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The map label for this gene is kefB [H]

Identifier: 126454989

GI number: 126454989

Start: 570612

End: 572621

Strand: Direct

Name: kefB [H]

Synonym: BURPS1106A_0603

Alternate gene names: 126454989

Gene position: 570612-572621 (Clockwise)

Preceding gene: 126454675

Following gene: 126455354

Centisome position: 14.31

GC content: 69.2

Gene sequence:

>2010_bases
GTGATTTCCCCGCTCGAAATGACGCTTCTGCTGCTGCTTGCCTCGGTGGTGGGCGTCGTCGTGTTCCGTTCGCTGAACCT
GCCGCCGATGCTCGGCTATCTGACGGTCGGCATCCTGGTCGGTCCGCATGCGCTCGGCTTCGCGGCCGACCTCGAGCGCG
CCGAGCATCTCGCCGAGTTCGGCGTCGTGTTCCTGATGTTCTCGATCGGCCTCGAGTTCTCGTTGTCGAAGCTGCGCGCG
ATGCGCCGGCTCGTGTTCGGGCTCGGGCTCGCGCAGGTGCTCGGCACGATCGCGATCGCGCTCGTGCTGGGCGCGCTCTT
CGAGCGCTGGATGCACATCACGTGGGAAGGCAGCGTCGCGCTCGGCGGCGCGCTCGCGATGTCGTCCACCGCGATCGTCT
CGAAAATGCTCGCCGAGCGGCTCGAGATCGAGACCGAGCACGGCCGCAACATCTTCGGCGTGCTGCTGTTCCAGGATCTC
GCCGTCGTGCCGCTGCTCATCGTGATCGCCGCGTTCGGCGGCGAATCGTCGAAGGATCTCGCGATGTCGCTCGGGTTCGC
GGCGGTGAAGATCGTCGTCGCGCTCGCGCTGCTGCTGATCGTCGGCCAGCGCTTCATGACGCGCTGGCTGAACGTCGTCG
CGCGGCGGCGCTCGCAGGAGCTGTTCGTGCTGAACCTGCTGCTCGTCACGCTCGGCGCCGCGTTCATCACCGACCGCTTC
GGCCTGTCGCTCGCGCTCGGCGCGTTCATCGCCGGGATGCTGATCTCCGAGACGCCGTATCGGCATCAGGTGGAAGAGGA
CATCAAGCCGTTTCGCGACGTGCTGCTTGGCCTGTTCTTCGTGACGACCGGGATGCTGCTCGATCCGAGCGTGATCTGGC
GGCATCCGTTGCTCGTGCTCGCGTTCTTCGTGGGCCAGGTGCTGCTCAAGAGCGTGATGATCACGGGGCTCGCGCGCGCG
TTCGGCGCGACGCCCGGCGTCGCGATGCGCACGGGGCTCGGGCTCGCGCAGGCGGGCGAGTTCGGCTTCGTGCTCCTGAA
CCTGATTCTCGACCGGCATCTCGTCGACGCGACGCTGTTGCAGTCGATCCTCGCTTCGATGCTGCTGTCGATGCTCGCCG
CGCCGTTCCTGATCCAGAACGCGGATCGCATCGTGATGCGGCTGTCCGCCGCGGAATGGATGCAGCAGTCGCTGCAGATG
ACGCGCATCGCGACGCAGAGCATCAAGCAGAAGGGCCACGTGATCATCTGCGGCTACGGCCGCGCCGGGCAGAACCTCGC
GCGGATGCTCGAGCAGGAGGGGATCGCGTACGTCGCGCTCGATCTCGATCCGGACCGCGTGGCGGCCGCGGCGGCGGCGG
GCGAATCGGTCGTGTTCGGCGACGCCGCGCGCCGCGAATCGCTGCTCGCGGCGGGCATCCATCGCGCGGCGGCGGTGGCC
GTCACCTACGCGAACACGCCGTCCGCGTTGCGCGTGCTGCACAACGTGCACGAGCTCGAGCCGACGCTGCCCGCGATCGT
GCGCACCGTCGACGACGCCGATCTCGAGAAGCTGCTCGCCGCGGGCGCGACCGAGGTGATTCCGGAGATCGTCGAGGGCA
GCCTGATGCTCGCGTCGCACACGCTCGTGCTGATGGGCGTGCCGATGCGGCGCGTCGTGCGGCGCGTCGAGGAGATGCGC
GACGCGCGCTACAGCCTGCTGCGCGGCTACTTCCACGGCGCCGACGACGCGGACGACGACGACCACGAGCAGGTGCGGCT
ACAATCGGTGCCCGTCGACGCGCGCGCGGACGCGGTCGGCCGCTCGCTCTCCGAGCTGGGGCTGTTCGCGCTCGGCCTGG
AGGTGACGGCGATTCGCCGGCATGGGATTCGCGGCGTCGAACCCGACCCCGAGACGAAGCTGCGCGCGAGCGACATCGTC
GTGCTGCGCGGGTTGCCCGAGGCGCTCGCCCAGGCCGAGGAGCGGCTGTCGCGGCATCGGCGCGAAGGCGGATCGGCCGC
GGTGGCGTGA

Upstream 100 bases:

>100_bases
CGCCGCGCCGGGCCCCTTGCGCCCACCTTTTCCGAGTAGTCTCCCGGCCCACCCCGGCGTCCGTTGCGCGGCGCCGTCGA
CGAACGAGGACGCTTCGCCC

Downstream 100 bases:

>100_bases
CGCCGGGCGGCCGCCGCTTGTTCAGTTGTCGAGCGATCGACGAACGGCGCGAGATTGCAGCGCCGTTTTTTTTTGGAGAG
TTTCATGATGTCCACGTCGG

Product: monovalent cation:proton antiporter-2 (CPA2) family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHALGFAADLERAEHLAEFGVVFLMFSIGLEFSLSKLRA
MRRLVFGLGLAQVLGTIAIALVLGALFERWMHITWEGSVALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGGESSKDLAMSLGFAAVKIVVALALLLIVGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPYRHQVEEDIKPFRDVLLGLFFVTTGMLLDPSVIWRHPLLVLAFFVGQVLLKSVMITGLARA
FGATPGVAMRTGLGLAQAGEFGFVLLNLILDRHLVDATLLQSILASMLLSMLAAPFLIQNADRIVMRLSAAEWMQQSLQM
TRIATQSIKQKGHVIICGYGRAGQNLARMLEQEGIAYVALDLDPDRVAAAAAAGESVVFGDAARRESLLAAGIHRAAAVA
VTYANTPSALRVLHNVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLMGVPMRRVVRRVEEMR
DARYSLLRGYFHGADDADDDDHEQVRLQSVPVDARADAVGRSLSELGLFALGLEVTAIRRHGIRGVEPDPETKLRASDIV
VLRGLPEALAQAEERLSRHRREGGSAAVA

Sequences:

