Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 126208550

GI number: 126208550

Start: 1247188

End: 1247505

Strand: Reverse

Name: trxA [H]

Synonym: APL_1078

Alternate gene names: 126208550

Gene position: 1247505-1247188 (Counterclockwise)

Preceding gene: 126208551

Following gene: 126208549

Centisome position: 54.85

GC content: 44.65

Gene sequence:

>318_bases
ATGACTTTACAAGTTACTGACGCAACTTTTGAACAAGAAGTATTAAAATCGGACGTACCGGTATTATTAGACTTTTGGGC
GCCGTGGTGCGGTCCTTGCCGTATGGTGGCTCCAATCTTAGACGAATTATCGGAAGAGTTCGCGGGTCGTGCGAAAATTG
CTAAAGTGAACGTGGACGAGAACCAACAAATTCCGGCACAATTCGGTATTCGTTCAATCCCGACGTTAATCCTTTTCAAA
AACGGTGAAGTGGTTGCAACTCAAGTCGGCGCATTACCGAAATCACAATTAAGCGCATTTGTCGAACAAGCGCTTTAA

Upstream 100 bases:

>100_bases
TTACTTGAAATTGAGTAAACGAACCCTTATCTTACGGTGTAACTTAACGCCACGGTCAAGTGGCGTTTTCTTTTCGGATT
ATTAATAAGGAAAACAAATT

Downstream 100 bases:

>100_bases
TCTTTAATTTCTAAATCGGGGCGGGTAATTTCTCGCCCTTTTTATTTGCAAAATTGTTAAAAAAGACCGCTATTTGTTCT
ATAAAGCCTAGCAAAATGAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MTLQVTDATFEQEVLKSDVPVLLDFWAPWCGPCRMVAPILDELSEEFAGRAKIAKVNVDENQQIPAQFGIRSIPTLILFK
NGEVVATQVGALPKSQLSAFVEQAL

Sequences:

>Translated_105_residues
MTLQVTDATFEQEVLKSDVPVLLDFWAPWCGPCRMVAPILDELSEEFAGRAKIAKVNVDENQQIPAQFGIRSIPTLILFK
NGEVVATQVGALPKSQLSAFVEQAL
>Mature_104_residues
TLQVTDATFEQEVLKSDVPVLLDFWAPWCGPCRMVAPILDELSEEFAGRAKIAKVNVDENQQIPAQFGIRSIPTLILFKN
GEVVATQVGALPKSQLSAFVEQAL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=105, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=32.3232323232323, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI42794771, Length=102, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI224493972, Length=102, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI50592994, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=54.3689320388349, Blast_Score=135, Evalue=5e-34,
Organism=Escherichia coli, GI1788936, Length=104, Percent_Identity=45.1923076923077, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI87081747, Length=96, Percent_Identity=37.5, Blast_Score=70, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=40.625, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17556044, Length=83, Percent_Identity=36.144578313253, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=42.2535211267606, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=84, Percent_Identity=39.2857142857143, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=36.1111111111111, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=36.1111111111111, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=35.5555555555556, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=102, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=38.6666666666667, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=93, Percent_Identity=39.7849462365591, Blast_Score=78, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=36.1702127659575, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=31.1111111111111, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=93, Percent_Identity=39.7849462365591, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17648013, Length=96, Percent_Identity=43.75, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=96, Percent_Identity=43.75, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=42.6229508196721, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=36.3636363636364, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=30.1075268817204, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11529; Mature: 11398

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQVTDATFEQEVLKSDVPVLLDFWAPWCGPCRMVAPILDELSEEFAGRAKIAKVNVDE
CEEEECCCHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NQQIPAQFGIRSIPTLILFKNGEVVATQVGALPKSQLSAFVEQAL
CCCCCHHCCCCCCCEEEEEECCCEEEEHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLQVTDATFEQEVLKSDVPVLLDFWAPWCGPCRMVAPILDELSEEFAGRAKIAKVNVDE
EEEECCCHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NQQIPAQFGIRSIPTLILFKNGEVVATQVGALPKSQLSAFVEQAL
CCCCCHHCCCCCCCEEEEEECCCEEEEHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]