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The map label for this gene is parE [H]

Identifier: 126455235

GI number: 126455235

Start: 1124759

End: 1126741

Strand: Direct

Name: parE [H]

Synonym: BURPS1106A_1145

Alternate gene names: 126455235

Gene position: 1124759-1126741 (Clockwise)

Preceding gene: 126452112

Following gene: 126454891

Centisome position: 28.2

GC content: 66.87

Gene sequence:

>1983_bases
ATGTCCACGAAAAAGCCTGCAGCGGCCTATAGCGAAGCATCGATCAAGGTGCTCAAGGGCCTCGAGCCCGTCAAGCAGCG
GCCCGGCATGTACACGCGCACCGAGAATCCGCTGCACATCATCCAGGAAGTGATCGACAACGCGTCCGACGAGGCGTTGG
GCGGCTTCGGCAAGCAGATCACGGTCACGCTGCACCCCGATCAATCGGTGTCCGTCGAGGACGACGGGCGCGGCATTCCG
TTCGGGCTGCATCCGGAGGAGAAGGTGCCCGTCGTCGAGATCGTGTTCACGCGGCTGCACGCCGGCGGCAAGTTCGACAA
GGCGAAGGGCGGCGCGTACACGTTCTCGGGCGGTCTGCACGGCGTGGGCGTGTCGGTGACGAATGCGCTCGCGACGCGCC
TCGACGTGACCGTCTGGCGCGACGGCAGGATCGCGCAGCTCGGCTTCGCCGACGGCGACGTCGTCAAGCCGCTCGCGACG
CAAGGCGCGGGCCGTGGCGAGAAGAAGTCCGGCACGCGGGTGACCGTGTGGCCGAATCCGAAATACTTCGATTCGCCGAA
TCTGCCGCTCGGCGAGCTGCAGCGGCTCCTGCGCTCGAAGGCGGTGCTGCTGCCGGGCGTCGAGGTCGTGCTCGTCAACG
AGAAGACGGGCGAGCGGCAGAGCTGGAAATACGACGACGGCCTGCGCGGCTACCTGCTCGACGAGATGAACGGCAGCGAG
CTGCTGATTCCGCTTTTCGAGGGCGAGCGCTTCGCCGATTCCCGCTCGGGCGACGACACGTTCGCCGAGGGCGAGGGCGC
GTCGTGGGTCGTCGCGTGGAGCGAGGAAGGCTCGCTCGTGCGCGAGTCGTACGTGAACCTGATTCCGACGCCCGCGGGCG
GCACGCACGAATCCGGCCTGCGCGACGGCCTCTATCAGGCGGTGAAGAGCTTCGTCGAGCTGCACAACCTGCAGCCGAAG
GGCGTGAAGCTGCTCGCGGAGGACGTGTTCGCGCGCGTGTCGTTCGTGCTCTCGGCGAAGGTGCTCGATCCGCAGTTCCA
GGGGCAGATCAAGGAGCGCCTGAACAGCCGCGACGCGGTGAAGCTCGTGTCGTCGTTCACGCGCCCGGCGCTCGAGCTGT
GGCTCAACCAGCACGTCGAGCACGGCAAGAAGCTCGCCGAGCTCGTGATCAAGCAGGCGCAGGCGCGCACGCGCGCGGGC
CAGAAGGTCGAGAAGAAGAAGAGTTCCGGCGTCGCGGTGCTGCCCGGCAAGCTGACCGACTGCGAGACCGAGGACATCGC
GCGCAACGAGCTGTTCCTCGTCGAGGGCGATTCGGCGGGCGGCTCCGCGAAGATGGGCCGCGACAAGGAATACCAGGCGA
TCCTGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAGACCGAGCGCGATCGCCTGTTCGCGAACAACGAGGTGCACGAC
ATCTCGGTGGCGATCGGCGTCGATCCGCACGGCCCGGACGACAGCGTCGACGTGTCGAACCTGCGTTACGGCAAGATCTG
CATCCTGTCGGATGCGGATGTCGACGGCGCGCACATTCAGGTGTTGCTGCTCACGCTGTTCTTCAAGCATTTCCCGCAAC
TGATCGAGCGCGGCCACGTGTTCGTCGCGCGGCCGCCGCTTTTCCGGGTCGACGCGCCCGCGCGCGGCAAGAAGCCGGCG
CAGAAGCTCTACGCGCTCGACGAAGGCGAGCTCGAGGCGATCCTCGACAAGCTGCGCAAGGACGGCGTGCGCGAATCGCA
ATGGACGATCAGCCGCTTCAAGGGCTTGGGCGAAATGAGCGCCGAGCAGCTGTGGGACACGACGATGAACCCCGACACCC
GCCGCCTGATGCCCGTCGCGCTCGGCGAGCTCGACTTCGAGGCGACGGTCGCGCGGATGACGATGCTGATGGGCAAGGGC
GAGGCCGCCGCGCGCCGCAACTGGCTCGAGGAAAAGGGCAACGAAGTCGAAGCGGATATCTGA

Upstream 100 bases:

>100_bases
TTGTTTCGACTCGGATTTTTATCGAATTCAACGTTTTGTCCACGATGTTATCCACACGCGCTGGGGATAACGTCAAGGTG
AATGACGAACCTGAGCTTCT

Downstream 100 bases:

>100_bases
GCGCGGCCGGGCGCGCGCCCGGCTTCGCATGCATCGCATATACGGACACGAAATCTAGATGGACGACAACACTCCCGATC
TTTTCGCCGAGCCGGCCGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIP
FGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGRIAQLGFADGDVVKPLAT
QGAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYDDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKG
EAAARRNWLEEKGNEVEADI

Sequences:

>Translated_660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIP
FGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGRIAQLGFADGDVVKPLAT
QGAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYDDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKG
EAAARRNWLEEKGNEVEADI
>Mature_659_residues
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIPF
GLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGRIAQLGFADGDVVKPLATQ
GAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYDDGLRGYLLDEMNGSEL
LIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPKG
VKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQ
KVEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHDI
SVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPAQ
KLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGE
AAARRNWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=646, Percent_Identity=23.9938080495356, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI19913406, Length=652, Percent_Identity=23.3128834355828, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1789408, Length=653, Percent_Identity=50.5359877488515, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=600, Percent_Identity=36.8333333333333, Blast_Score=355, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=651, Percent_Identity=23.8095238095238, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212645845, Length=610, Percent_Identity=23.9344262295082, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=213, Percent_Identity=29.1079812206573, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=644, Percent_Identity=25, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136538, Length=660, Percent_Identity=24.8484848484848, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72566; Mature: 72435

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQI
CCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEE
TVTLHPDQSVSVEDDGRGIPFGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
GVGVSVTNALATRLDVTVWRDGRIAQLGFADGDVVKPLATQGAGRGEKKSGTRVTVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYDDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKKKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGEAAARRNWLEEKGNEVEADI
HHHHHCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQI
CCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEE
TVTLHPDQSVSVEDDGRGIPFGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
GVGVSVTNALATRLDVTVWRDGRIAQLGFADGDVVKPLATQGAGRGEKKSGTRVTVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYDDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKKKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGEAAARRNWLEEKGNEVEADI
HHHHHCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]