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The map label for this gene is ndk [H]

Identifier: 126452672

GI number: 126452672

Start: 2220596

End: 2221021

Strand: Reverse

Name: ndk [H]

Synonym: BURPS1106A_2231

Alternate gene names: 126452672

Gene position: 2221021-2220596 (Counterclockwise)

Preceding gene: 126455291

Following gene: 126453816

Centisome position: 55.69

GC content: 62.68

Gene sequence:

>426_bases
ATGGCACTCGAGCGCACCCTGTCGATCATCAAGCCGGATGCGGTGGCGAAGAACGTGATCGGCCAGATCTACAGCCGTTT
CGAAAACGCCGGCCTGAAGATCGTGGCGGCGCGCATGGCGCACCTGTCGCGCGCCGATGCGGAGAAGTTCTACGCCGTGC
ACGCCGAGCGTCCGTTCTTCAAGGATCTCGTCGATTTCATGATCTCGGGCCCGGTGATGATCCAGGTGCTGGAAGGCGAG
GACGCGATTCTGAAGAACCGCGACCTGATGGGCGCGACGGATCCGAAGAAGGCGGAAAAGGGCACGATCCGTGCCGACTT
CGCGGACAGCATCGACGCGAACGCCGTGCACGGCTCGGACGCACCGGAAACGGCGCGCGCCGAAGTCGCGTTCTTCTTCC
CGGAAATGAACGTCTACTCGCGCTAA

Upstream 100 bases:

>100_bases
CCTTTCGATCGTGTAAGGGTTCAATCGCAATGATACACGGGAACGTGTTACAATAGCGGATTCATTTGGAACTGTAACCT
CTTAATTTTTTGGAGTTTTT

Downstream 100 bases:

>100_bases
GCGAGTCGGGGTCCGGCGCGTTCGGCGGCAAGGCAGGCATCATGGCGGGCGAAACCATCGTCAATCTACTCGACCTCGAC
GCCGAGGGCCTCGTCGCGTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGE
DAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR

Sequences:

>Translated_141_residues
MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGE
DAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR
>Mature_140_residues
ALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGED
AILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=43.9393939393939, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392203, Length=134, Percent_Identity=39.5522388059701, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=39.5522388059701, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=39.5522388059701, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=39.5522388059701, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=39.5522388059701, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=38.8059701492537, Blast_Score=109, Evalue=7e-25,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=38.8059701492537, Blast_Score=109, Evalue=8e-25,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=36.1538461538462, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=36.6906474820144, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=36.6906474820144, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=37.1428571428571, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=35.2517985611511, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=33.5714285714286, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=33.0935251798561, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=57.4468085106383, Blast_Score=173, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=41.0071942446043, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=40.7692307692308, Blast_Score=117, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=43.9393939393939, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=31.8840579710145, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=31.6176470588235, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15562; Mature: 15431

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFF
CCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHEEEECCCCCHH
KDLVDFMISGPVMIQVLEGEDAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETARAEVAFFFPEMNVYSR
CCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
ALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFF
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHEEEECCCCCHH
KDLVDFMISGPVMIQVLEGEDAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETARAEVAFFFPEMNVYSR
CCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA