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The map label for this gene is holA [H]

Identifier: 126208350

GI number: 126208350

Start: 1015440

End: 1016465

Strand: Direct

Name: holA [H]

Synonym: APL_0874

Alternate gene names: 126208350

Gene position: 1015440-1016465 (Clockwise)

Preceding gene: 126208349

Following gene: 126208357

Centisome position: 44.64

GC content: 41.03

Gene sequence:

>1026_bases
ATGCAAAAAGTTTTCCCTGAAGCACTTCCTAACCTTTTATCTAAAAGCCTCTCCCCTTTCTATCTACTGACAGGCAACGA
TCTTCTACTGATTAACGAAAGTAAAGATCACATCGTGCAAGCCGCTCGTTTAGCGGATTTCGATGAGAAACAAGAAGTCA
GTATTGCAAATGACACAAAATGGGAAGCTCTGTTTGAGGCAGCACAATCAAACGGTTTGTTCTTTAATCGCCAAATTATT
ATTCTCAACCTGCCAGAAGCGCCAACTGCAGCACAAATGAAAAATGTTGCGGAGTTATGCCGTTTTAGCCATCCGGATCT
ATTGTTGATTCTCTGCTTACCAAAATTCAGTAAGGCAATGGAAAAGCAAGCATGGTTCACACAAATCGGAGCACAAACCG
TACAAATCAATTGCCAAACGCCGGAAATGGCTAAATTACCGACTTGGATCTCACATAGAGCCAAAGCTATGGAATTGCAG
ATTGAGCCGGAAGCCATTCAGTTGCTCTGTTATAGCTATGAAGGAAATTTATTAGCGCTAAAACAAGCGTTACAGATGCT
GCAACTCCGCTTTAACGACGGAAAAATTTCACTGGCTCGCGCTAAAGAAGTGGTGGAACAATCCGCTCAATTTTCACCAT
TTCAATGGATTGATGCGTTATTAGAAGGCAAAATTGCTCGTGCGGAACGTATTTTAAAACATCTACAAAACGAAGAAGTT
CAACCGGTTGTCTTGTTACGTATTATTCAAAAAGAGCTACTGGTGCTACTGGAAATTACTCGTTCTCCGCAACCGGTGCA
AAATAGCAATCAGCCGTTATATATGGGTAATTTACGTGCGGAATTCGACCGCTTGAAGGTCTGGCAAAATCGCCGTCCTT
TTTATCAAGCCGCAGTACAACGCTTAACGTATAAAAAATTGTATCAACTTATTCAACGCTTAGCGGAATTGGAAAAGCAA
GTAAAACAAGAATTTAGTGATGAGATTTGGCTGGAATTAGAACGCTTTTCCGCCTATTTTGAATAG

Upstream 100 bases:

>100_bases
CCACAGATAACACGGATTTCACGCAAACAAGCGGTTAAATTCTTGCACTTTTTTGCAAGCGGGCAATCCGTGTTTATCCG
TGTAATCCGTGGTTTTTAAT

Downstream 100 bases:

>100_bases
AGAAATAAAAACGGAAGCTGTTACAAGCGGTTAAATTTTATGATAAATTTGCAATAGCTTCCGTCATAGTTATTGGTTAG
TAATGCCCTTCTAAATCCGA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQKVFPEALPNLLSKSLSPFYLLTGNDLLLINESKDHIVQAARLADFDEKQEVSIANDTKWEALFEAAQSNGLFFNRQII
ILNLPEAPTAAQMKNVAELCRFSHPDLLLILCLPKFSKAMEKQAWFTQIGAQTVQINCQTPEMAKLPTWISHRAKAMELQ
IEPEAIQLLCYSYEGNLLALKQALQMLQLRFNDGKISLARAKEVVEQSAQFSPFQWIDALLEGKIARAERILKHLQNEEV
QPVVLLRIIQKELLVLLEITRSPQPVQNSNQPLYMGNLRAEFDRLKVWQNRRPFYQAAVQRLTYKKLYQLIQRLAELEKQ
VKQEFSDEIWLELERFSAYFE

Sequences:

>Translated_341_residues
MQKVFPEALPNLLSKSLSPFYLLTGNDLLLINESKDHIVQAARLADFDEKQEVSIANDTKWEALFEAAQSNGLFFNRQII
ILNLPEAPTAAQMKNVAELCRFSHPDLLLILCLPKFSKAMEKQAWFTQIGAQTVQINCQTPEMAKLPTWISHRAKAMELQ
IEPEAIQLLCYSYEGNLLALKQALQMLQLRFNDGKISLARAKEVVEQSAQFSPFQWIDALLEGKIARAERILKHLQNEEV
QPVVLLRIIQKELLVLLEITRSPQPVQNSNQPLYMGNLRAEFDRLKVWQNRRPFYQAAVQRLTYKKLYQLIQRLAELEKQ
VKQEFSDEIWLELERFSAYFE
>Mature_341_residues
MQKVFPEALPNLLSKSLSPFYLLTGNDLLLINESKDHIVQAARLADFDEKQEVSIANDTKWEALFEAAQSNGLFFNRQII
ILNLPEAPTAAQMKNVAELCRFSHPDLLLILCLPKFSKAMEKQAWFTQIGAQTVQINCQTPEMAKLPTWISHRAKAMELQ
IEPEAIQLLCYSYEGNLLALKQALQMLQLRFNDGKISLARAKEVVEQSAQFSPFQWIDALLEGKIARAERILKHLQNEEV
QPVVLLRIIQKELLVLLEITRSPQPVQNSNQPLYMGNLRAEFDRLKVWQNRRPFYQAAVQRLTYKKLYQLIQRLAELEKQ
VKQEFSDEIWLELERFSAYFE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=338, Percent_Identity=44.3786982248521, Blast_Score=258, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39500; Mature: 39500

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVFPEALPNLLSKSLSPFYLLTGNDLLLINESKDHIVQAARLADFDEKQEVSIANDTK
CCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCH
WEALFEAAQSNGLFFNRQIIILNLPEAPTAAQMKNVAELCRFSHPDLLLILCLPKFSKAM
HHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
EKQAWFTQIGAQTVQINCQTPEMAKLPTWISHRAKAMELQIEPEAIQLLCYSYEGNLLAL
HHHHHHHHHCCEEEEEEECCCCHHHCCHHHHCCCHHEEEEECHHHHEEEEEECCCCCHHH
KQALQMLQLRFNDGKISLARAKEVVEQSAQFSPFQWIDALLEGKIARAERILKHLQNEEV
HHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCC
QPVVLLRIIQKELLVLLEITRSPQPVQNSNQPLYMGNLRAEFDRLKVWQNRRPFYQAAVQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHH
RLTYKKLYQLIQRLAELEKQVKQEFSDEIWLELERFSAYFE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKVFPEALPNLLSKSLSPFYLLTGNDLLLINESKDHIVQAARLADFDEKQEVSIANDTK
CCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCH
WEALFEAAQSNGLFFNRQIIILNLPEAPTAAQMKNVAELCRFSHPDLLLILCLPKFSKAM
HHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
EKQAWFTQIGAQTVQINCQTPEMAKLPTWISHRAKAMELQIEPEAIQLLCYSYEGNLLAL
HHHHHHHHHCCEEEEEEECCCCHHHCCHHHHCCCHHEEEEECHHHHEEEEEECCCCCHHH
KQALQMLQLRFNDGKISLARAKEVVEQSAQFSPFQWIDALLEGKIARAERILKHLQNEEV
HHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCC
QPVVLLRIIQKELLVLLEITRSPQPVQNSNQPLYMGNLRAEFDRLKVWQNRRPFYQAAVQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHH
RLTYKKLYQLIQRLAELEKQVKQEFSDEIWLELERFSAYFE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]