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The map label for this gene is hisD [H]

Identifier: 126209474

GI number: 126209474

Start: 2247206

End: 2248492

Strand: Direct

Name: hisD [H]

Synonym: APL_2020

Alternate gene names: 126209474

Gene position: 2247206-2248492 (Clockwise)

Preceding gene: 126209473

Following gene: 126209475

Centisome position: 98.8

GC content: 47.63

Gene sequence:

>1287_bases
ATGCAAACCCTAATTTGGAAAAACTTAACCGAACAACAACGCAAAGAAGCGCTTACTCGCCCTGCGATTAGCTCTTCGCT
CAATATTCAACAAGCGGTTGATGCGATTCGTGAAAACGTATTGGCAAATGGCGACAAGGCATTATTTGAGCTTTCGGAAA
AATTCGACAAAGTGAAATTGGACAGCCTTGTCGTTTCAAAAACGCAGATTCAAGCGGCAAGCGATCGTTTATCAGATGAA
CTAAAACAGGCGATCCAAAATGCCAAAGCGAATATTGAAAAATTCCACACCGCACAAATTCCGCAGCCGGTGGACATCGA
AACTCAAGCAGGCGTGCGTTGCCAAGTGGTAACTCGCCCGATTAACCGTGTCGGCTTGTATATCCCAGGTGGTTCAGCAC
CGCTGTTTTCCACCGTGCTAATGCTTGCTATTCCAGCAAAAATTGCCGGCTGTAAAAAAGTGGTACTTTGCTCACCGCCA
CCGATTGCCGATGCGATTTTGTATGCGGCGAATTTGTGTGGCGTGGAAACCATTTACCAAGTGGGCGGTGCGCAAGCGAT
TGTAGCAATGGCATTCGGCACGGAAACGGTGGCAAAAGTAGATAAAATTTTCGGGCCGGGCAACAGCTTTGTAACTGAAG
CCAAACGCCAAGTTTCGCAAAGCGTAAACGGTGCAGCGATTGATATGCAAGCAGGTCCTTCGGAAGTGTTAGTGTTGGCG
GATGAAAATGCTGATCCTGATTTTGTGGCAAATGATTTACTTTCCCAAGCGGAACACGGTGCAGATAGCCAAGTGATTTT
AGTGACCCCAAGCGAAACTTTAGCAAAACAGACCGCACTTGCGATTGAAAACCAACTTGCAAAATTGCCGAGAAAAAAGA
CAGCTTGCAAAGCCCTAGAACACAGCCGAATTTTCATTGCCGAAAGCCTCGAACAAGCGGTCGAAATCAGCAACGAATAC
GCACCGGAACATTTAGTAGTTCAAGTGGAAAACGCCCGTTCTCTACTCGATAAACTCGACAACGCAGGCTCAATTTTCTT
AGGGGCATATTCGCCGGAAAGTATGGGTGACTACGCCAGTGGCACCAACCACGTTCTGCCGACTTACGGCTACACCCGCA
CTACATCGAGCTTAGGCTTAGCGGATTTCAGCAAACGAATGACCGTGCAAGAACTCACCCCGCAAGGTTTCAAAGATTTG
GCAAAAACGGTGGAAGTAATGGCAAGTGCGGAACAGTTGGAGGCGCATAAACAAGCGGTTTCGATTCGATTGGCGAAGAT
TGCCTAG

Upstream 100 bases:

>100_bases
CCCCTCTTTATCAAAGAGGGGGAATAAACGGAGAAAGAAAAGCCCCCCTCTTTTGTAAAGAGGGGCTGGGGGAGATTTAA
AAACGAAAATGGAGAACAAT

Downstream 100 bases:

>100_bases
GACGAGCCGTCCTAGGATCGATAATCCCAGCCCCGCTGGGGCTGAAAATTAGAAGATAAAGAGCCACAGAGTGGCTCGGA
TTAAGTAACCCCATACGACT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQTLIWKNLTEQQRKEALTRPAISSSLNIQQAVDAIRENVLANGDKALFELSEKFDKVKLDSLVVSKTQIQAASDRLSDE
LKQAIQNAKANIEKFHTAQIPQPVDIETQAGVRCQVVTRPINRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKVVLCSPP
PIADAILYAANLCGVETIYQVGGAQAIVAMAFGTETVAKVDKIFGPGNSFVTEAKRQVSQSVNGAAIDMQAGPSEVLVLA
DENADPDFVANDLLSQAEHGADSQVILVTPSETLAKQTALAIENQLAKLPRKKTACKALEHSRIFIAESLEQAVEISNEY
APEHLVVQVENARSLLDKLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTTSSLGLADFSKRMTVQELTPQGFKDL
AKTVEVMASAEQLEAHKQAVSIRLAKIA

