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The map label for this gene is selA

Identifier: 126209026

GI number: 126209026

Start: 1787279

End: 1788664

Strand: Reverse

Name: selA

Synonym: APL_1562

Alternate gene names: 126209026

Gene position: 1788664-1787279 (Counterclockwise)

Preceding gene: 126209028

Following gene: 126209025

Centisome position: 78.64

GC content: 44.01

Gene sequence:

>1386_bases
ATGCAAAAATTATTTCGTACCATTCCCGCTATCGACAAATTGATGAAAAAACCTCAAGGTATTGATTTAATTGAAAGATT
CGGACATCAAGCCTTTGTTCAAGAAGCGCGTATATTGATAGAAAACGCACGTGAACAGATTATTAAACAGCAATGTTTAC
CTGCGTTTATGAACGAACAGTCTTCTATTTTTAGCTTGATTGAACAAAATCTGCAAAAAAAGCGTATGGTATCGAGTAAA
ACCGTATTTAATCTGACCGGTACGGTGTTACATACCAATTTAGGGCGCGGATTGTGGTCGGAAAATGCGATTACCGCCGC
CACCAATGCGATGCGAAATAACGTTGCGTTGGAATTTGATATTGACGAAGGGAAACGCAGCCATCGAGATATTTATATTT
CTCAATTAATTCAACAGCTTACCGGTGCGGAAGCGGCTTGTATCGTCAATAATAATGCAGCGGCGGTATTGTTGATGTTG
GCGACTTTTGCACAGGGTAAAGAAGTGATTGTTTCTCGCGGCGAGCTAGTGGAAATCGGCGGTGCGTTTCGTATTCCGGA
TATTATGGCGCAAGCCGGCTGTAAATTGGTGGAAGTCGGCACAACCAACCGTACCCATTTACGGGATTATCGCAACGCAA
TTAATGAAAATACCGCTTTCTTAATGAAAGTGCATACCAGTAATTACCATATTCAAGGTTTTACCAAATCGGTTTCGGAA
GAAGAATTGGTGGAATTGGCGAAAGAATTTGATTTGCCGGTTATCAGTGATTTGGGTAGCGGTTCGCTGACGGATATGGC
GGTACTCGGCTTGCCGGCCGAACCGATGGTACAACAGAAAGTGGCGGCGGGCGTCGATTTGGTTTCGTTTTCTTGCGATA
AACTATTGGGCGGGCCGCAAGCGGGTATTATTGTTGGGAAAAAGGCATTGATTGACGGACTGCAATCGCATCCGCTTAAG
AGAGTATTGCGCTGCGATAAAGTGATTTTATCGGCATTGGAAGCGACACTTCGTCATTATCTTTTCCCGGAAAAATTAAC
CGATGAAGTGCCGACGTTTCAGCTTTTAACCCAATCAATTGAAACTTTGCAGAACAAAGCGGAACGTTTAAAAGCGGTGC
TGAACAAGCGGTTGGATTCTCGCTATATTTTGCAAGTGGAACCGAGTCTTGCTCAGATCGGGAGCGGCTCGTTACCGACC
GAAACCTTAGCTTCGGTTGCGGTCACGGTTTTTGCCGAGAAACAGAGCGATTTACTTGAATTAGAAAAAAGATTTAAAGC
CTTGCCAAGTCCGATAATCGGGCGATTTGCTCAGCAAAAATTTTGGTTGGACGTGCGTTCGGCGGCACAGTTTGAACAGT
TGTTAAATATGTTGGAGGAAGCATGA

Upstream 100 bases:

>100_bases
AGTCCTGCCACCTCACCGGAGATGACTCGCTTCCTTTAAAGAGTAGCGGTATTCTACTTTATTTATTAGAATTGTCCAAA
ATTTCTTAACATTTTTTATT

Downstream 100 bases:

>100_bases
TTTTTGTTACCAGCGGACACGTGGATCATGGTAAAACGACCTTGTTACAAGCCTTAACAGGTAACGATACCGCTCATTTA
CCGGAAGAAAAAAAGCGTGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MQKLFRTIPAIDKLMKKPQGIDLIERFGHQAFVQEARILIENAREQIIKQQCLPAFMNEQSSIFSLIEQNLQKKRMVSSK
TVFNLTGTVLHTNLGRGLWSENAITAATNAMRNNVALEFDIDEGKRSHRDIYISQLIQQLTGAEAACIVNNNAAAVLLML
ATFAQGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGTTNRTHLRDYRNAINENTAFLMKVHTSNYHIQGFTKSVSE
EELVELAKEFDLPVISDLGSGSLTDMAVLGLPAEPMVQQKVAAGVDLVSFSCDKLLGGPQAGIIVGKKALIDGLQSHPLK
RVLRCDKVILSALEATLRHYLFPEKLTDEVPTFQLLTQSIETLQNKAERLKAVLNKRLDSRYILQVEPSLAQIGSGSLPT
ETLASVAVTVFAEKQSDLLELEKRFKALPSPIIGRFAQQKFWLDVRSAAQFEQLLNMLEEA

Sequences:

>Translated_461_residues
MQKLFRTIPAIDKLMKKPQGIDLIERFGHQAFVQEARILIENAREQIIKQQCLPAFMNEQSSIFSLIEQNLQKKRMVSSK
TVFNLTGTVLHTNLGRGLWSENAITAATNAMRNNVALEFDIDEGKRSHRDIYISQLIQQLTGAEAACIVNNNAAAVLLML
ATFAQGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGTTNRTHLRDYRNAINENTAFLMKVHTSNYHIQGFTKSVSE
EELVELAKEFDLPVISDLGSGSLTDMAVLGLPAEPMVQQKVAAGVDLVSFSCDKLLGGPQAGIIVGKKALIDGLQSHPLK
RVLRCDKVILSALEATLRHYLFPEKLTDEVPTFQLLTQSIETLQNKAERLKAVLNKRLDSRYILQVEPSLAQIGSGSLPT
ETLASVAVTVFAEKQSDLLELEKRFKALPSPIIGRFAQQKFWLDVRSAAQFEQLLNMLEEA
>Mature_461_residues
MQKLFRTIPAIDKLMKKPQGIDLIERFGHQAFVQEARILIENAREQIIKQQCLPAFMNEQSSIFSLIEQNLQKKRMVSSK
TVFNLTGTVLHTNLGRGLWSENAITAATNAMRNNVALEFDIDEGKRSHRDIYISQLIQQLTGAEAACIVNNNAAAVLLML
ATFAQGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGTTNRTHLRDYRNAINENTAFLMKVHTSNYHIQGFTKSVSE
EELVELAKEFDLPVISDLGSGSLTDMAVLGLPAEPMVQQKVAAGVDLVSFSCDKLLGGPQAGIIVGKKALIDGLQSHPLK
RVLRCDKVILSALEATLRHYLFPEKLTDEVPTFQLLTQSIETLQNKAERLKAVLNKRLDSRYILQVEPSLAQIGSGSLPT
ETLASVAVTVFAEKQSDLLELEKRFKALPSPIIGRFAQQKFWLDVRSAAQFEQLLNMLEEA

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=459, Percent_Identity=55.7734204793028, Blast_Score=477, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_ACTP2 (A3N2L0)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054251.1
- ProteinModelPortal:   A3N2L0
- STRING:   A3N2L0
- GeneID:   4849302
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1562
- eggNOG:   COG1921
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- PhylomeDB:   A3N2L0
- ProtClustDB:   PRK04311
- BioCyc:   APLE416269:APL_1562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 51094; Mature: 51094

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLFRTIPAIDKLMKKPQGIDLIERFGHQAFVQEARILIENAREQIIKQQCLPAFMNEQ
CHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SSIFSLIEQNLQKKRMVSSKTVFNLTGTVLHTNLGRGLWSENAITAATNAMRNNVALEFD
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEE
IDEGKRSHRDIYISQLIQQLTGAEAACIVNNNAAAVLLMLATFAQGKEVIVSRGELVEIG
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCEEEEC
GAFRIPDIMAQAGCKLVEVGTTNRTHLRDYRNAINENTAFLMKVHTSNYHIQGFTKSVSE
CCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHCCCH
EELVELAKEFDLPVISDLGSGSLTDMAVLGLPAEPMVQQKVAAGVDLVSFSCDKLLGGPQ
HHHHHHHHHCCCCHHHCCCCCCCHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
AGIIVGKKALIDGLQSHPLKRVLRCDKVILSALEATLRHYLFPEKLTDEVPTFQLLTQSI
CCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHH
ETLQNKAERLKAVLNKRLDSRYILQVEPSLAQIGSGSLPTETLASVAVTVFAEKQSDLLE
HHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LEKRFKALPSPIIGRFAQQKFWLDVRSAAQFEQLLNMLEEA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKLFRTIPAIDKLMKKPQGIDLIERFGHQAFVQEARILIENAREQIIKQQCLPAFMNEQ
CHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SSIFSLIEQNLQKKRMVSSKTVFNLTGTVLHTNLGRGLWSENAITAATNAMRNNVALEFD
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEE
IDEGKRSHRDIYISQLIQQLTGAEAACIVNNNAAAVLLMLATFAQGKEVIVSRGELVEIG
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCEEEEC
GAFRIPDIMAQAGCKLVEVGTTNRTHLRDYRNAINENTAFLMKVHTSNYHIQGFTKSVSE
CCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHCCCH
EELVELAKEFDLPVISDLGSGSLTDMAVLGLPAEPMVQQKVAAGVDLVSFSCDKLLGGPQ
HHHHHHHHHCCCCHHHCCCCCCCHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
AGIIVGKKALIDGLQSHPLKRVLRCDKVILSALEATLRHYLFPEKLTDEVPTFQLLTQSI
CCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHH
ETLQNKAERLKAVLNKRLDSRYILQVEPSLAQIGSGSLPTETLASVAVTVFAEKQSDLLE
HHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LEKRFKALPSPIIGRFAQQKFWLDVRSAAQFEQLLNMLEEA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA