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The map label for this gene is parC [H]

Identifier: 126454891

GI number: 126454891

Start: 1126800

End: 1129118

Strand: Direct

Name: parC [H]

Synonym: BURPS1106A_1146

Alternate gene names: 126454891

Gene position: 1126800-1129118 (Clockwise)

Preceding gene: 126455235

Following gene: 126452600

Centisome position: 28.25

GC content: 68.87

Gene sequence:

>2319_bases
ATGGACGACAACACTCCCGATCTTTTCGCCGAGCCGGCCGCGCCCGAGGGCGATTTCCTGACGCTCGGCCGCTACGCGGA
GCGCCAGTATCTCGACTACGCGGTGAGCGTGGTGAAGGGGCGCGCGCTGCCCGACGTGAGCGACGGGCAGAAGCCCGTGC
AGCGCCGGATTCTCTACGCGATGAACGAGATGGGCCTCGGCGACAACGCGAAGCCCGTGAAGTCCGCGCGCGTCGTCGGC
GACGTGCTCGGCAAGTACCACCCGCACGGCGACCAGTCCGCGTACGACGCGCTCGTGCGGCTCGCGCAGGATTTCTCGAT
GCGCTATCCGCTGATCGACGGCCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCGGCGGCGATGCGCTACACCGAGG
CGCGCCTCACGCCGATCGCGAAGCTGCTCCTCGACGAGATCGACGAGGGCACGGTCGAGTTCATGCCGAACTACGACGGC
TCGTTCGACGAGCCGAAGCTGTTGCCGGCCCGGCTGCCGTTCGTGCTGCTGAACGGCGCGTCGGGGATCGCGGTCGGTCT
CGCCACCGAGATCCCGTCGCACAACCTGCGCGAGGTCGCGGCCGCCGCGGTCGCGTTGATCCGCCATCCCGCGCTGCCGC
ACGCGGAGCTGATGCGGCTCGTGCCGGGGCCGGATTTCCCGGGCGGCGGCCAGATCATTTCGAGCGACGCGGAGATCTCC
GCCGCGTACGAAACCGGCCGCGGCAGCCTGAAGGTGCGCGCGCGCTGGAAGATCGAGGATCTCGCGCGCGGCCAGTGGCA
GCTCGTCGTCACCGAATTGCCGCCGAACACGTCGTGCCAGAAGGTGCTCGAGGAAATCGAGGAACTGACGAACCCGAAGC
TCAAGGCGGGCAAGAAGACGCTCACGCAGGAGCAGATCAACACGAAGAAGACGTTGCTCGATCTGCTCGACGCGGTGCGC
GACGAATCGGGCAAGGACGCGCCGGTGCGGCTCGTGTTCGAGCCGAAGACGCGTGCGATCGACCAGACCGAATTCGTCAA
TTCGCTGCTCGCGCACACGAGCCTCGAATCGAACGCTGCGCTCAATCTCGTGATGATCGGCGAGGACGGGCGGCCCGCGC
AGAAGGGGCTCGCGTCGATCCTCGGCGAGTGGGTGCGGTTCCGCCAGGCCACCGTCACGCGGCGCTGCCGCCACCGGCTC
GGCAAGGTGAACGATCGGATCCACATCCTCGAAGGGCGGATGATCGTCTTCCTGAACATCGACGAGGTGATCCGCATCAT
CCGCGAAGCGGATGAGCCGAAGGCCGCGCTCATCAGCGCGTTCGGCCTCACCGAGCGGCAGGCCGACGACATTCTCGAAA
TCCGGCTGCGCCAGTTGGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAGCTCGAAGAGCTGCGCGCGGAGAAGGCGAAG
CTCGAGGAACTGCTCGCGAACGAGAGCGCGATGAAGCGGCTGATGATCAAGGAGATCGAGGCCGATGCGAAGCAGTACGG
TGACGAGCGCCGCACGCTGATCCAGCAGGAGAAGCGCGCGACGTTCGAGGCGAAGGTCGTCGACGAGCCGGTGACGGTGG
TCGTATCGCAGAAGGGCTGGGTGCGCGCGCTGAAGGGCCACGGGCTCGATCCGGCGAGCTTCTCGTTCAAGGCGGGCGAC
GGCCTGTACGCGGCGTTCCAGTGCCGCACGCCGGACACGCTGATCGCGTGGGGCAGCACGGGCCGCGTGTATTCGGTGGC
CGTCCAGGTGCTGCCCGGCGGGCGCGGCGACGGTGTGCCCGTCACGTCGCTGATCGAGCTCGAATCGGGCTCGCACCTGC
TGCACTACTACGCGGCCCCGGCCGAGCAGCCGCTGTTGCTCGCGTCGAGCAACGGCTTCGGCTTCGTCGCGAAGGTCGGC
GACATGGTGAGCCGCGTGAAGGCGGGCAAATCGTTCATGACGATCGACGACGGGGCGGCGCCGCTCGCGCCGATGCCGGT
GCTGCCGGATGCGTCGCAGGTCGCGTGCCTGTCGAGCGGCGGGCGCCTGCTCGTGTTCGGCATGGACGAGATGAAGACGC
TCTCGGGCGGCGGGCGCGGCGTGATCCTGATGGCGCTCGACGCGAAGGAGACGCTCGTGCAGGCGCTCGCGATCGACGCG
GCGGGCGTCGTGCTCACGGGCACGGGCCGCGGCGGCAAGGCGCAGGAGGAGGCGCTCGCGGGGCGCGCGCTCGAGCCGCA
CGTCGGCAAGCGGGCGCGCAAGGGGCGTGCGCCGGATACCCGGCTGAAGGTCAACGGGCTGAGGCCGGTGCTCGGCTGA

Upstream 100 bases:

>100_bases
TGGCTCGAGGAAAAGGGCAACGAAGTCGAAGCGGATATCTGAGCGCGGCCGGGCGCGCGCCCGGCTTCGCATGCATCGCA
TATACGGACACGAAATCTAG

Downstream 100 bases:

>100_bases
GCCGCACCGGGCACGGCTGACGGGGCTCGAGCCGGGCGGCCCGACGGGGCGGCTCGGCCGGACCGGCGCCGGCGCGCGCG
GTCTTCGGCCTTTGCTTCGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 772; Mature: 772

Protein sequence:

>772_residues
MDDNTPDLFAEPAAPEGDFLTLGRYAERQYLDYAVSVVKGRALPDVSDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDEGTVEFMPNYDG
SFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRHPALPHAELMRLVPGPDFPGGGQIISSDAEIS
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKAGKKTLTQEQINTKKTLLDLLDAVR
DESGKDAPVRLVFEPKTRAIDQTEFVNSLLAHTSLESNAALNLVMIGEDGRPAQKGLASILGEWVRFRQATVTRRCRHRL
GKVNDRIHILEGRMIVFLNIDEVIRIIREADEPKAALISAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEKAK
LEELLANESAMKRLMIKEIEADAKQYGDERRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
GLYAAFQCRTPDTLIAWGSTGRVYSVAVQVLPGGRGDGVPVTSLIELESGSHLLHYYAAPAEQPLLLASSNGFGFVAKVG
DMVSRVKAGKSFMTIDDGAAPLAPMPVLPDASQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDAKETLVQALAIDA
AGVVLTGTGRGGKAQEEALAGRALEPHVGKRARKGRAPDTRLKVNGLRPVLG

Sequences:

>Translated_772_residues
MDDNTPDLFAEPAAPEGDFLTLGRYAERQYLDYAVSVVKGRALPDVSDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDEGTVEFMPNYDG
SFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRHPALPHAELMRLVPGPDFPGGGQIISSDAEIS
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKAGKKTLTQEQINTKKTLLDLLDAVR
DESGKDAPVRLVFEPKTRAIDQTEFVNSLLAHTSLESNAALNLVMIGEDGRPAQKGLASILGEWVRFRQATVTRRCRHRL
GKVNDRIHILEGRMIVFLNIDEVIRIIREADEPKAALISAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEKAK
LEELLANESAMKRLMIKEIEADAKQYGDERRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
GLYAAFQCRTPDTLIAWGSTGRVYSVAVQVLPGGRGDGVPVTSLIELESGSHLLHYYAAPAEQPLLLASSNGFGFVAKVG
DMVSRVKAGKSFMTIDDGAAPLAPMPVLPDASQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDAKETLVQALAIDA
AGVVLTGTGRGGKAQEEALAGRALEPHVGKRARKGRAPDTRLKVNGLRPVLG
>Mature_772_residues
MDDNTPDLFAEPAAPEGDFLTLGRYAERQYLDYAVSVVKGRALPDVSDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDEGTVEFMPNYDG
SFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRHPALPHAELMRLVPGPDFPGGGQIISSDAEIS
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKAGKKTLTQEQINTKKTLLDLLDAVR
DESGKDAPVRLVFEPKTRAIDQTEFVNSLLAHTSLESNAALNLVMIGEDGRPAQKGLASILGEWVRFRQATVTRRCRHRL
GKVNDRIHILEGRMIVFLNIDEVIRIIREADEPKAALISAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEKAK
LEELLANESAMKRLMIKEIEADAKQYGDERRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
GLYAAFQCRTPDTLIAWGSTGRVYSVAVQVLPGGRGDGVPVTSLIELESGSHLLHYYAAPAEQPLLLASSNGFGFVAKVG
DMVSRVKAGKSFMTIDDGAAPLAPMPVLPDASQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDAKETLVQALAIDA
AGVVLTGTGRGGKAQEEALAGRALEPHVGKRARKGRAPDTRLKVNGLRPVLG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=184, Percent_Identity=33.1521739130435, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI19913406, Length=188, Percent_Identity=31.3829787234043, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789396, Length=755, Percent_Identity=46.0927152317881, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1788562, Length=756, Percent_Identity=35.8465608465608, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=195, Percent_Identity=32.3076923076923, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI212645845, Length=407, Percent_Identity=24.5700245700246, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=199, Percent_Identity=31.6582914572864, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115534553, Length=191, Percent_Identity=29.3193717277487, Blast_Score=80, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=31.4516129032258, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136538, Length=234, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83832; Mature: 83832

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTPDLFAEPAAPEGDFLTLGRYAERQYLDYAVSVVKGRALPDVSDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MNEMGLGDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGS
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDEGTVEFMPNYDGSFDEPKLLPARLPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRHPALPHAELMRLVPGPDFPGGGQIISSDAEIS
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKAGKKT
EEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHCCHHH
LTQEQINTKKTLLDLLDAVRDESGKDAPVRLVFEPKTRAIDQTEFVNSLLAHTSLESNAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMIGEDGRPAQKGLASILGEWVRFRQATVTRRCRHRLGKVNDRIHILEGRMIVFLNI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEH
DEVIRIIREADEPKAALISAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEKAK
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDERRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPASFSFKAGDGLYAAFQCRTPDTLIAWGSTGRVYSVAVQVLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCCEEEEEEEEECCCCCCCCC
VTSLIELESGSHLLHYYAAPAEQPLLLASSNGFGFVAKVGDMVSRVKAGKSFMTIDDGAA
EEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
PLAPMPVLPDASQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDAKETLVQALAIDA
CCCCCCCCCCCCHHHHCCCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCC
AGVVLTGTGRGGKAQEEALAGRALEPHVGKRARKGRAPDTRLKVNGLRPVLG
CCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MDDNTPDLFAEPAAPEGDFLTLGRYAERQYLDYAVSVVKGRALPDVSDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MNEMGLGDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGS
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDEGTVEFMPNYDGSFDEPKLLPARLPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRHPALPHAELMRLVPGPDFPGGGQIISSDAEIS
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKAGKKT
EEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHCCHHH
LTQEQINTKKTLLDLLDAVRDESGKDAPVRLVFEPKTRAIDQTEFVNSLLAHTSLESNAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMIGEDGRPAQKGLASILGEWVRFRQATVTRRCRHRLGKVNDRIHILEGRMIVFLNI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEH
DEVIRIIREADEPKAALISAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEKAK
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDERRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPASFSFKAGDGLYAAFQCRTPDTLIAWGSTGRVYSVAVQVLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCCEEEEEEEEECCCCCCCCC
VTSLIELESGSHLLHYYAAPAEQPLLLASSNGFGFVAKVGDMVSRVKAGKSFMTIDDGAA
EEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
PLAPMPVLPDASQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDAKETLVQALAIDA
CCCCCCCCCCCCHHHHCCCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCC
AGVVLTGTGRGGKAQEEALAGRALEPHVGKRARKGRAPDTRLKVNGLRPVLG
CCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]