Sequences:

>Translated_428_residues
MQTLIWKNLTEQQRKEALTRPAISSSLNIQQAVDAIRENVLANGDKALFELSEKFDKVKLDSLVVSKTQIQAASDRLSDE
LKQAIQNAKANIEKFHTAQIPQPVDIETQAGVRCQVVTRPINRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKVVLCSPP
PIADAILYAANLCGVETIYQVGGAQAIVAMAFGTETVAKVDKIFGPGNSFVTEAKRQVSQSVNGAAIDMQAGPSEVLVLA
DENADPDFVANDLLSQAEHGADSQVILVTPSETLAKQTALAIENQLAKLPRKKTACKALEHSRIFIAESLEQAVEISNEY
APEHLVVQVENARSLLDKLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTTSSLGLADFSKRMTVQELTPQGFKDL
AKTVEVMASAEQLEAHKQAVSIRLAKIA
>Mature_428_residues
MQTLIWKNLTEQQRKEALTRPAISSSLNIQQAVDAIRENVLANGDKALFELSEKFDKVKLDSLVVSKTQIQAASDRLSDE
LKQAIQNAKANIEKFHTAQIPQPVDIETQAGVRCQVVTRPINRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKVVLCSPP
PIADAILYAANLCGVETIYQVGGAQAIVAMAFGTETVAKVDKIFGPGNSFVTEAKRQVSQSVNGAAIDMQAGPSEVLVLA
DENADPDFVANDLLSQAEHGADSQVILVTPSETLAKQTALAIENQLAKLPRKKTACKALEHSRIFIAESLEQAVEISNEY
APEHLVVQVENARSLLDKLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTTSSLGLADFSKRMTVQELTPQGFKDL
AKTVEVMASAEQLEAHKQAVSIRLAKIA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=419, Percent_Identity=67.3031026252983, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=48.936170212766, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45996; Mature: 45996

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLIWKNLTEQQRKEALTRPAISSSLNIQQAVDAIRENVLANGDKALFELSEKFDKVKL
CCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DSLVVSKTQIQAASDRLSDELKQAIQNAKANIEKFHTAQIPQPVDIETQAGVRCQVVTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
INRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKVVLCSPPPIADAILYAANLCGVETIYQ
CCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHH
VGGAQAIVAMAFGTETVAKVDKIFGPGNSFVTEAKRQVSQSVNGAAIDMQAGPSEVLVLA
CCCCCEEEEEHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEE
DENADPDFVANDLLSQAEHGADSQVILVTPSETLAKQTALAIENQLAKLPRKKTACKALE
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HSRIFIAESLEQAVEISNEYAPEHLVVQVENARSLLDKLDNAGSIFLGAYSPESMGDYAS
HCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTTSSLGLADFSKRMTVQELTPQGFKDLAKTVEVMASAEQLEAHKQAV
CCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SIRLAKIA
HHEEEECC
>Mature Secondary Structure
MQTLIWKNLTEQQRKEALTRPAISSSLNIQQAVDAIRENVLANGDKALFELSEKFDKVKL
CCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DSLVVSKTQIQAASDRLSDELKQAIQNAKANIEKFHTAQIPQPVDIETQAGVRCQVVTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
INRVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKVVLCSPPPIADAILYAANLCGVETIYQ
CCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHH
VGGAQAIVAMAFGTETVAKVDKIFGPGNSFVTEAKRQVSQSVNGAAIDMQAGPSEVLVLA
CCCCCEEEEEHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEE
DENADPDFVANDLLSQAEHGADSQVILVTPSETLAKQTALAIENQLAKLPRKKTACKALE
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HSRIFIAESLEQAVEISNEYAPEHLVVQVENARSLLDKLDNAGSIFLGAYSPESMGDYAS
HCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTTSSLGLADFSKRMTVQELTPQGFKDLAKTVEVMASAEQLEAHKQAV
CCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SIRLAKIA
HHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA