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The map label for this gene is mutY [H]

Identifier: 126454675

GI number: 126454675

Start: 559728

End: 560834

Strand: Direct

Name: mutY [H]

Synonym: BURPS1106A_0591

Alternate gene names: 126454675

Gene position: 559728-560834 (Clockwise)

Preceding gene: 126453315

Following gene: 126454989

Centisome position: 14.03

GC content: 72.9

Gene sequence:

>1107_bases
TTGAAACCGCCCCGCATTCCACCCGCGCCGCCCGTCATCACGCCGCTTCATTCGGCCTTCGCGCCGACGCTGATCGCGTG
GCAGCGCAAGCACGGCCGCCACGACCTGCCGTGGCAGAACACCCGCGATCCGTACCGGATCTGGCTGTCGGAGATCATGT
TGCAGCAGACGCAGGTGTCGACCGTCGTGCCGTATTACGTGCGCTTTCTCGAGCGCTATCCGGATGTGGCTGCGCTCGCG
GCCGCGCCGATCGACGACGTGATGGCGCTGTGGGCCGGGCTCGGCTACTACTCGCGCGCGCGCAATCTGCACCGCTGCGC
GCAGGCGGTCGTCGAGCGGCACGGCGGCGCGTTTCCGGCGTCGCCCGAGGCGCTCGCCGAGCTGCCGGGCATCGGCCGCT
CGACGGCCGCGGCGATCGCATCGTTCGCGTTCGGCGCGCGCGCGACGATTCTCGACGGCAACGTGAAGCGGGTGCTCGCG
CGCGTGTTCGGCGTCGAAGGCTTCCCGGGCGACAAGCGCATCGAGAACGAGATGTGGGCGCTCGCCGAGGCGCTTTTGCC
CGACGCGGCCGAGCCAACCGACGTCACCGCGTACACGCAGGGCCTGATGGATCTCGGCGCGACGCTCTGCGTGCGCGGCA
AGCCCGAATGCGGGCGCTGCCCGTTCGCGGGCGATTGCGTCGCGCAACGCAGCGGCCGGCAGCGCGAGCTGCCCGCCGCG
CGCCCGAAGAAGGCGGTGCCCACGCGCCGCACGTGGATGCTCGTGCTGCGCGACGGCGACGCGGTGCTGCTGCAGCGGCG
TCCGCCCGCCGGCATCTGGGGCGGCTTATGGAGCCTGCCCGAGGCGGACGGCGACGCGGCGCTCGCGCGGCGCGCGCGCG
AATTCGGCGGCGCGGCGCTCGTGCCGCTCGCGCCGCTCACGCATACGTTTACGCACTTCAGGCTCGAGATCGAGCCGCGG
CTCGCCGAGCTCGACGGCGCGGCCGGCGGCGCGCCGCCGGCGGCCGACGACGAGACCGCCTGGGTCTTGCTCGACAGGCT
CGACGCGTACGGCGTGCCCGCGCCCGTGCGCAAGTTGCTCGACGGTTTGAGCGGACCGCTGCTGTAA

Upstream 100 bases:

>100_bases
CGCGCGGGCGAGCCGTGCCGCGTCTGCGGCGCGCCGATCCGCCAGATCGTCCAGGGGCAGCGATCCACCTATTTCTGTCC
GAATTGTCAGCGTTAAGAAC

Downstream 100 bases:

>100_bases
GGGCGGCAGGCGCGGTGCCGACGCGGAACACGGATGGCGCCGCGTTCCGCCGCCCGCCGCCCGCAGCCCGGCGCGCGGTG
AATGCGCGTGGGGCACGGCG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKPPRIPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYVRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPASPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLA
RVFGVEGFPGDKRIENEMWALAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGDCVAQRSGRQRELPAA
RPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAALVPLAPLTHTFTHFRLEIEPR
LAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLLDGLSGPLL

Sequences:

>Translated_368_residues
MKPPRIPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYVRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPASPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLA
RVFGVEGFPGDKRIENEMWALAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGDCVAQRSGRQRELPAA
RPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAALVPLAPLTHTFTHFRLEIEPR
LAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLLDGLSGPLL
>Mature_368_residues
MKPPRIPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYVRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPASPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLA
RVFGVEGFPGDKRIENEMWALAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGDCVAQRSGRQRELPAA
RPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAALVPLAPLTHTFTHFRLEIEPR
LAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLLDGLSGPLL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=415, Percent_Identity=32.5301204819277, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI6912520, Length=415, Percent_Identity=32.5301204819277, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI190358497, Length=415, Percent_Identity=32.5301204819277, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI115298654, Length=415, Percent_Identity=32.5301204819277, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI115298652, Length=415, Percent_Identity=32.5301204819277, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI115298650, Length=415, Percent_Identity=32.7710843373494, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1789331, Length=349, Percent_Identity=44.6991404011461, Blast_Score=317, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39895; Mature: 39895

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPRIPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVVPYYVRFLERYPDVAALAAAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPA
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLARVFGVEGFPGDKRIENEMWA
CHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGDCVAQRSGRQRELPAA
HHHHHCCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCC
RPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAAL
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCEEE
VPLAPLTHTFTHFRLEIEPRLAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLL
EECCHHHHHHEEEEEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
DGLSGPLL
HHHCCCCC
>Mature Secondary Structure
MKPPRIPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVVPYYVRFLERYPDVAALAAAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPA
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLARVFGVEGFPGDKRIENEMWA
CHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGDCVAQRSGRQRELPAA
HHHHHCCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCC
RPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAAL
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCEEE
VPLAPLTHTFTHFRLEIEPRLAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLL
EECCHHHHHHEEEEEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
DGLSGPLL
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]