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The map label for this gene is aroP [H]

Identifier: 126447392

GI number: 126447392

Start: 1697608

End: 1698993

Strand: Reverse

Name: aroP [H]

Synonym: BMA10247_A1763

Alternate gene names: 126447392

Gene position: 1698993-1697608 (Counterclockwise)

Preceding gene: 126446384

Following gene: 126446236

Centisome position: 72.21

GC content: 65.01

Gene sequence:

>1386_bases
ATGGCAACAGATCAGGACAACGACGGCCTCAAGCGGGGGCTGAAGAATCGCCACATTCAACTGATCGCGCTCGGCGGCGC
GATCGGCACCGGGCTTTTCCTCGGCATTGCCCAGACGATTCGGATGGCGGGGCCGTCGGTGCTGCTCGGCTATGCGCTCG
CCGGCGTCGTCGCGTTCTTCATCATGCGGCAACTGGGCGAGATGGTCGTCGACGAGCCCGTCGCCGGCTCGTTCAGCTAT
TTCGCGAGTAAATACTGCGGGCACTTCACGGGCTTCCTGTCCGGCTGGAACTACTGGGTGCTGTACGTGCTCGTCAGCAT
GGCCGAGCTGTCCGCGGTCGGCATCTATGTGCAGTACTGGTGGCCCGGCGTGCCGACCTGGATCTCCGCGCTCGTGTTCT
TCGTCGTGATCAACGCGGTCAACCTCGCGAGCGTCAAGTCGTATGGCGAGACCGAGTTCTGGTTTTCGATCGTCAAGGTC
GCCGCGATCATCGGGATGATCGGCTTCGGCGGCTATCTGCTGCTGTCGGGGCACGCGGGCCCGGACGCCGGCGTCGCGAA
CCTGTGGCGGCACGGCGGCTTCTTCCCGAACGGCATCGGGGGCCTCGCGATGGCGATGGCGGTCATCATGTTCTCGTTCG
GCGGCCTCGAGCTCGTCGGCATCACGGCCGCGGAGGCGGACGATCCGTCGCACAGCATCCCGCGCGCGACGAACCAGGTG
ATCTACCGCATCCTGATTTTCTACATCGGCGCGCTCGGCGTGCTGCTGTCGCTGTATCCGTGGCAGAAGGTGGTGACGGG
CGGCAGCCCGTTCGTGCTGATCTTCCATGCGCTGTCGAGCGACATCGCCGCGAACGTGCTGAACCTCGTCGTGCTGACGG
CCGCGCTGTCGGTCTACAACAGCTGCGTGTACTGCAACAGCCGGATGCTGTACGGCCTCGCGCAGCAGGGCAACGCGCCG
CAGGCGCTCGCGCGCGTGAACCGGCGCGGCATTCCGATCGCGGCGCTCGGCGTGTCGGCGTTCGCGACCGCGCTGTGCGT
CGTGATCAACTATTTCATGCCGGGCAAAGCGTTCGAATTGTTGATGGGGCTCGTCGTATCGGCGATCATCATCAACTGGG
CCATGATCAGCGTGATTCATCTGCGGTTTCGTCAGGCGAAACGCGCGGCGGGCGAGACGACGCGCTTCCGGAGTCTCGGC
TATCCGCTGACGAACTATTTCTGTCTCGCCTTCATGGCGGCCATTCTCGTCGTCATGTTCCGTACGCCGGAGCTGCGCCT
GTCGGTCTACCTGATCCCCGTGTGGCTCGTCGTGCTCGCGCTCGGCTACCGGTTCCGCCAGCGCGGCGCCGGCTATGCAC
TCGGCGGCGGCGTATCGGCCCGTTGA

Upstream 100 bases:

>100_bases
CGCCGCGACATCCGCGCGGGCGGCCGGAAACAAGTACACGGCGCCCGGGCCGACCCGAAGGCGCGCCGCCTCCACAAAGG
GCGGATGAGACGGAGAAGAC

Downstream 100 bases:

>100_bases
TTCCGTTTTTTCCTTCATTGTAGAAACCGCCATGTTTGAACACATCGATGCCTACCCCGGCGATCCGATTCTCACGCTGA
ACGAGAACTTTCAGCAGGAC

Product: aromatic amino acid transport protein AroP

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSY
FASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYWWPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKV
AAIIGMIGFGGYLLLSGHAGPDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQV
IYRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAANVLNLVVLTAALSVYNSCVYCNSRMLYGLAQQGNAP
QALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFELLMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLG
YPLTNYFCLAFMAAILVVMFRTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR

Sequences:

>Translated_461_residues
MATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSY
FASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYWWPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKV
AAIIGMIGFGGYLLLSGHAGPDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQV
IYRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAANVLNLVVLTAALSVYNSCVYCNSRMLYGLAQQGNAP
QALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFELLMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLG
YPLTNYFCLAFMAAILVVMFRTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR
>Mature_460_residues
ATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSYF
ASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYWWPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKVA
AIIGMIGFGGYLLLSGHAGPDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQVI
YRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAANVLNLVVLTAALSVYNSCVYCNSRMLYGLAQQGNAPQ
ALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFELLMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLGY
PLTNYFCLAFMAAILVVMFRTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=68.6666666666667, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=62.8635346756152, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786602, Length=449, Percent_Identity=45.8797327394209, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=41.8918918918919, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=39.4335511982571, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=38.6574074074074, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI87081915, Length=452, Percent_Identity=35.6194690265487, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI87081708, Length=411, Percent_Identity=36.4963503649635, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=35.4166666666667, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87081869, Length=188, Percent_Identity=28.1914893617021, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082023, Length=191, Percent_Identity=27.2251308900524, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=445, Percent_Identity=35.2808988764045, Blast_Score=232, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=444, Percent_Identity=34.9099099099099, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=482, Percent_Identity=30.7053941908714, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322892, Length=409, Percent_Identity=32.7628361858191, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=420, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=34.0857787810384, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=32.4937027707809, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321053, Length=431, Percent_Identity=30.6264501160093, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=30.3703703703704, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=30.5288461538462, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=416, Percent_Identity=28.8461538461538, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319608, Length=445, Percent_Identity=28.7640449438202, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=415, Percent_Identity=30.6024096385542, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=29, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=408, Percent_Identity=30.6372549019608, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=428, Percent_Identity=28.7383177570093, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=30.8270676691729, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=487, Percent_Identity=25.8726899383984, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667468, Length=408, Percent_Identity=24.5098039215686, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221512776, Length=278, Percent_Identity=23.3812949640288, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24666159, Length=278, Percent_Identity=23.3812949640288, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49755; Mature: 49624

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFF
CCCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKVAAIIGMIGFGGYLLLSGHAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQV
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
IYRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAANVLNLVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLYGLAQQGNAPQALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFEL
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLGYPLTNYFCLAFMAAILVVMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
ATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFF
CCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKVAAIIGMIGFGGYLLLSGHAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQV
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
IYRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAANVLNLVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLYGLAQQGNAPQALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFEL
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLGYPLTNYFCLAFMAAILVVMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]