>Translated_669_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHALGFAADLERAEHLAEFGVVFLMFSIGLEFSLSKLRA
MRRLVFGLGLAQVLGTIAIALVLGALFERWMHITWEGSVALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGGESSKDLAMSLGFAAVKIVVALALLLIVGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPYRHQVEEDIKPFRDVLLGLFFVTTGMLLDPSVIWRHPLLVLAFFVGQVLLKSVMITGLARA
FGATPGVAMRTGLGLAQAGEFGFVLLNLILDRHLVDATLLQSILASMLLSMLAAPFLIQNADRIVMRLSAAEWMQQSLQM
TRIATQSIKQKGHVIICGYGRAGQNLARMLEQEGIAYVALDLDPDRVAAAAAAGESVVFGDAARRESLLAAGIHRAAAVA
VTYANTPSALRVLHNVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLMGVPMRRVVRRVEEMR
DARYSLLRGYFHGADDADDDDHEQVRLQSVPVDARADAVGRSLSELGLFALGLEVTAIRRHGIRGVEPDPETKLRASDIV
VLRGLPEALAQAEERLSRHRREGGSAAVA
>Mature_669_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHALGFAADLERAEHLAEFGVVFLMFSIGLEFSLSKLRA
MRRLVFGLGLAQVLGTIAIALVLGALFERWMHITWEGSVALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGGESSKDLAMSLGFAAVKIVVALALLLIVGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPYRHQVEEDIKPFRDVLLGLFFVTTGMLLDPSVIWRHPLLVLAFFVGQVLLKSVMITGLARA
FGATPGVAMRTGLGLAQAGEFGFVLLNLILDRHLVDATLLQSILASMLLSMLAAPFLIQNADRIVMRLSAAEWMQQSLQM
TRIATQSIKQKGHVIICGYGRAGQNLARMLEQEGIAYVALDLDPDRVAAAAAAGESVVFGDAARRESLLAAGIHRAAAVA
VTYANTPSALRVLHNVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLMGVPMRRVVRRVEEMR
DARYSLLRGYFHGADDADDDDHEQVRLQSVPVDARADAVGRSLSELGLFALGLEVTAIRRHGIRGVEPDPETKLRASDIV
VLRGLPEALAQAEERLSRHRREGGSAAVA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=344, Percent_Identity=28.4883720930233, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1789749, Length=562, Percent_Identity=33.4519572953737, Blast_Score=249, Evalue=5e-67,
Organism=Escherichia coli, GI1786232, Length=622, Percent_Identity=31.0289389067524, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1786685, Length=534, Percent_Identity=30.5243445692884, Blast_Score=206, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 72296; Mature: 72296

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHALGFAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLSKLRAMRRLVFGLGLAQVLGTIAIALVLGALFERWMHITWEGSVA
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGGESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AMSLGFAAVKIVVALALLLIVGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPYRHQVEEDIKPFRDVLLGLFFVTTGMLLDPSVIWRHPLLVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AFFVGQVLLKSVMITGLARAFGATPGVAMRTGLGLAQAGEFGFVLLNLILDRHLVDATLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
QSILASMLLSMLAAPFLIQNADRIVMRLSAAEWMQQSLQMTRIATQSIKQKGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGIAYVALDLDPDRVAAAAAAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEE
VTYANTPSALRVLHNVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
TLVLMGVPMRRVVRRVEEMRDARYSLLRGYFHGADDADDDDHEQVRLQSVPVDARADAVG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCHHHHHHH
RSLSELGLFALGLEVTAIRRHGIRGVEPDPETKLRASDIVVLRGLPEALAQAEERLSRHR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
REGGSAAVA
HCCCCCCCC
>Mature Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHALGFAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLSKLRAMRRLVFGLGLAQVLGTIAIALVLGALFERWMHITWEGSVA
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGGESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AMSLGFAAVKIVVALALLLIVGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPYRHQVEEDIKPFRDVLLGLFFVTTGMLLDPSVIWRHPLLVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AFFVGQVLLKSVMITGLARAFGATPGVAMRTGLGLAQAGEFGFVLLNLILDRHLVDATLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
QSILASMLLSMLAAPFLIQNADRIVMRLSAAEWMQQSLQMTRIATQSIKQKGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGIAYVALDLDPDRVAAAAAAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEE
VTYANTPSALRVLHNVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
TLVLMGVPMRRVVRRVEEMRDARYSLLRGYFHGADDADDDDHEQVRLQSVPVDARADAVG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCHHHHHHH
RSLSELGLFALGLEVTAIRRHGIRGVEPDPETKLRASDIVVLRGLPEALAQAEERLSRHR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
REGGSAAVA
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA