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The map label for this gene is cynR [H]

Identifier: 126445104

GI number: 126445104

Start: 1261541

End: 1262494

Strand: Reverse

Name: cynR [H]

Synonym: BURPS668_A1340

Alternate gene names: 126445104

Gene position: 1262494-1261541 (Counterclockwise)

Preceding gene: 126444455

Following gene: 126443285

Centisome position: 40.37

GC content: 63.1

Gene sequence:

>954_bases
ATGCTCAAGGAAAGCGTCGTGCTGCATGGCATCGGGCTCAAATACTTCGTGGAAGTCGCGCGCACTGGCTCGCTCGCAGC
GGCATCGCAACAGCTTCACGTCGCGGTGTCGGCGATCAGCCGGCAAATCGCAAAGCTCGAGGAGCAGGTGGGCACGCCAC
TGTTCGAGCGCATGCCGCGCGGCATGATCCTGACCGAAGCGGGCGAATTGCTCGTGCAGCATGCGCGCCGCGCGCTGATG
GATGGTGACGCGGTGCTTGCCGAGATATCGGAAATACATGCGCTCGGGCTTGGGATCGTGCGCATCGGCTGCACGGAGGG
TTTCACGCGCTGTTTTCTGCCGAGCGTCATGGCGACGCACTATCGCCAGCATCCGCGCACGCGCTTCGTGATGCGTTCAG
GTACGCCCGCGCAGGTCGAGCATTGGGTGGCAAGCGGCGAAGTCGATATGGGCCTCGCATTTTCGACGTCGACATCGACG
GCGTTGAGCGTCGAATACAGCGTCAAGGCGCCCGTCTGTGCGCTGCTGCCGCCGACACATCCTTTGGCGGGAAGAACGAG
CGTCACGCTCGACGACATTCTTCAGTACCCCACCGCCGTGCTAGATCGGGGCACCACCGTGCGCCAGTTGATCGACTTGT
GCTGTTCGGCACGCGGCGTGCATCTGGAGCCCATTCTGACGAGCAACAACTCGAGCGCGATGCACCATTTCGCCGCGCTC
ACCGGCACGATCACCCTCGGCAGCCAGGTCGCGCTCGAAGGCAATCCCGGGCCCCCGACACTCATCGCCATGCCCATCGA
CGAGCCATTGCTCAATGAGCGCCTTTTGCAGGTCACGGTGATGCGTGAGCGCCGCCTTCCGCCAGCGGTCGTTCAGTTTC
TGAAAACGCTGTCGAATGCGTTGCGCGAGAGTCAGGGCGCATCCGCGGCGCGCGCCAGGAGAAAAAAACGCTAA

Upstream 100 bases:

>100_bases
CGACGTCTCCGGAGGCGTGTGACTGCAATTAAGCCCAGTCTAGGAACACCAAAAATTCGCGACAATTTCAAAATTTGCGA
CTAGCATTGCCAAAAAGACA

Downstream 100 bases:

>100_bases
CCGGCTGCAGCAGGCAGCTCCACCGAGTATGACTGTGTGGCCGCTCAGGGCGGCGTGGCCGGCTGGGGCCGTCGGCGAAC
CTCCGGGTTGGACCACAAAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MLKESVVLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALM
DGDAVLAEISEIHALGLGIVRIGCTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTST
ALSVEYSVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAAL
TGTITLGSQVALEGNPGPPTLIAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR

Sequences:

>Translated_317_residues
MLKESVVLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALM
DGDAVLAEISEIHALGLGIVRIGCTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTST
ALSVEYSVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAAL
TGTITLGSQVALEGNPGPPTLIAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR
>Mature_317_residues
MLKESVVLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALM
DGDAVLAEISEIHALGLGIVRIGCTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTST
ALSVEYSVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAAL
TGTITLGSQVALEGNPGPPTLIAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=222, Percent_Identity=31.981981981982, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787879, Length=242, Percent_Identity=28.099173553719, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=25, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787601, Length=212, Percent_Identity=29.2452830188679, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787530, Length=235, Percent_Identity=25.9574468085106, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=26.8551236749117, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081904, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789204, Length=222, Percent_Identity=24.3243243243243, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=294, Percent_Identity=27.891156462585, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788296, Length=231, Percent_Identity=26.4069264069264, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788748, Length=274, Percent_Identity=24.0875912408759, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.9672131147541, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367136, Length=180, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=30.0546448087432, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790262, Length=181, Percent_Identity=28.1767955801105, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790399, Length=206, Percent_Identity=25.7281553398058, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789440, Length=113, Percent_Identity=30.0884955752212, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=26.9387755102041, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34306; Mature: 34306

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKESVVLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPR
CCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
GMILTEAGELLVQHARRALMDGDAVLAEISEIHALGLGIVRIGCTEGFTRCFLPSVMATH
CEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
YRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEYSVKAPVCALLPPTH
HHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEECCCCEEEECCCCC
PLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAAL
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
TGTITLGSQVALEGNPGPPTLIAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNA
HHEEEECCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRESQGASAARARRKKR
HHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MLKESVVLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPR
CCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
GMILTEAGELLVQHARRALMDGDAVLAEISEIHALGLGIVRIGCTEGFTRCFLPSVMATH
CEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
YRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEYSVKAPVCALLPPTH
HHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEECCCCEEEECCCCC
PLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAAL
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
TGTITLGSQVALEGNPGPPTLIAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNA
HHEEEECCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRESQGASAARARRKKR
HHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]