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The map label for this gene is cpx [H]

Identifier: 126208551

GI number: 126208551

Start: 1247641

End: 1248933

Strand: Reverse

Name: cpx [H]

Synonym: APL_1079

Alternate gene names: 126208551

Gene position: 1248933-1247641 (Counterclockwise)

Preceding gene: 126208552

Following gene: 126208550

Centisome position: 54.91

GC content: 47.18

Gene sequence:

>1293_bases
ATGCAAAATTTACGTTATCCCGTTGATTCCAAACCGCCTTTCGGCTTAACCCTTCTTTTAGCGGCACAACATCTGTTGGC
TGCGCTCGGCGGTATTATCGCCGTTCCGCTTGTTATCGGTAATGTGTTAAAACTTCCGACTCCCGATACGATTGTATTGG
TTAATGCGGCGTTATTGGTGTCCGGTATTGTGACGATTATTCAATGCCAAGGTATCGGTCCTATCGGTTTGCGCTTACCG
AGTGTGATGGGAACCAGCTTTACTTTCGTGGCGGCGGCGCTTGCGATCGGTTTTAGCGAACACGGCGTTGCCGGTATTAT
GGGAGCCTCATTAGTCGGTTCGTTAGTGATGATTATCGGCAGTTTCTTTATGCCGTATGTACGTAAATTATTCCCGCCTG
TGGTGACAGGTGTCGTAGTGATGATGATCGGCTTGAGCTTAATTCCGGTTGCGGTGGACTGGTTCGCCGGCGGTCAAAAA
GGTGACCCGCATTATGCGGATCCGGCAAACCTTGCGATGGCGACTTTTGTACTTGTGCTGGTTGTGATCTTAGTGCAATG
GGGTAAAGGTATTTTCTCGGCGGCGGCAATCGTAATCGGGATGATGGTCGGTTATGTAGTGGCGTTAGCATTAGGTTGGA
TTAACTTTGATGCGGTCAAAAACGCCGATGCGTTTGCGATTCCGCAGCCGTTGCATTTCGGTTTAGCCTTCCCGATTTCA
GGGATTATCGGGATGTCGATTGCTTATTTGGTGACGATTGTCGAATCAAGCGGTAACTTCTTAGCATTAGGTAATGCAAC
GCAAACGGAAATTACCGGTAAGCATTTACGTGGCGGCGTGTTATGTGACGGTTTAGGTTCGGCGTTTGCGGCAATTATGT
CCACTACACCGTTCTCGTCATTTGCGCAAAATATCGGAGTGATTTCCCTAACCGGCGTAGCAAGTCGCTATGTAGTAACG
ATTATGGGCGTATTATTGGTATTAGCCGGCGTATTCCCGTGGTTCGGTGCGTTAATCGTTTCGATTCCTAGTCCTGTGTT
AGGCGGTGCGGGTTTAATGATGTTTGCGATGATTATTGCCGCCGGTATTCAAATGTTGGATAAAGTGGAGCGTTCAAAAC
GTAACGGTTTAATTATTGCGATTTCAATCGGTTGCGGTTTAGCGGTAACCACTCGTCCCGAATTATTGGATAAATTACCG
GGCTTCTTTAAAGAAGTGTTCGGTTCGGGTATTACGGTCGGCTCTTTACTGGCATTAATCCTCAATTTAATTTTGCCTGA
AGATAAAGAATAG

Upstream 100 bases:

>100_bases
TCAACCGCTTATTTTTTAACTGTTCATTGTGGCGCAAACGTTTGCGCAATGGGGTGTAAAAGCGTATAATTCGCCCCAAT
TTTTTTAATTTGAGGCATTT

Downstream 100 bases:

>100_bases
AGATTAAAATAAATAATCGAAGTAATCGGGAAAACTTACTTGAAATTGAGTAAACGAACCCTTATCTTACGGTGTAACTT
AACGCCACGGTCAAGTGGCG

Product: putative purine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MQNLRYPVDSKPPFGLTLLLAAQHLLAALGGIIAVPLVIGNVLKLPTPDTIVLVNAALLVSGIVTIIQCQGIGPIGLRLP
SVMGTSFTFVAAALAIGFSEHGVAGIMGASLVGSLVMIIGSFFMPYVRKLFPPVVTGVVVMMIGLSLIPVAVDWFAGGQK
GDPHYADPANLAMATFVLVLVVILVQWGKGIFSAAAIVIGMMVGYVVALALGWINFDAVKNADAFAIPQPLHFGLAFPIS
GIIGMSIAYLVTIVESSGNFLALGNATQTEITGKHLRGGVLCDGLGSAFAAIMSTTPFSSFAQNIGVISLTGVASRYVVT
IMGVLLVLAGVFPWFGALIVSIPSPVLGGAGLMMFAMIIAAGIQMLDKVERSKRNGLIIAISIGCGLAVTTRPELLDKLP
GFFKEVFGSGITVGSLLALILNLILPEDKE

Sequences:

>Translated_430_residues
MQNLRYPVDSKPPFGLTLLLAAQHLLAALGGIIAVPLVIGNVLKLPTPDTIVLVNAALLVSGIVTIIQCQGIGPIGLRLP
SVMGTSFTFVAAALAIGFSEHGVAGIMGASLVGSLVMIIGSFFMPYVRKLFPPVVTGVVVMMIGLSLIPVAVDWFAGGQK
GDPHYADPANLAMATFVLVLVVILVQWGKGIFSAAAIVIGMMVGYVVALALGWINFDAVKNADAFAIPQPLHFGLAFPIS
GIIGMSIAYLVTIVESSGNFLALGNATQTEITGKHLRGGVLCDGLGSAFAAIMSTTPFSSFAQNIGVISLTGVASRYVVT
IMGVLLVLAGVFPWFGALIVSIPSPVLGGAGLMMFAMIIAAGIQMLDKVERSKRNGLIIAISIGCGLAVTTRPELLDKLP
GFFKEVFGSGITVGSLLALILNLILPEDKE
>Mature_430_residues
MQNLRYPVDSKPPFGLTLLLAAQHLLAALGGIIAVPLVIGNVLKLPTPDTIVLVNAALLVSGIVTIIQCQGIGPIGLRLP
SVMGTSFTFVAAALAIGFSEHGVAGIMGASLVGSLVMIIGSFFMPYVRKLFPPVVTGVVVMMIGLSLIPVAVDWFAGGQK
GDPHYADPANLAMATFVLVLVVILVQWGKGIFSAAAIVIGMMVGYVVALALGWINFDAVKNADAFAIPQPLHFGLAFPIS
GIIGMSIAYLVTIVESSGNFLALGNATQTEITGKHLRGGVLCDGLGSAFAAIMSTTPFSSFAQNIGVISLTGVASRYVVT
IMGVLLVLAGVFPWFGALIVSIPSPVLGGAGLMMFAMIIAAGIQMLDKVERSKRNGLIIAISIGCGLAVTTRPELLDKLP
GFFKEVFGSGITVGSLLALILNLILPEDKE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=504, Percent_Identity=25.5952380952381, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI44680148, Length=471, Percent_Identity=25.2653927813163, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI40316845, Length=471, Percent_Identity=25.2653927813163, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI44680143, Length=508, Percent_Identity=25.5905511811024, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI87082181, Length=415, Percent_Identity=36.3855421686747, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1790087, Length=443, Percent_Identity=36.117381489842, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87082178, Length=439, Percent_Identity=35.7630979498861, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1788843, Length=380, Percent_Identity=27.3684210526316, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87081818, Length=394, Percent_Identity=28.6802030456853, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17541904, Length=484, Percent_Identity=22.7272727272727, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993493, Length=483, Percent_Identity=24.8447204968944, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17542262, Length=490, Percent_Identity=23.265306122449, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=475, Percent_Identity=23.3684210526316, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=220, Percent_Identity=28.1818181818182, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356175, Length=502, Percent_Identity=25.8964143426295, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44567; Mature: 44567

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCC
>Mature Secondary Structure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HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]