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The map label for this gene is galM [H]

Identifier: 126208470

GI number: 126208470

Start: 1151717

End: 1152685

Strand: Direct

Name: galM [H]

Synonym: APL_0996

Alternate gene names: 126208470

Gene position: 1151717-1152685 (Clockwise)

Preceding gene: 126208469

Following gene: 126208471

Centisome position: 50.64

GC content: 44.58

Gene sequence:

>969_bases
ATGAAAACCTTTACCCTAGAAAACTCATTTCTTAAAATTACGTTATCCGACTTCGGTGCCGCTTGGCTTTCTTGTGTGGT
GAAACACCCGAAAGGCGAACGTGAAGTGTTAGTTACGACTTCTGCAGAAAATTGGCAAAATCAGACCGCTTACTTTGGAG
CAACTTGCGGACGTTATGCCAACCGTATCGCTAATGCCGAATATCAGCTTAACGGCAAAACCTATACTTTGGTTAAAAAT
GACGGTAAAAACACTTTACACGGCGGTGCTAACGGGGCGGATAAACAAATTTGGCAAGCGGAGCAGCTTGATCCGCAAGC
GGTCAAATTCAGCCGAATTTTTGCAGACGGCGAACAAGGTTTCGGCGGTGAAGTGAATGCCGTTGTGACTTATCGTTTGA
ATGGAAAAGAAGTCGAAATTGAATTTGAAGCAACCGCCAATCAAGATACCCCGCTCTGTTTTACCAATCACGCTTATTTC
AATTTACTCGGCGCAGGTGATGTGCTTTCGCATCAATTGATGATTAACGCAGACGAATATTTACCGGTCGGTGCAGACGG
TATCCCGATTTTACCGTTTAAAGCGGTTGCTCACACCGGTTTTGATTTTTCAACGCCTAAACTTATCGGGCAAGACTTGC
TGAAAGATACCGATCAACAGCTGGTAAAAGGCTACGATCACGCTTTCAAATTGGTAAAAAACTCTGCAAAACCGACCGCT
TGTTTAACGGTTGAAGATCTTGCACTTGAACTCAATACCTCAATGCCGGCACTACAATGCTATTCGGGAAATTGGCTTGG
CGGGCAACCAAATCTGAGCGGTTCAACTTATCAAGATTACGCCGGTGTTGCTTTAGAACCGGAGTTTTTCCCCGATTCGC
CAAACCAAGCCGAACTGGCAAAATTTGGTGGCATTACCAAAGCAGGCGAACGCTATAAACACGATATTCGTTACACCTTT
CACTTTTAA

Upstream 100 bases:

>100_bases
TTTCCACCTTTGTACCGCTTGTGATGGCGTTCATCTTATTTAATCGTTCATCTGCAGAAATCACGGAAATTTCCGTGATT
TCTTGCTTTCGGAGCAAGTT

Downstream 100 bases:

>100_bases
TTTGTAAACATCGAGGAAATTATCATGATACTGCCGAATTACTTCCAAGATCCCAATACGCTCCACGTAAATACCGTTGA
GCATCACGCTTATTTTATTC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKTFTLENSFLKITLSDFGAAWLSCVVKHPKGEREVLVTTSAENWQNQTAYFGATCGRYANRIANAEYQLNGKTYTLVKN
DGKNTLHGGANGADKQIWQAEQLDPQAVKFSRIFADGEQGFGGEVNAVVTYRLNGKEVEIEFEATANQDTPLCFTNHAYF
NLLGAGDVLSHQLMINADEYLPVGADGIPILPFKAVAHTGFDFSTPKLIGQDLLKDTDQQLVKGYDHAFKLVKNSAKPTA
CLTVEDLALELNTSMPALQCYSGNWLGGQPNLSGSTYQDYAGVALEPEFFPDSPNQAELAKFGGITKAGERYKHDIRYTF
HF

Sequences:

>Translated_322_residues
MKTFTLENSFLKITLSDFGAAWLSCVVKHPKGEREVLVTTSAENWQNQTAYFGATCGRYANRIANAEYQLNGKTYTLVKN
DGKNTLHGGANGADKQIWQAEQLDPQAVKFSRIFADGEQGFGGEVNAVVTYRLNGKEVEIEFEATANQDTPLCFTNHAYF
NLLGAGDVLSHQLMINADEYLPVGADGIPILPFKAVAHTGFDFSTPKLIGQDLLKDTDQQLVKGYDHAFKLVKNSAKPTA
CLTVEDLALELNTSMPALQCYSGNWLGGQPNLSGSTYQDYAGVALEPEFFPDSPNQAELAKFGGITKAGERYKHDIRYTF
HF
>Mature_322_residues
MKTFTLENSFLKITLSDFGAAWLSCVVKHPKGEREVLVTTSAENWQNQTAYFGATCGRYANRIANAEYQLNGKTYTLVKN
DGKNTLHGGANGADKQIWQAEQLDPQAVKFSRIFADGEQGFGGEVNAVVTYRLNGKEVEIEFEATANQDTPLCFTNHAYF
NLLGAGDVLSHQLMINADEYLPVGADGIPILPFKAVAHTGFDFSTPKLIGQDLLKDTDQQLVKGYDHAFKLVKNSAKPTA
CLTVEDLALELNTSMPALQCYSGNWLGGQPNLSGSTYQDYAGVALEPEFFPDSPNQAELAKFGGITKAGERYKHDIRYTF
HF

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=329, Percent_Identity=36.1702127659575, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1786971, Length=328, Percent_Identity=44.5121951219512, Blast_Score=247, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17557428, Length=318, Percent_Identity=31.4465408805031, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI115533334, Length=318, Percent_Identity=31.4465408805031, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319493, Length=328, Percent_Identity=26.219512195122, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324399, Length=341, Percent_Identity=23.7536656891496, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322004, Length=343, Percent_Identity=25.9475218658892, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668278, Length=341, Percent_Identity=30.4985337243402, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24659048, Length=344, Percent_Identity=30.5232558139535, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24583720, Length=338, Percent_Identity=29.585798816568, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24641876, Length=290, Percent_Identity=28.9655172413793, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24668282, Length=302, Percent_Identity=28.1456953642384, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 35416; Mature: 35416

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFTLENSFLKITLSDFGAAWLSCVVKHPKGEREVLVTTSAENWQNQTAYFGATCGRYA
CCEEEECCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECCHHHHHH
NRIANAEYQLNGKTYTLVKNDGKNTLHGGANGADKQIWQAEQLDPQAVKFSRIFADGEQG
HHHCCCEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHEEEEEEEECCCCC
FGGEVNAVVTYRLNGKEVEIEFEATANQDTPLCFTNHAYFNLLGAGDVLSHQLMINADEY
CCCCEEEEEEEEECCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCHHCEEEEEECCCC
LPVGADGIPILPFKAVAHTGFDFSTPKLIGQDLLKDTDQQLVKGYDHAFKLVKNSAKPTA
CCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CLTVEDLALELNTSMPALQCYSGNWLGGQPNLSGSTYQDYAGVALEPEFFPDSPNQAELA
EEEEEHEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHH
KFGGITKAGERYKHDIRYTFHF
HHCCCCCCCHHHCEEEEEEEEC
>Mature Secondary Structure
MKTFTLENSFLKITLSDFGAAWLSCVVKHPKGEREVLVTTSAENWQNQTAYFGATCGRYA
CCEEEECCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECCHHHHHH
NRIANAEYQLNGKTYTLVKNDGKNTLHGGANGADKQIWQAEQLDPQAVKFSRIFADGEQG
HHHCCCEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHEEEEEEEECCCCC
FGGEVNAVVTYRLNGKEVEIEFEATANQDTPLCFTNHAYFNLLGAGDVLSHQLMINADEY
CCCCEEEEEEEEECCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCHHCEEEEEECCCC
LPVGADGIPILPFKAVAHTGFDFSTPKLIGQDLLKDTDQQLVKGYDHAFKLVKNSAKPTA
CCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CLTVEDLALELNTSMPALQCYSGNWLGGQPNLSGSTYQDYAGVALEPEFFPDSPNQAELA
EEEEEHEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHH
KFGGITKAGERYKHDIRYTFHF
HHCCCCCCCHHHCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 1282642 [H]