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The map label for this gene is fucO [H]

Identifier: 126209153

GI number: 126209153

Start: 1920020

End: 1921171

Strand: Direct

Name: fucO [H]

Synonym: APL_1689

Alternate gene names: 126209153

Gene position: 1920020-1921171 (Clockwise)

Preceding gene: 126209152

Following gene: 126209154

Centisome position: 84.42

GC content: 44.36

Gene sequence:

>1152_bases
ATGTCAAATCGTTTGATTCTGAATGAAACCAGTTACCACGGTAAAGGCGCGATTCAGCATATTGTGTATGAAGTCAAAAG
TCGCAGTTTTAAGAAAGCGTTAGTGGTTACCGATAAAGATTTAATTAAGTATAACGTCGCTTCTAAAGTAACCGATTTAT
TGGATACGGCAGGTTTACCGTATGAAATTTTTGATGAAGTTAAAGCGAATCCGTCGGTCGATGTGATCAAAGCCGGTGTA
GAAAAATTTAAAGCATCCGGTGCGGATTATCTGATTGCCATCGGTGGCGGATCCCCGATTGATAGTGCGAAAGCAATCGG
GATTATCATCAATAACCCTGAATTTAGCGATGTATTATCGTTAGAAGGTGTGGCACCGACGCATCAAAAATGTATTCCGA
TCATTGCAGTACCAACCACCGCTGGTACGGCAGCAGAGGTTACAATTAATTACGTGATTACCGATGAAGAGAAAAAACGT
AAGTTCGTTTGTGTGGATGTGCACGACGTACCGGCGGTTGCGGTGGTTGATCCGGATATGATGTCCTCTATGCCGAAAGG
CTTAACCGCGGCAACCGGTATGGATGCTTTAACCCATGCGATTGAAGGTTATATCACTAAAGCGGCGTGGGAATTAACCG
ATGCGTTACACTTAAAAGCGATCGAAATTATTGCTCGTAGCTTACGCAGTGCGGTGGAAAATGATCCGCAAGGGCGTGAG
GGAATGGCTCTCGGTCAATATGTTGCCGGTATGGGTTTCTCAAATGTCGGTTTGGGTGTAGTACACGGAATGGCACATCC
TCTTTCTGCTTATTACGATACGCCGCACGGTATCGCCAACGCGGTGTTATTACCTTATGTGATGGAATTTAATAAAAATT
ACACGGGTGAGAAATATCGTGAAATCGCACGCGCGATGGGCGTGAAAGGCGTGGATGAAATGGCTCAAGCGGAATACCGA
GATGCAGCAGTAGCAGCGGTAAAACAGCTTGCGATAGATGTCGGTATTCCGGAAAAACTTTCGCAAATCGGAGTAAAAGA
AGAAGATTTGGTTGCGCTTTCTATTGATGCGTTTAACGACGTATGTACGCCGGGAAATCCGAGAGAGTGTACGGCGGAAG
AAATTTTGGAAGTATATAAATTAGCTTATTAA

Upstream 100 bases:

>100_bases
GCGGTCGAGTTTTCCATAAAATTTGCAAGAAAATCGGAAAATAAGACCGCTTACCTTCCTTATCGGAAAATGAATTTTTA
ACTTTAAGAAGGAATATTTT

Downstream 100 bases:

>100_bases
TACTCACCTAAAAAAATCAACCGGTCAGGCGAATAACTTGACCGGTTTTTTTATGTTAAGTAATAAAAAATTATCCTATT
TAAATTAATAGATTGAAATT

Product: L-1,2-propanediol oxidoreductase

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSNRLILNETSYHGKGAIQHIVYEVKSRSFKKALVVTDKDLIKYNVASKVTDLLDTAGLPYEIFDEVKANPSVDVIKAGV
EKFKASGADYLIAIGGGSPIDSAKAIGIIINNPEFSDVLSLEGVAPTHQKCIPIIAVPTTAGTAAEVTINYVITDEEKKR
KFVCVDVHDVPAVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITKAAWELTDALHLKAIEIIARSLRSAVENDPQGRE
GMALGQYVAGMGFSNVGLGVVHGMAHPLSAYYDTPHGIANAVLLPYVMEFNKNYTGEKYREIARAMGVKGVDEMAQAEYR
DAAVAAVKQLAIDVGIPEKLSQIGVKEEDLVALSIDAFNDVCTPGNPRECTAEEILEVYKLAY

Sequences:

>Translated_383_residues
MSNRLILNETSYHGKGAIQHIVYEVKSRSFKKALVVTDKDLIKYNVASKVTDLLDTAGLPYEIFDEVKANPSVDVIKAGV
EKFKASGADYLIAIGGGSPIDSAKAIGIIINNPEFSDVLSLEGVAPTHQKCIPIIAVPTTAGTAAEVTINYVITDEEKKR
KFVCVDVHDVPAVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITKAAWELTDALHLKAIEIIARSLRSAVENDPQGRE
GMALGQYVAGMGFSNVGLGVVHGMAHPLSAYYDTPHGIANAVLLPYVMEFNKNYTGEKYREIARAMGVKGVDEMAQAEYR
DAAVAAVKQLAIDVGIPEKLSQIGVKEEDLVALSIDAFNDVCTPGNPRECTAEEILEVYKLAY
>Mature_382_residues
SNRLILNETSYHGKGAIQHIVYEVKSRSFKKALVVTDKDLIKYNVASKVTDLLDTAGLPYEIFDEVKANPSVDVIKAGVE
KFKASGADYLIAIGGGSPIDSAKAIGIIINNPEFSDVLSLEGVAPTHQKCIPIIAVPTTAGTAAEVTINYVITDEEKKRK
FVCVDVHDVPAVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITKAAWELTDALHLKAIEIIARSLRSAVENDPQGREG
MALGQYVAGMGFSNVGLGVVHGMAHPLSAYYDTPHGIANAVLLPYVMEFNKNYTGEKYREIARAMGVKGVDEMAQAEYRD
AAVAAVKQLAIDVGIPEKLSQIGVKEEDLVALSIDAFNDVCTPGNPRECTAEEILEVYKLAY

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=382, Percent_Identity=26.9633507853403, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789163, Length=383, Percent_Identity=64.2297650130548, Blast_Score=509, Evalue=1e-146,
Organism=Escherichia coli, GI48994951, Length=355, Percent_Identity=43.3802816901408, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87082107, Length=371, Percent_Identity=36.6576819407008, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1787493, Length=403, Percent_Identity=32.7543424317618, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1789386, Length=322, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=391, Percent_Identity=27.3657289002558, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=377, Percent_Identity=38.4615384615385, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24657991, Length=416, Percent_Identity=25.2403846153846, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 41159; Mature: 41027

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRLILNETSYHGKGAIQHIVYEVKSRSFKKALVVTDKDLIKYNVASKVTDLLDTAGLP
CCCCEEEECCCCCCCHHHHHHHHHHHHCCHHEEEEEECHHHHHHHHHHHHHHHHHHCCCC
YEIFDEVKANPSVDVIKAGVEKFKASGADYLIAIGGGSPIDSAKAIGIIINNPEFSDVLS
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHC
LEGVAPTHQKCIPIIAVPTTAGTAAEVTINYVITDEEKKRKFVCVDVHDVPAVAVVDPDM
CCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCEEEEECCHH
MSSMPKGLTAATGMDALTHAIEGYITKAAWELTDALHLKAIEIIARSLRSAVENDPQGRE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GMALGQYVAGMGFSNVGLGVVHGMAHPLSAYYDTPHGIANAVLLPYVMEFNKNYTGEKYR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
EIARAMGVKGVDEMAQAEYRDAAVAAVKQLAIDVGIPEKLSQIGVKEEDLVALSIDAFND
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEEECCCC
VCTPGNPRECTAEEILEVYKLAY
CCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNRLILNETSYHGKGAIQHIVYEVKSRSFKKALVVTDKDLIKYNVASKVTDLLDTAGLP
CCCEEEECCCCCCCHHHHHHHHHHHHCCHHEEEEEECHHHHHHHHHHHHHHHHHHCCCC
YEIFDEVKANPSVDVIKAGVEKFKASGADYLIAIGGGSPIDSAKAIGIIINNPEFSDVLS
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHC
LEGVAPTHQKCIPIIAVPTTAGTAAEVTINYVITDEEKKRKFVCVDVHDVPAVAVVDPDM
CCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCEEEEECCHH
MSSMPKGLTAATGMDALTHAIEGYITKAAWELTDALHLKAIEIIARSLRSAVENDPQGRE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GMALGQYVAGMGFSNVGLGVVHGMAHPLSAYYDTPHGIANAVLLPYVMEFNKNYTGEKYR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
EIARAMGVKGVDEMAQAEYRDAAVAAVKQLAIDVGIPEKLSQIGVKEEDLVALSIDAFND
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEEECCCC
VCTPGNPRECTAEEILEVYKLAY
CCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]