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The map label for this gene is galK

Identifier: 126208469

GI number: 126208469

Start: 1150505

End: 1151659

Strand: Direct

Name: galK

Synonym: APL_0995

Alternate gene names: 126208469

Gene position: 1150505-1151659 (Clockwise)

Preceding gene: 126208468

Following gene: 126208470

Centisome position: 50.58

GC content: 46.15

Gene sequence:

>1155_bases
ATGAAACCACAACAGCTTGCGACACAAAAATTTAGCGAACATTACGGCTACTCGGCAGCTCAAACCGTATTTGCTCCGGG
GCGGGTCAATATTATCGGCGAACATACCGATTATAACGACGGCTTCGTAATGCCGTGTGCGATTAACTACGGAATGGCGG
TCAGCTTTAGTAAACGTGACGATTCGGTTTGGCGAGTGTATGCGATTGATATTGATGAACAAGATGAGTTTGACCTTAGC
CGACCGATTGAACCGTCCGAACACAAATGGGCGAATTACGTACGCGGCGTGGTGAAATATATTCAAGAAAAATGTCCGGA
GTTTAAACAAGGTGCGGATTTAGCGATGACCAGCGACGTGCCGATGTCTTCCGGTTTAAGTTCGTCCGCCGCATTAGAAA
TTTCAATCGGTAAAACTGCGCAAGTGCTAGGCGATTTACCACTCGGTTTGGCGGAAATCGCCTTGATCGGACAACAAGCC
GAGAATAAATTCGTCGGCGCAAATTGCGGCAATATGGATCAACTTACCTCTGCGCTCGGACAAAAAGATCAAGTGATTAT
GATTGATTGCCGTTCGTTAGAAATTACCCCGACACCGGTTCCGCACGGCTATTCGATTGCGATTATCAACTCTAACGTGA
AACACGATTTAGTCACCGGTGAATACAACAGTCGCCGTCAAGAGTGTGAATTTGCCGCACGATTCTTCGGTGTGAAAGCA
TTACGTGATGTTACACCGGAACAATTTATCGAGCGAGCGGCAGAGTTACAAGCCGAAAATGAACTTGCCTATAAACGTGC
GAAACATATCATCAGTGAAAATCAGCGTGTATTAGAAGCGGTTGAAGCCTTAAAAGCGAATGATATGGTCAAACTCGGTC
AATTAATGGCGGGGTCGCATGATTCTATGCGTGACGATTTTGAAATTACTATTCCGGAAATCGACTACTTGGTCGAACTG
GCACAAATAGCAATCGGTAAAAACGGCGGCGCACGTATGACCGGCGGCGGTTTCGGCGGCTGTATCGTTTGCTTGGTACC
GGATGGAAAAGTGGAACATTTACGCCGAATCATTGCGGATAACTATGAAAAACAGACCGGTATCAAAGAAACTTTCCACC
TTTGTACCGCTTGTGATGGCGTTCATCTTATTTAA

Upstream 100 bases:

>100_bases
AGATCTGACACCGGAACAAGCGGCGGAAAGATTAAATGCTGTGAGCGACAGCGTTCACTATAAAAATCAATAGAAAGAAA
TAGCGAGAGAGAAAGATAGA

Downstream 100 bases:

>100_bases
TCGTTCATCTGCAGAAATCACGGAAATTTCCGTGATTTCTTGCTTTCGGAGCAAGTTATGAAAACCTTTACCCTAGAAAA
CTCATTTCTTAAAATTACGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRDDSVWRVYAIDIDEQDEFDLS
RPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDVPMSSGLSSSAALEISIGKTAQVLGDLPLGLAEIALIGQQA
ENKFVGANCGNMDQLTSALGQKDQVIMIDCRSLEITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKA
LRDVTPEQFIERAAELQAENELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSHDSMRDDFEITIPEIDYLVEL
AQIAIGKNGGARMTGGGFGGCIVCLVPDGKVEHLRRIIADNYEKQTGIKETFHLCTACDGVHLI

Sequences:

>Translated_384_residues
MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRDDSVWRVYAIDIDEQDEFDLS
RPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDVPMSSGLSSSAALEISIGKTAQVLGDLPLGLAEIALIGQQA
ENKFVGANCGNMDQLTSALGQKDQVIMIDCRSLEITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKA
LRDVTPEQFIERAAELQAENELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSHDSMRDDFEITIPEIDYLVEL
AQIAIGKNGGARMTGGGFGGCIVCLVPDGKVEHLRRIIADNYEKQTGIKETFHLCTACDGVHLI
>Mature_384_residues
MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRDDSVWRVYAIDIDEQDEFDLS
RPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDVPMSSGLSSSAALEISIGKTAQVLGDLPLGLAEIALIGQQA
ENKFVGANCGNMDQLTSALGQKDQVIMIDCRSLEITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKA
LRDVTPEQFIERAAELQAENELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSHDSMRDDFEITIPEIDYLVEL
AQIAIGKNGGARMTGGGFGGCIVCLVPDGKVEHLRRIIADNYEKQTGIKETFHLCTACDGVHLI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=387, Percent_Identity=39.7932816537468, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI48527957, Length=406, Percent_Identity=30.5418719211823, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4503897, Length=406, Percent_Identity=30.5418719211823, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1786972, Length=372, Percent_Identity=54.0322580645161, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71989053, Length=412, Percent_Identity=25.9708737864078, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=30.7053941908714, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319494, Length=257, Percent_Identity=30.7392996108949, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24661292, Length=433, Percent_Identity=27.9445727482679, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355577, Length=433, Percent_Identity=27.9445727482679, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24661285, Length=433, Percent_Identity=27.9445727482679, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_ACTP2 (A3N103)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053694.1
- ProteinModelPortal:   A3N103
- SMR:   A3N103
- STRING:   A3N103
- GeneID:   4848693
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0995
- eggNOG:   COG0153
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- PhylomeDB:   A3N103
- ProtClustDB:   PRK05101
- BioCyc:   APLE416269:APL_0995-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 42299; Mature: 42299

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRD
CCCHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCC
DSVWRVYAIDIDEQDEFDLSRPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDV
CCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCC
PMSSGLSSSAALEISIGKTAQVLGDLPLGLAEIALIGQQAENKFVGANCGNMDQLTSALG
CCCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHC
QKDQVIMIDCRSLEITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKA
CCCCEEEEEECCEEECCCCCCCCEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHH
LRDVTPEQFIERAAELQAENELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCC
DSMRDDFEITIPEIDYLVELAQIAIGKNGGARMTGGGFGGCIVCLVPDGKVEHLRRIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHC
NYEKQTGIKETFHLCTACDGVHLI
CCHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPQQLATQKFSEHYGYSAAQTVFAPGRVNIIGEHTDYNDGFVMPCAINYGMAVSFSKRD
CCCHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCC
DSVWRVYAIDIDEQDEFDLSRPIEPSEHKWANYVRGVVKYIQEKCPEFKQGADLAMTSDV
CCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCC
PMSSGLSSSAALEISIGKTAQVLGDLPLGLAEIALIGQQAENKFVGANCGNMDQLTSALG
CCCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHC
QKDQVIMIDCRSLEITPTPVPHGYSIAIINSNVKHDLVTGEYNSRRQECEFAARFFGVKA
CCCCEEEEEECCEEECCCCCCCCEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHH
LRDVTPEQFIERAAELQAENELAYKRAKHIISENQRVLEAVEALKANDMVKLGQLMAGSH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCC
DSMRDDFEITIPEIDYLVELAQIAIGKNGGARMTGGGFGGCIVCLVPDGKVEHLRRIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHC
NYEKQTGIKETFHLCTACDGVHLI
CCHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA