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The map label for this gene is fadA [H]

Identifier: 126451726

GI number: 126451726

Start: 2305416

End: 2306594

Strand: Reverse

Name: fadA [H]

Synonym: BURPS1106A_2331

Alternate gene names: 126451726

Gene position: 2306594-2305416 (Counterclockwise)

Preceding gene: 126454510

Following gene: 126452407

Centisome position: 57.83

GC content: 70.91

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCGACCGCCCGCACCGGGCTCGCGAAATCCTGGCGCGGCGCGTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCACGTGGTCGCGGCGGCCGTCGAGCGCGCGAAGCTCGATCCCGCGCGCGTCGAGGACGTGCTGA
TCGGCTGCGCGAACCCGGAAGGCGCGACGGGCGCGAACATCGCGCGGCAGATCGCGCTGCGCGCGGGGCTGCCCGTCGGC
GTGCCGGGGATGACCGTCAACCGCTTCTGCTCGTCGGGATTGCAGACGATCGCGCTCGCCGCGCAGCGCGTGATCGCGGG
CGAGGGCGACGTGTTCGTCGCGGGCGGCGTCGAATCGATCTCGTGCGTGCAGAACGAGATGAACCGCCACATGCTGCGCG
AGGGCTGGCTCGACGCGCACAAGCCGGAGATCTACTGGACGATGCTGCAGACGGCCGAGAACGTCGCGAAGCGTTACGGC
ATCTCGAAGGCGCGCCAGGACGAGTACGGCGTGAATTCGCAGCTGCGCGCGGCCGCCGCGCAGGCGGCGGGGCGCTTTAA
CGCCGAGATCGTGCCGATCACCGTGCGCGCGGGCGTCGCCGACAAGGCGACGGGCCGCCTCTACACGAAGGAGGTGACGC
TCGCCGCCGACGAGGGCATTCGGCCCGACACGACGCTCGAGGGCGTCGCGAAGATCCGCGCGGCGCTGCCGGGCGGCGTG
ATCACCGCGGGCAACGCGAGCCAGTTCTCGGACGGCGCGGCCGCGTGCGTCGTGATGAACGCGAAGGTGGCCGAGCGCGA
GGGCCTCGCGCCGCTCGGCATTTTCCGCGGCTTCGCGGTGGCCGGCTGCGAGCCGGACGAGATGGGCATCGGGCCCGTCT
ACGCGGTGCCGAAGCTGCTGAAGCAGGCGGGGCTCAAGGTGTCCGACATCGATCTGTGGGAACTGAACGAGGCGTTCGCG
GTGCAGGTGCTCTATTGCCGCGACACGCTCGGGATTCCCGACGATCGGCTGAACGTGAACGGCGGCGCGATCGCGGTCGG
CCATCCGTACGGCGTATCGGGCGCGCGGCTCACCGGCCACGCGCTGATCGAGGGCAAGCGGCGCGGCGCGAAATACGTCG
TCGTGACGATGTGCATCGGCGGCGGGCAGGGTGCGGCGGGGCTGTTCGAGGTGGTGTGA

Upstream 100 bases:

>100_bases
CGCGTGCAGTCGGCCGAGGTTTGCCCGGGCGTCGATCCGTAGCCGCCGTCGTTCATTTCATCGCATATCGATCCACAGAA
TTCAGAATCAGGAGACTCGG

Downstream 100 bases:

>100_bases
CGGCGGCGCGCGCCGGAGCCGGCCGCGCGCCGTTCGAGCGCAACGGCGGGTCGGCGAGTCGATCCGGCGCGGCGGGTGTG
CGCCGGCGCTCGCGTCGTTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVG
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYG
ISKARQDEYGVNSQLRAAAAQAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGV
ITAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV

Sequences:

>Translated_392_residues
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVG
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYG
ISKARQDEYGVNSQLRAAAAQAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGV
ITAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
>Mature_391_residues
TEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVGV
PGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYGI
SKARQDEYGVNSQLRAAAAQAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGVI
TAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFAV
QVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=44.8101265822785, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI167614485, Length=366, Percent_Identity=38.7978142076503, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.1287128712871, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=35.5, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4504327, Length=393, Percent_Identity=31.5521628498728, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.133676092545, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=40.4358353510896, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=41.871921182266, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.6984924623116, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=37.7777777777778, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=30.8788598574822, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=38.0597014925373, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=35.8208955223881, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.1670822942643, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=29.6803652968037, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.3887468030691, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.3737373737374, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=414, Percent_Identity=32.3671497584541, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.25, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17648125, Length=364, Percent_Identity=39.2857142857143, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=34.1584158415842, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI17137578, Length=408, Percent_Identity=32.5980392156863, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40830; Mature: 40699

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPE
CCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCEEEEECCCCC
GATGANIARQIALRAGLPVGVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESI
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYGISKARQDEYGVNSQLRAAAA
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHH
QAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGV
HHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLL
EECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVSDIDLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCEEECCCCEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
EEEECCCCCCCEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPE
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCEEEEECCCCC
GATGANIARQIALRAGLPVGVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESI
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYGISKARQDEYGVNSQLRAAAA
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHH
QAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGV
HHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLL
EECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVSDIDLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCEEECCCCEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
EEEECCCCCCCEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]