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The map label for this gene is fba [H]

Identifier: 126451721

GI number: 126451721

Start: 821747

End: 822811

Strand: Direct

Name: fba [H]

Synonym: BURPS1106A_0841

Alternate gene names: 126451721

Gene position: 821747-822811 (Clockwise)

Preceding gene: 126452857

Following gene: 126455088

Centisome position: 20.6

GC content: 65.26

Gene sequence:

>1065_bases
ATGCCTCTCGTATCAATGCGTCAACTGCTGGATCACGCCGCGGAGAACGGCTACGGCCTGCCCGCGTTCAACGTGAACAA
CCTGGAACAGGTGCAGGCGATCATGGCGGCCGCCGACGAAGTCGGCGCGCCCGTGATCATGCAGGCATCGGCGGGCGCCC
GGAAGTACGCGGGCGAGGCGTTCCTGCGCCACCTGATCGAGGCGGCGGTGGAATCGTACCCGCACATTCCCGTCGTGATG
CACCAGGATCACGGCCAGTCGCCCGCCGTGTGCATGGCGGCGATCCGCAGCGGCTTCACGAGCGTGATGATGGACGGCTC
GCTCGAGGCCGACGGCAAGACGGTCGCATCGTACGAATACAATGTCGACGTGTCCCGCAAGGTCGTCGAGATGGCGCACT
CGATCGGCGTGACGGTCGAGGCCGAGCTCGGCGTGCTCGGCTCGCTCGAGACGATGAAGGGCGACAAGGAAGACGGCCAC
GGCGCCGAAGGCACGATGACGCGCGAGCAACTGCTGACGGACCCCGAGCAGGCCGCCGACTTCGTCAAGCTCACGCAGTG
CGACGCGCTCGCGATCGCGATCGGCACGTCGCACGGTGCGTACAAGTTCACGAAGAAGCCGACGGGCGACATCCTGTCGA
TCCAGCGGATCAAGGAGATTCACGCGCGCATTCCGAACACCCACCTCGTGATGCACGGGTCGTCGTCGGTGCCGCAGGAT
CTGCTCGCGGAAATCCGCGAGTTCGGCGGCGACATGAAGGAAACCTACGGCGTGCCCGTCGAGGAAATCCAGGAAGGCAT
CAAGCACGGCGTGCGCAAGGTCAACATCGACACCGACCTGCGTCTCGCGATCACGGGCGCGATCCGCCGCTACATGTTCG
AGAATCCGGGCAAGTTCGATCCGCGCGATTACCTGAAGCCCGCGCGCGAAGCGGCGAAGAAGATCTGCGTCGCGCGCTAT
CTGGCGTTCGGCTGCGAGGGCCAGGCGGCGAAGATCAAGCCGGTGCCGCTCGAGAAGATCGCCGAGAAGTACAAGGCGGG
CGACCTCGCGCAAGTGGTGCGTTGA

Upstream 100 bases:

>100_bases
GCTATTCGACGCTCGGCCGCGCCGGTCCGCCCGCCTTCGAAGCGGGGGCGGGCCCCGGACGCCGCGTAGGGCGCAAGGTT
TTCATTCAAGGAGTACCACA

Downstream 100 bases:

>100_bases
GTCTGTAGTACGATCTGGCCGGCCCGCGAGCGGGGCGGCCGGGCAAGTCCGGTCCGGCCCCGAAGCCGGCCGGCCCCGCC
GGGCCAAGCCGCCCGGCCGG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADEVGAPVIMQASAGARKYAGEAFLRHLIEAAVESYPHIPVVM
HQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFTKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQD
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKVNIDTDLRLAITGAIRRYMFENPGKFDPRDYLKPAREAAKKICVARY
LAFGCEGQAAKIKPVPLEKIAEKYKAGDLAQVVR

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADEVGAPVIMQASAGARKYAGEAFLRHLIEAAVESYPHIPVVM
HQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFTKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQD
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKVNIDTDLRLAITGAIRRYMFENPGKFDPRDYLKPAREAAKKICVARY
LAFGCEGQAAKIKPVPLEKIAEKYKAGDLAQVVR
>Mature_353_residues
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADEVGAPVIMQASAGARKYAGEAFLRHLIEAAVESYPHIPVVMH
QDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHG
AEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFTKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQDL
LAEIREFGGDMKETYGVPVEEIQEGIKHGVRKVNIDTDLRLAITGAIRRYMFENPGKFDPRDYLKPAREAAKKICVARYL
AFGCEGQAAKIKPVPLEKIAEKYKAGDLAQVVR

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.7386018237082, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789526, Length=316, Percent_Identity=33.8607594936709, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=29.483282674772, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789293, Length=357, Percent_Identity=24.6498599439776, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=365, Percent_Identity=26.3013698630137, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38442; Mature: 38310

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADEVGAPVIMQASAGARKYAGEA
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIEAAVESYPHIPVVMHQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDPEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHH
FVKLTQCDALAIAIGTSHGAYKFTKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQD
HHHHHHCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKVNIDTDLRLAITGAIRRYMFENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKICVARYLAFGCEGQAAKIKPVPLEKIAEKYKAGDLAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADEVGAPVIMQASAGARKYAGEA
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIEAAVESYPHIPVVMHQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDPEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHH
FVKLTQCDALAIAIGTSHGAYKFTKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQD
HHHHHHCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKVNIDTDLRLAITGAIRRYMFENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKICVARYLAFGCEGQAAKIKPVPLEKIAEKYKAGDLAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]