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The map label for this gene is apt [H]

Identifier: 126455354

GI number: 126455354

Start: 572676

End: 573269

Strand: Direct

Name: apt [H]

Synonym: BURPS1106A_0604

Alternate gene names: 126455354

Gene position: 572676-573269 (Clockwise)

Preceding gene: 126454989

Following gene: 126452184

Centisome position: 14.36

GC content: 66.33

Gene sequence:

>594_bases
TTGCAGCGCCGTTTTTTTTTGGAGAGTTTCATGATGTCCACGTCGGACGCGCCGCTCGATCCCGTCGAGTTCATTCACAG
CCGCATCCGCACGGTGCCGGACTGGCCGCAGCCCGGCGTGATGTTTCGCGACATCACGCCGCTGCTGCAAAGCGCGAAGG
CGTTGCGCGTGCTCGTCGACCTGTTCGTCGAGCGCTATGTCGACGCGAAGCTCGACTACATCGCGGGCCTCGATGCGCGC
GGCTTCATCATCGCGCCGATCGTCGCGTACGAGCTGTCCGTCGGCTTCGTGCCGATCCGCAAGGTCGGCAAGCTGCCGTA
CGCGACGCAGCGCGAATCGTATGCGCTCGAGTACGGCACCGCGACCGTCGAGATTCACGAGGACGCGTGCAAGCCGGGCG
ATCGCGTCGTGATCGTCGACGATCTGATCGCGACGGGCGGCACGATGATGGCGGGCAAGAACCTGCTCGAGCGGCTGGGC
GCCGTCGTCGTCGAAGGCGCGGCGATCGTCGATCTGCCGGATCTCGGCGGCTCGGCGCTGCTGCGCGGAGCCGGCCTGCC
GCTCTACACGGTCACCGAATTCCCCGGGCACTGA

Upstream 100 bases:

>100_bases
GCTGTCGCGGCATCGGCGCGAAGGCGGATCGGCCGCGGTGGCGTGACGCCGGGCGGCCGCCGCTTGTTCAGTTGTCGAGC
GATCGACGAACGGCGCGAGA

Downstream 100 bases:

>100_bases
GCGCGCCGACCGCGCGCCGGCCGCCGTGCCCGGTTTCGTGCCGCGCCTGCACCGGGCGCGGTCCATTCAGCCACCGATTC
AAGCGAGCCCACGATGCCGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MQRRFFLESFMMSTSDAPLDPVEFIHSRIRTVPDWPQPGVMFRDITPLLQSAKALRVLVDLFVERYVDAKLDYIAGLDAR
GFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLG
AVVVEGAAIVDLPDLGGSALLRGAGLPLYTVTEFPGH

Sequences:

>Translated_197_residues
MQRRFFLESFMMSTSDAPLDPVEFIHSRIRTVPDWPQPGVMFRDITPLLQSAKALRVLVDLFVERYVDAKLDYIAGLDAR
GFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLG
AVVVEGAAIVDLPDLGGSALLRGAGLPLYTVTEFPGH
>Mature_197_residues
MQRRFFLESFMMSTSDAPLDPVEFIHSRIRTVPDWPQPGVMFRDITPLLQSAKALRVLVDLFVERYVDAKLDYIAGLDAR
GFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLG
AVVVEGAAIVDLPDLGGSALLRGAGLPLYTVTEFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=47.4576271186441, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=51.1627906976744, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=49.4318181818182, Blast_Score=180, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=44.6540880503145, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=37.7245508982036, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=40.8045977011494, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 21551; Mature: 21551

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRRFFLESFMMSTSDAPLDPVEFIHSRIRTVPDWPQPGVMFRDITPLLQSAKALRVLVD
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFVERYVDAKLDYIAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGT
HHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECC
ATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLGAVVVEGAAIVDLPDLGGSAL
EEEEECCCCCCCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
LRGAGLPLYTVTEFPGH
HHCCCCCEEEECCCCCC
>Mature Secondary Structure
MQRRFFLESFMMSTSDAPLDPVEFIHSRIRTVPDWPQPGVMFRDITPLLQSAKALRVLVD
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFVERYVDAKLDYIAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYATQRESYALEYGT
HHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECC
ATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLERLGAVVVEGAAIVDLPDLGGSAL
EEEEECCCCCCCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
LRGAGLPLYTVTEFPGH
HHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA