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The map label for this gene is tyrB-1 [H]

Identifier: 126446236

GI number: 126446236

Start: 1696374

End: 1697576

Strand: Reverse

Name: tyrB-1 [H]

Synonym: BMA10247_A1762

Alternate gene names: 126446236

Gene position: 1697576-1696374 (Counterclockwise)

Preceding gene: 126447392

Following gene: 126447827

Centisome position: 72.15

GC content: 68.08

Gene sequence:

>1203_bases
ATGTTTGAACACATCGATGCCTACCCCGGCGATCCGATTCTCACGCTGAACGAGAACTTTCAGCAGGACCCGCGCACGCG
CAAGGTCAATCTGAGCATCGGCATCTATTTCGACGACGACGGCCGGATTCCGGTGATGGGCGCCGTGCGCGAGGCCGAGG
CCATCGTGCAGCGCGAATCCGGTCCGAAGCCGTATCTGCCGATGACGGGGCTCGCCGCGTATCGCGACGCGGTGCAGGCG
GTGGTGTTCGGCGAGGGCAGCGATGCGCGCGCGGCCGGGCGCATCGCGACGGTGCAGACGCTCGGCGGCTCGGGCGCGCT
CAAGGTGGGCGCGGATTTCATCAAGCGCTACTTTCCGCACGCGCAGGTGTGGATCAGTGATCCGAGCTGGGAGAACCACC
GGTTCATCTTCGAGCGCGCGGGCTTCACGGTCAACACGTATCCGTACTACGACGAGGCGACGGGCGGCCTGAAATTCGAT
GCGATGCTGGCCGCGATCGACGCGCTGCCGCACAAGAGCGTCGTGCTGCTGCACGCGTGCTGCCACAACCCGACGGGCGT
CGATCTCGACGACGCGCAGTGGCTCAAGCTGATCGACGTGTTGCAGGCACGCGAGTTGCTGCCTTTCGTCGACATGGCGT
ACCAGGGCTTCGGCGCGGGTCTCGCGGCCGATGCGTTCGCGATTCGCGAACTCGCGCGCCGCGGGATGCCGGCGTTCGTC
GCGAACTCGTTCTCGAAGAACTTCTCGCTGTACGGCGAGCGCGTCGGCGCGCTGTCGGTGATCTGCGAGGACGCGGCGGC
CGCCGCGCGCGTGCTCGGCCAGCTCGCGGGCGCGGTGCGCTCGAACTACAGCAACCCGCCGACCTGCGGCGCGAAGATCG
TTGCGCAGGTGCTGACGACGCCCGCGCTGCGCGCGCAATGGGAGGAAGAGCTCGCGGCGATGTGCCGGCGCATCGCGAAG
ATGCGCAGCGCGATTCACGACGGCCTGCGCGCGCATGTGCCGGCCGAGGCGCTCACGCGCTACGTGAAGCAGCGCGGGAT
GTTCACGTACACGGGGCTGACCGAGGCGCAGGTCGAATGCCTGCGCGAGCAGCACGGCGTCTATGTCCTGCGCTCGGGCC
GGATGTGCGTCGCCGGGCTGAACGAGGCGAACGTCGGGATCGTCGCGGATGCGATCGGCGCGGTGATCGCGAGCGGCGTC
TGA

Upstream 100 bases:

>100_bases
GCGCTCGGCTACCGGTTCCGCCAGCGCGGCGCCGGCTATGCACTCGGCGGCGGCGTATCGGCCCGTTGATTCCGTTTTTT
CCTTCATTGTAGAAACCGCC

Downstream 100 bases:

>100_bases
CGCAGGCGCACGCGCCGAATGCGTCGGGCGCAGCGCGACGCCGGGCGCAGGCGCGTGCGGGATCGCGCCGGATGGTGCGT
GCGGCTGCGCGCCGGCGCGG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRESGPKPYLPMTGLAAYRDAVQA
VVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPHAQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPHKSVVLLHACCHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFV
ANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTTPALRAQWEEELAAMCRRIAK
MRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVECLREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV

Sequences:

>Translated_400_residues
MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRESGPKPYLPMTGLAAYRDAVQA
VVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPHAQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPHKSVVLLHACCHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFV
ANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTTPALRAQWEEELAAMCRRIAK
MRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVECLREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV
>Mature_400_residues
MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRESGPKPYLPMTGLAAYRDAVQA
VVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPHAQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPHKSVVLLHACCHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFV
ANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTTPALRAQWEEELAAMCRRIAK
MRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVECLREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=42.1717171717172, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI4504067, Length=388, Percent_Identity=40.7216494845361, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI117414139, Length=385, Percent_Identity=27.2727272727273, Blast_Score=181, Evalue=9e-46,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=58.4382871536524, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=42.6767676767677, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI71981858, Length=395, Percent_Identity=40.253164556962, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25147133, Length=395, Percent_Identity=40.5063291139241, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17569539, Length=399, Percent_Identity=40.1002506265664, Blast_Score=297, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17569537, Length=387, Percent_Identity=33.0749354005168, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17550384, Length=268, Percent_Identity=38.4328358208955, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147136, Length=211, Percent_Identity=38.8625592417062, Blast_Score=164, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=40.4938271604938, Blast_Score=315, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322743, Length=425, Percent_Identity=34.1176470588235, Blast_Score=246, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=43.0379746835443, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=43.0379746835443, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24580972, Length=396, Percent_Identity=40.4040404040404, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=40.4040404040404, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=40.8740359897172, Blast_Score=305, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43354; Mature: 43354

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRES
CCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHCC
GPKPYLPMTGLAAYRDAVQAVVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPH
CCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
AQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPHKSVVLLHAC
CEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEHHHH
CHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
ANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
PALRAQWEEELAAMCRRIAKMRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHHH
LREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV
HHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRES
CCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHCC
GPKPYLPMTGLAAYRDAVQAVVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPH
CCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
AQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPHKSVVLLHAC
CEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEHHHH
CHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
ANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
PALRAQWEEELAAMCRRIAKMRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHHH
LREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV
HHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]