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The map label for this gene is nudH

Identifier: 126209357

GI number: 126209357

Start: 2128145

End: 2128765

Strand: Reverse

Name: nudH

Synonym: APL_1897

Alternate gene names: 126209357

Gene position: 2128765-2128145 (Counterclockwise)

Preceding gene: 126209358

Following gene: 126209356

Centisome position: 93.59

GC content: 42.35

Gene sequence:

>621_bases
GTGATCGATTTCGATGGCTACCGCCCAAATGTTGGTATCGTCATTTGTAATAAAGCAGGACAAGTTCTGTGGGCAAAACG
GTTTGGACAAAACTCTTGGCAATTTCCGCAAGGCGGGATTAACGAGGGCGAAAACATTGAAACGGCAATGTACCGTGAGC
TTTATGAAGAAGTCGGCTTAACTAAAAAAGATGTGCGATTATTATGGGCGTCTAAATATTGGCTGAAGTATAAATTACCC
AAACGCTTAGTGCGTAGTGACGGTTCTCAGCTGGTGTGTATCGGGCAAAAACAACGTTGGTTTTTGCTGCAACTTCTCAG
TGATGAAAATTTGATTGATTTAAAAACGACTAAAAGCCCGGAATTTGACGGTTGGCGTTGGGTTAGCTTTTGGTATCCGG
TGCGTCAGGTGGTTTCGTTTAAGCGCGATGTTTATCGCAAAGTGATGAAAGAATTTGCCGGCGTACTATTAAATGAATCC
AAAAAACCAGAAACGGTTGAAAAACCCCGTGTAGAACGTACGGAAAAGCGCGATTTTCAAAAACGTGATAATCAAAAACG
CGAATTTCGCAAATCTGCTCGTATGTGGAACAATTCGCATCAGAAAGGAAAAGCGCAATGA

Upstream 100 bases:

>100_bases
GAGTTATCTACAAAATTGGCTTTAGAGGTTGTTCTAAGACGGAAAGTGTGAAACAATCTCATTCATTTTCTCTTTACCTA
AAAATAAATAAGGTGGTCAA

Downstream 100 bases:

>100_bases
TAGAAGTATTTTTGAGTTGTCTTGTCGTAGGTTCGGCGGTCGGCTTCTTAGCCGGTTTATTCGGTATCGGCGGCGGTTTG
ATCATCGTACCGAGTTTGGT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGLTKKDVRLLWASKYWLKYKLP
KRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSPEFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNES
KKPETVEKPRVERTEKRDFQKRDNQKREFRKSARMWNNSHQKGKAQ

Sequences:

>Translated_206_residues
MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGLTKKDVRLLWASKYWLKYKLP
KRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSPEFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNES
KKPETVEKPRVERTEKRDFQKRDNQKREFRKSARMWNNSHQKGKAQ
>Mature_206_residues
MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGLTKKDVRLLWASKYWLKYKLP
KRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSPEFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNES
KKPETVEKPRVERTEKRDFQKRDNQKREFRKSARMWNNSHQKGKAQ

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=176, Percent_Identity=67.6136363636364, Blast_Score=252, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_ACTP2 (A3N3J1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054582.1
- ProteinModelPortal:   A3N3J1
- SMR:   A3N3J1
- STRING:   A3N3J1
- GeneID:   4848701
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1897
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A3N3J1
- ProtClustDB:   PRK00714
- BioCyc:   APLE416269:APL_1897-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 24616; Mature: 24616

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGL
CCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TKKDVRLLWASKYWLKYKLPKRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSP
CHHHHHHHHHHHHHHEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNESKKPETVEKPRVERTEKRDFQ
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
KRDNQKREFRKSARMWNNSHQKGKAQ
HHCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIDFDGYRPNVGIVICNKAGQVLWAKRFGQNSWQFPQGGINEGENIETAMYRELYEEVGL
CCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TKKDVRLLWASKYWLKYKLPKRLVRSDGSQLVCIGQKQRWFLLQLLSDENLIDLKTTKSP
CHHHHHHHHHHHHHHEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EFDGWRWVSFWYPVRQVVSFKRDVYRKVMKEFAGVLLNESKKPETVEKPRVERTEKRDFQ
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
KRDNQKREFRKSARMWNNSHQKGKAQ
HHCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA