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The map label for this gene is sucD [H]

Identifier: 126207935

GI number: 126207935

Start: 519366

End: 520238

Strand: Reverse

Name: sucD [H]

Synonym: APL_0451

Alternate gene names: 126207935

Gene position: 520238-519366 (Counterclockwise)

Preceding gene: 126207936

Following gene: 126207932

Centisome position: 22.87

GC content: 45.59

Gene sequence:

>873_bases
ATGGCGATTTTAATTGATAAGAATACTAAAGTGATTTGCCAAGGTTTTACCGGCGGACAAGGCACATTTCATAGCGAACA
GGCTTTAGCATACGGTACGAAACTTGTCGGCGGCGTTTCGCCGAACAAAGGCGGTACAACGCATTTAGGTTTACCGGTAT
TTGATACCGTACGTGAAGCGGTCGAAAAAACCGGTGCGACTGCAAGTGTAATTTACGTTCCCGCTCCTGGCTGTAAAGAT
GCGATTTTGGAAGCGATTGATGCAGGTATCCAGCTTATCGTTTGTATTACCGAAGGTATTCCTACGTTAGATATGATTTG
TGTCAAACAGAAATTAAAAGAAAGCGGTGTACGAATGATTGGTCCGAACTGTCCGGGAATCATTACCCCTGACGAGTGTA
AAATCGGCATTATGCCGGCGCATATTCATAAGAAAGGTAAAATCGGTATTGTTTCTCGTTCCGGCACGCTTACTTATGAA
GCGGTAAAACAAACCACGGATGAAGGATTCGGGCAATCTACCTGTGTCGGTATCGGTGGTGATCCGATTCCAGGCTCAAG
TTTTATCGACATCTTGAAACTCTTCCAAGCCGACCCTGAAACCGAAGCGATCGTAATGATTGGTGAAATCGGAGGTAGCG
CCGAAGAAGAAGCGGCCGAATTTATCAAAATGCACGTAACAAAGCCTGTTGTCAGTTATATCGCCGGCGTTACCGCACCG
AAAGGAAAACGAATGGGACACGCAGGTGCAATCATTAGCGGCGGTAAAGGCACGGCAGATGAAAAATTTAAAACATTAGA
GAATGCCGGCGTGAAAACGGTGAGAAGTCTTGCCGAAATCGGTAGCGCATTAAGAGAATTGCTGCACAAATAA

Upstream 100 bases:

>100_bases
GTCGTGAAATTTTAGCAAACAGCGGCTTACGTCTCATTGCGGCAAATACATTAACACAAGCGGCACAACTTGCAGTCAAA
GCAGCGGAAGGAAAATAAAC

Downstream 100 bases:

>100_bases
ATCTCGTTCAATAATCGGTCGTTTTTTCATAATGATTTGCAAAAATGATAAGATGACCGCAATTGAGTTCAAACGAAAGG
ACTGAGTTGCGATAAATATC

Product: succinyl-CoA ligase [ADP-forming] subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTKLVGGVSPNKGGTTHLGLPVFDTVREAVEKTGATASVIYVPAPGCKD
AILEAIDAGIQLIVCITEGIPTLDMICVKQKLKESGVRMIGPNCPGIITPDECKIGIMPAHIHKKGKIGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSSFIDILKLFQADPETEAIVMIGEIGGSAEEEAAEFIKMHVTKPVVSYIAGVTAP
KGKRMGHAGAIISGGKGTADEKFKTLENAGVKTVRSLAEIGSALRELLHK

Sequences:

>Translated_290_residues
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTKLVGGVSPNKGGTTHLGLPVFDTVREAVEKTGATASVIYVPAPGCKD
AILEAIDAGIQLIVCITEGIPTLDMICVKQKLKESGVRMIGPNCPGIITPDECKIGIMPAHIHKKGKIGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSSFIDILKLFQADPETEAIVMIGEIGGSAEEEAAEFIKMHVTKPVVSYIAGVTAP
KGKRMGHAGAIISGGKGTADEKFKTLENAGVKTVRSLAEIGSALRELLHK
>Mature_289_residues
AILIDKNTKVICQGFTGGQGTFHSEQALAYGTKLVGGVSPNKGGTTHLGLPVFDTVREAVEKTGATASVIYVPAPGCKDA
ILEAIDAGIQLIVCITEGIPTLDMICVKQKLKESGVRMIGPNCPGIITPDECKIGIMPAHIHKKGKIGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSSFIDILKLFQADPETEAIVMIGEIGGSAEEEAAEFIKMHVTKPVVSYIAGVTAPK
GKRMGHAGAIISGGKGTADEKFKTLENAGVKTVRSLAEIGSALRELLHK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=293, Percent_Identity=66.5529010238908, Blast_Score=331, Evalue=4e-91,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=32.6923076923077, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=32.6923076923077, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=84.375, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=65.9649122807018, Blast_Score=352, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=63.9175257731959, Blast_Score=345, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17557344, Length=256, Percent_Identity=28.90625, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17551266, Length=256, Percent_Identity=27.734375, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=52.8619528619529, Blast_Score=291, Evalue=8e-80,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=60.9756097560976, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI28574296, Length=285, Percent_Identity=63.859649122807, Blast_Score=331, Evalue=4e-91,
Organism=Drosophila melanogaster, GI281363477, Length=262, Percent_Identity=30.5343511450382, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363475, Length=262, Percent_Identity=30.5343511450382, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363473, Length=262, Percent_Identity=30.5343511450382, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30211; Mature: 30080

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTKLVGGVSPNKGGTTHLGLPVFDTVREA
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
VEKTGATASVIYVPAPGCKDAILEAIDAGIQLIVCITEGIPTLDMICVKQKLKESGVRMI
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
GPNCPGIITPDECKIGIMPAHIHKKGKIGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSSFIDILKLFQADPETEAIVMIGEIGGSAEEEAAEFIKMHVTKPVVSYIAGVTAP
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KGKRMGHAGAIISGGKGTADEKFKTLENAGVKTVRSLAEIGSALRELLHK
CCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AILIDKNTKVICQGFTGGQGTFHSEQALAYGTKLVGGVSPNKGGTTHLGLPVFDTVREA
EEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
VEKTGATASVIYVPAPGCKDAILEAIDAGIQLIVCITEGIPTLDMICVKQKLKESGVRMI
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
GPNCPGIITPDECKIGIMPAHIHKKGKIGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSSFIDILKLFQADPETEAIVMIGEIGGSAEEEAAEFIKMHVTKPVVSYIAGVTAP
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KGKRMGHAGAIISGGKGTADEKFKTLENAGVKTVRSLAEIGSALRELLHK
CCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]