPVTNIH
ANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLVRQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVV
KICTGDLGFTAAFKYDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRCLAAILENY
QQADGSVVVPEELRPYMGVDVIK
>Mature_423_residues
MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQEVEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELS
DKIKGIDEKVKEVEAKMEYTLMRIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDMFKIEGLEYFLIPTAEVPVTNIH
ANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLVRQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVV
KICTGDLGFTAAFKYDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRCLAAILENY
QQADGSVVVPEELRPYMGVDVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=346, Percent_Identity=37.2832369942197, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI8923421, Length=437, Percent_Identity=30.2059496567506, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI225579074, Length=439, Percent_Identity=30.751708428246, Blast_Score=198, Evalue=8e-51,
Organism=Escherichia coli, GI1787120, Length=424, Percent_Identity=47.877358490566, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=31.8965517241379, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=332, Percent_Identity=29.5180722891566, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321799, Length=427, Percent_Identity=33.2552693208431, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320226, Length=444, Percent_Identity=33.7837837837838, Blast_Score=222, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24581334, Length=451, Percent_Identity=32.1507760532151, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17737985, Length=337, Percent_Identity=32.0474777448071, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48527; Mature: 48527

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQEVEVMKNELNVNSKKIP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLIKEGKDVTEEKARLKELSDKIKGIDEKVKEVEAKMEYTLMRIPNVPHPEVPQGETDED
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
NVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITGSRFTLYRGLGARLERSLMNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDMFKIEGLEYFLIPTAEVPVTNIH
HHHHCCCCCCCHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCEECCC
ANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLVRQHQFNKVELVKFVKPEDSYNELE
HHHHHHHHHCCHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHH
SLTHDAETMLQMLGLPYRVVKICTGDLGFTAAFKYDLEVWMPSYNRYVEISSCSNFEDFQ
HHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHHHH
ARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRCLAAILENYQQADGSVVVPEELRPYMGVD
HHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCC
VIK
CCC
>Mature Secondary Structure
MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQEVEVMKNELNVNSKKIP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLIKEGKDVTEEKARLKELSDKIKGIDEKVKEVEAKMEYTLMRIPNVPHPEVPQGETDED
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
NVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITGSRFTLYRGLGARLERSLMNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCEEHHHHHHHHHHHHHHHHH
FLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDMFKIEGLEYFLIPTAEVPVTNIH
HHHHCCCCCCCHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCEECCC
ANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLVRQHQFNKVELVKFVKPEDSYNELE
HHHHHHHHHCCHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHH
SLTHDAETMLQMLGLPYRVVKICTGDLGFTAAFKYDLEVWMPSYNRYVEISSCSNFEDFQ
HHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHHHH
ARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRCLAAILENYQQADGSVVVPEELRPYMGVD
HHHHCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCC
VIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA