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The map label for this gene is hisG

Identifier: 126209473

GI number: 126209473

Start: 2246191

End: 2247090

Strand: Direct

Name: hisG

Synonym: APL_2019

Alternate gene names: 126209473

Gene position: 2246191-2247090 (Clockwise)

Preceding gene: 126209471

Following gene: 126209474

Centisome position: 98.76

GC content: 46.44

Gene sequence:

>900_bases
ATGACAACCACAAACCGTTTACGTATCGCTCTGCAGAAGAAAGGGCGTTTAAGCAAAGATTGCAACGAATTACTCAAGCA
ATGCGGCGTGAAAATTAACTGGAACGAACAGCGTTTAATCGCTTATGCGGAAAATATGCCGATTGAAATTTTACGGGTGC
GTGATGACGATATCCCGGGCTTGGTTTTTGAAGGCGTGGTGGATCTCGGCATTATCGGTGAAAATGTACTGGAAGAAGAG
GAACTCGGTCGTCTTGCTCGAGGCGAAAAAATCGAATATAAAAAACTACGTACCTTGGATTTCGGCGGCTGCCGCTTGTC
GTTAGCGATTGATCGTGACCGCACTTATAACGGCGTGCAAGATTTTGTTAATTCACGCATTGCCACCAGCTATCCGAACT
TACTCAAACGCTATATGAACGAAAAGGGCGTAGCGTTTAAAAGCACCTTACTTAACGGCTCTGTCGAAGTCGCCCCTTCC
GCCGGTTTAGCCGATGCGATTTGCGATTTGGTTTCATCCGGCGCAACTTTGGAAGCGAACGGCTTAAAAGAAGTGGAAGT
GATTTATCAATCCAAAGCCTGCTTGATTCAACGTGCCGAACCGCTTTCAACCGAAAAACAAGCGTTAGTCGATCGCCTAC
TCACCCGAATTCAAGGCGTACAACAAGCGGCGGAAAGTAAATACATTATGCTGCACGCCCCAAAAGATAAACTCAAAGAA
ATCACCGCACTTTTACCGGGTGTGGAAAACCCAACCATTCTCCCGCTCGCTAATGATTCCGCCCGTGTTGCGATGCATGT
AGTTAGCCAAGAAAACTTATTCTGGGAAACCATGGAACAACTGAAAGAAATGGGCGCAAGTTCGGTATTAGTGCTACCGA
TTGAGAAGATGTTGGCTTAG

Upstream 100 bases:

>100_bases
AGCAAAATCGCATATCGCAGCAAAATACACAACCTCTCGGAAGGCAACTTTCGAGAGGTTTTTTATATCCGAAATTTAAA
CACAACATGGGAAAAACAAA

Downstream 100 bases:

>100_bases
AAATCTCCCCCTAGCCCCCTCTTTATCAAAGAGGGGGAATAAACGGAGAAAGAAAAGCCCCCCTCTTTTGTAAAGAGGGG
CTGGGGGAGATTTAAAAACG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPGLVFEGVVDLGIIGENVLEEE
ELGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQDFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPS
AGLADAICDLVSSGATLEANGLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKE
ITALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA

Sequences:

>Translated_299_residues
MTTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPGLVFEGVVDLGIIGENVLEEE
ELGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQDFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPS
AGLADAICDLVSSGATLEANGLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKE
ITALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA
>Mature_298_residues
TTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPGLVFEGVVDLGIIGENVLEEEE
LGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQDFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPSA
GLADAICDLVSSGATLEANGLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKEI
TALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=71.4765100671141, Blast_Score=433, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=28.6195286195286, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ACTP2 (A3N3V7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054698.1
- ProteinModelPortal:   A3N3V7
- SMR:   A3N3V7
- STRING:   A3N3V7
- GeneID:   4850117
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_2019
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   A3N3V7
- ProtClustDB:   PRK00489
- BioCyc:   APLE416269:APL_2019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33227; Mature: 33096

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPG
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCCCCCC
LVFEGVVDLGIIGENVLEEEELGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQ
HHHHHHHHHHHHCHHHHCHHHHHHHHCCCCCCHHHHCEEECCCEEEEEEECCCCCCHHHH
DFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPSAGLADAICDLVSSGATLEAN
HHHHCCHHCCCHHHHHHHHCCCCCEEEHHHCCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKE
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
ITALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA
HHHHCCCCCCCEEEEECCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
TTTNRLRIALQKKGRLSKDCNELLKQCGVKINWNEQRLIAYAENMPIEILRVRDDDIPG
CCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCCCCCC
LVFEGVVDLGIIGENVLEEEELGRLARGEKIEYKKLRTLDFGGCRLSLAIDRDRTYNGVQ
HHHHHHHHHHHHCHHHHCHHHHHHHHCCCCCCHHHHCEEECCCEEEEEEECCCCCCHHHH
DFVNSRIATSYPNLLKRYMNEKGVAFKSTLLNGSVEVAPSAGLADAICDLVSSGATLEAN
HHHHCCHHCCCHHHHHHHHCCCCCEEEHHHCCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLKEVEVIYQSKACLIQRAEPLSTEKQALVDRLLTRIQGVQQAAESKYIMLHAPKDKLKE
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
ITALLPGVENPTILPLANDSARVAMHVVSQENLFWETMEQLKEMGASSVLVLPIEKMLA
HHHHCCCCCCCEEEEECCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA