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The map label for this gene is hflK [H]

Identifier: 126208549

GI number: 126208549

Start: 1245823

End: 1247013

Strand: Reverse

Name: hflK [H]

Synonym: APL_1077

Alternate gene names: 126208549

Gene position: 1247013-1245823 (Counterclockwise)

Preceding gene: 126208550

Following gene: 126208548

Centisome position: 54.83

GC content: 46.85

Gene sequence:

>1191_bases
ATGTCGTGGAATGAGTCAGGCAATCAGCAGGATCCGTGGGGTAAACCGGGTCAAAAAAAGCCTGAGCAACAAGGGCAAGG
GTCTCAACAGGAACCTGAAAAACAGAATAATCGCCAAGAGCCGCCGGATTTAGAGGAGGCTTTTAGCTCGCTATTGAAAA
AAATGGGTGGAGGCAATAAGGGCAATAACTCTCGTCACCCGCAAAATTTCGGAAAATTATTCCCGCTTGCCGCAATTTTT
GCCGCCATTGTATGGGGCGCATCCGGTTTTTATACGATTAAAGAAGCGGAACGCGGCGTAGTCACTCGTTTCGGTAAGTT
AAACGATATTGTGATGCCGGGTTTAAACTGGAAACCGACTTTTGTCGATGAAGTGATTCCGGTCAATATCGAACGTGTTT
CCGAGTTAAAAACCAGCGGATCAATGCTGACCCAAGACGAGAATATGGTTCAGGTGGAAATGACCGTTCAATATCGTGTC
GAAGATCCGGCTAAATATCTGTTTAGCGTGCGTGATGCGGACGACAGCTTAAAGCAAGCGACCGACAGTGCGCTACGTTA
TGTCATCGGTCATATGTCGATGGACGATATTTTAACGACAGGTCGTGCGACGGTTCGTGAAAAAACTTGGCAAACTTTGC
GTGATATTATCAAAACCTATGATATGGGTTTATTGGTTACCGACGTAAACTTCCAATCGGCTCGTCCGCCGGAAGAGGTG
AAAGACGCATTCGATGATGCGATTAAAGCGCAAGAAGACGAACAGCGTTTGATCCGTGAAGCGGAGGCTTATGCACGCGG
TCGTGAACCGATTGCGCGCGGTCAGGCACAGCGTATCGTTGAGCAGGCAACTGCCTATAAAGATCAAATTGTATTAGAAG
CAAAAGGTGAAGTTGAGCGTTTTTCTAAACTTTTACCGGAATATAAAGCGGCACCGCAAGTGATGCGTGAACGTTTATAT
ATCGAAACCATGGAAAAAGTGATGAAAAACACGCCGAAAGTGATTATGGACGGCAACGGCAATAACTTAAACGTATTGCC
AATGGATAAATTATTGGCGAAACCGGTTGCTGCCGAACCGGCAAAAACAGCGGCGCCGATTGTTGTTCAGCAACCGCAAG
TGATCCATCAACCGGCGCAAACCGTGCCGACTACACAAAACGAACAACCGGTACGTAAGGGGAGATTTTAA

Upstream 100 bases:

>100_bases
TGTTCTATAAAGCCTAGCAAAATGAGGTACAAATAGGTACAATCCCCAAGTTACGTTATTTTAAATGGGCGTACAGAAAT
TTTTTATTTTGGAGAAATTT

Downstream 100 bases:

>100_bases
TAATGCGTAAATTATTATTACCTATTTTATCTCTGGTTGCTTTTTTAGTGATCTCTTGTATTACGATCGTACCGGAAGGC
TATCGCGGCATTATGTTACG

Product: protein HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSWNESGNQQDPWGKPGQKKPEQQGQGSQQEPEKQNNRQEPPDLEEAFSSLLKKMGGGNKGNNSRHPQNFGKLFPLAAIF
AAIVWGASGFYTIKEAERGVVTRFGKLNDIVMPGLNWKPTFVDEVIPVNIERVSELKTSGSMLTQDENMVQVEMTVQYRV
EDPAKYLFSVRDADDSLKQATDSALRYVIGHMSMDDILTTGRATVREKTWQTLRDIIKTYDMGLLVTDVNFQSARPPEEV
KDAFDDAIKAQEDEQRLIREAEAYARGREPIARGQAQRIVEQATAYKDQIVLEAKGEVERFSKLLPEYKAAPQVMRERLY
IETMEKVMKNTPKVIMDGNGNNLNVLPMDKLLAKPVAAEPAKTAAPIVVQQPQVIHQPAQTVPTTQNEQPVRKGRF

Sequences:

>Translated_396_residues
MSWNESGNQQDPWGKPGQKKPEQQGQGSQQEPEKQNNRQEPPDLEEAFSSLLKKMGGGNKGNNSRHPQNFGKLFPLAAIF
AAIVWGASGFYTIKEAERGVVTRFGKLNDIVMPGLNWKPTFVDEVIPVNIERVSELKTSGSMLTQDENMVQVEMTVQYRV
EDPAKYLFSVRDADDSLKQATDSALRYVIGHMSMDDILTTGRATVREKTWQTLRDIIKTYDMGLLVTDVNFQSARPPEEV
KDAFDDAIKAQEDEQRLIREAEAYARGREPIARGQAQRIVEQATAYKDQIVLEAKGEVERFSKLLPEYKAAPQVMRERLY
IETMEKVMKNTPKVIMDGNGNNLNVLPMDKLLAKPVAAEPAKTAAPIVVQQPQVIHQPAQTVPTTQNEQPVRKGRF
>Mature_395_residues
SWNESGNQQDPWGKPGQKKPEQQGQGSQQEPEKQNNRQEPPDLEEAFSSLLKKMGGGNKGNNSRHPQNFGKLFPLAAIFA
AIVWGASGFYTIKEAERGVVTRFGKLNDIVMPGLNWKPTFVDEVIPVNIERVSELKTSGSMLTQDENMVQVEMTVQYRVE
DPAKYLFSVRDADDSLKQATDSALRYVIGHMSMDDILTTGRATVREKTWQTLRDIIKTYDMGLLVTDVNFQSARPPEEVK
DAFDDAIKAQEDEQRLIREAEAYARGREPIARGQAQRIVEQATAYKDQIVLEAKGEVERFSKLLPEYKAAPQVMRERLYI
ETMEKVMKNTPKVIMDGNGNNLNVLPMDKLLAKPVAAEPAKTAAPIVVQQPQVIHQPAQTVPTTQNEQPVRKGRF

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=365, Percent_Identity=58.0821917808219, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: NA

Molecular weight: Translated: 44540; Mature: 44409

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWNESGNQQDPWGKPGQKKPEQQGQGSQQEPEKQNNRQEPPDLEEAFSSLLKKMGGGNK
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GNNSRHPQNFGKLFPLAAIFAAIVWGASGFYTIKEAERGVVTRFGKLNDIVMPGLNWKPT
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHCCCCCEECCCCCCCCC
FVDEVIPVNIERVSELKTSGSMLTQDENMVQVEMTVQYRVEDPAKYLFSVRDADDSLKQA
HHHHHCCCCHHHHHHHHHCCCCEECCCCEEEEEEEEEEEECCHHHHHHHHHCCHHHHHHH
TDSALRYVIGHMSMDDILTTGRATVREKTWQTLRDIIKTYDMGLLVTDVNFQSARPPEEV
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHH
KDAFDDAIKAQEDEQRLIREAEAYARGREPIARGQAQRIVEQATAYKDQIVLEAKGEVER
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHH
FSKLLPEYKAAPQVMRERLYIETMEKVMKNTPKVIMDGNGNNLNVLPMDKLLAKPVAAEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEHHHHHHCCCCCCC
AKTAAPIVVQQPQVIHQPAQTVPTTQNEQPVRKGRF
CCCCCCEEECCCHHHHCCHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SWNESGNQQDPWGKPGQKKPEQQGQGSQQEPEKQNNRQEPPDLEEAFSSLLKKMGGGNK
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GNNSRHPQNFGKLFPLAAIFAAIVWGASGFYTIKEAERGVVTRFGKLNDIVMPGLNWKPT
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHCCCCCEECCCCCCCCC
FVDEVIPVNIERVSELKTSGSMLTQDENMVQVEMTVQYRVEDPAKYLFSVRDADDSLKQA
HHHHHCCCCHHHHHHHHHCCCCEECCCCEEEEEEEEEEEECCHHHHHHHHHCCHHHHHHH
TDSALRYVIGHMSMDDILTTGRATVREKTWQTLRDIIKTYDMGLLVTDVNFQSARPPEEV
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHH
KDAFDDAIKAQEDEQRLIREAEAYARGREPIARGQAQRIVEQATAYKDQIVLEAKGEVER
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHH
FSKLLPEYKAAPQVMRERLYIETMEKVMKNTPKVIMDGNGNNLNVLPMDKLLAKPVAAEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEHHHHHHCCCCCCC
AKTAAPIVVQQPQVIHQPAQTVPTTQNEQPVRKGRF
CCCCCCEEECCCHHHHCCHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]