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The map label for this gene is tmk

Identifier: 126209279

GI number: 126209279

Start: 2039699

End: 2040325

Strand: Reverse

Name: tmk

Synonym: APL_1817

Alternate gene names: 126209279

Gene position: 2040325-2039699 (Counterclockwise)

Preceding gene: 126209280

Following gene: 126209278

Centisome position: 89.71

GC content: 44.66

Gene sequence:

>627_bases
ATGCGTGGAAAATTTATTGTTCTTGAAGGTTTAGAAGGTGCAGGCAAAACCACTGCACACCAAGTGATTTTAGCTCAGTT
GGAAAAAGCGGGCAAAAACGTGGTACAAACCCGTGAACCAGGCGGTACGCCGCTTGCGGAAAAACTACGCCATTTAATCA
AACACGAAACCGAAGAAGCGGTTAGTGACAAAGCCGAATTACTGATGTTATATGCGGCACGTATTCAATTAGTCGAAAAC
GTGATTAAACCGGCATTGGCAGAAGGCAAATGGGTGCTGGGCGATCGTCACGATATGTCTTCGCAGGCTTATCAAGGCGG
TGGACGTCAAATTGATCGCCACTTACTCGAAACTTTAAAAGAAACCGTGCTAGGTAACTTTGAACCGGATTTGACCATTT
ATCTTGATATCGATCCTGCGGTCGGCTTAGCTCGCGCACGTGGTCGCGGTGAACTGGATCGTATCGAACAGCAAAGCCTC
GATTTCTTTTATCGCACACGCCAACGTTATTTGGAACTGACACAAAATAACGAGAAAGCGGTAATTATTAATGCGGAACA
ATCTATCGAACAAGTTGCCGCTGACATTCAACAAGCGGTCGAAAACTTCTTAAAAATTGCAAAATAA

Upstream 100 bases:

>100_bases
CGGCGGACACAAATTTAGTAAAAATCTAGACCAACACAACCAAGCGGTTCGTGACTGGATCAAAATCGAACGAAACAAAA
AACTTGAGAAGAAATAAGAA

Downstream 100 bases:

>100_bases
ATATGCTATATCCTTGGCTTCAACACACTTATCAACAACTTACAGAATCCTTTTTGCATGGGCGTGGTCATCACGCCCTG
TTATTTAAAACCGATTCGGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRGKFIVLEGLEGAGKTTAHQVILAQLEKAGKNVVQTREPGGTPLAEKLRHLIKHETEEAVSDKAELLMLYAARIQLVEN
VIKPALAEGKWVLGDRHDMSSQAYQGGGRQIDRHLLETLKETVLGNFEPDLTIYLDIDPAVGLARARGRGELDRIEQQSL
DFFYRTRQRYLELTQNNEKAVIINAEQSIEQVAADIQQAVENFLKIAK

Sequences:

>Translated_208_residues
MRGKFIVLEGLEGAGKTTAHQVILAQLEKAGKNVVQTREPGGTPLAEKLRHLIKHETEEAVSDKAELLMLYAARIQLVEN
VIKPALAEGKWVLGDRHDMSSQAYQGGGRQIDRHLLETLKETVLGNFEPDLTIYLDIDPAVGLARARGRGELDRIEQQSL
DFFYRTRQRYLELTQNNEKAVIINAEQSIEQVAADIQQAVENFLKIAK
>Mature_208_residues
MRGKFIVLEGLEGAGKTTAHQVILAQLEKAGKNVVQTREPGGTPLAEKLRHLIKHETEEAVSDKAELLMLYAARIQLVEN
VIKPALAEGKWVLGDRHDMSSQAYQGGGRQIDRHLLETLKETVLGNFEPDLTIYLDIDPAVGLARARGRGELDRIEQQSL
DFFYRTRQRYLELTQNNEKAVIINAEQSIEQVAADIQQAVENFLKIAK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=61.7224880382775, Blast_Score=261, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ACTP2 (A3N3B3)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054504.1
- ProteinModelPortal:   A3N3B3
- SMR:   A3N3B3
- STRING:   A3N3B3
- GeneID:   4850003
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1817
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   A3N3B3
- ProtClustDB:   PRK00698
- BioCyc:   APLE416269:APL_1817-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23311; Mature: 23311

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKFIVLEGLEGAGKTTAHQVILAQLEKAGKNVVQTREPGGTPLAEKLRHLIKHETEEA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VSDKAELLMLYAARIQLVENVIKPALAEGKWVLGDRHDMSSQAYQGGGRQIDRHLLETLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
ETVLGNFEPDLTIYLDIDPAVGLARARGRGELDRIEQQSLDFFYRTRQRYLELTQNNEKA
HHHCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VIINAEQSIEQVAADIQQAVENFLKIAK
EEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGKFIVLEGLEGAGKTTAHQVILAQLEKAGKNVVQTREPGGTPLAEKLRHLIKHETEEA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VSDKAELLMLYAARIQLVENVIKPALAEGKWVLGDRHDMSSQAYQGGGRQIDRHLLETLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
ETVLGNFEPDLTIYLDIDPAVGLARARGRGELDRIEQQSLDFFYRTRQRYLELTQNNEKA
HHHCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VIINAEQSIEQVAADIQQAVENFLKIAK
EEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA