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The map label for this gene is sucC

Identifier: 126207936

GI number: 126207936

Start: 520241

End: 521407

Strand: Reverse

Name: sucC

Synonym: APL_0452

Alternate gene names: 126207936

Gene position: 521407-520241 (Counterclockwise)

Preceding gene: 126207937

Following gene: 126207935

Centisome position: 22.92

GC content: 43.53

Gene sequence:

>1167_bases
ATGAATCTACACGAATATCAAGCAAAACAAATTTTTGCACAATATCGACTTCCCGTAAGTAAAGGTATTGTTTGTCATTC
TCTCGATGACGCCGTTTCAGCCATTCACACATTAGCAGGCGACACTTGGGCGGCGAAATGCCAAGTTCACGCCGGCGGTA
GAGGCAAAGCGGGCGGAGTAAAATTAGTGCGCAGTGAAGCGGAAATTCGTGAGTTTTGTAATCAATGGTTGGGACAGCGT
TTAGTCACTTTTCAAACCGATAAAAACGGACAACCGGTAAATACGATTTATCTCGAAGAAACGTGCCTAATAGAACGTGA
ATTATATTTGGGTGCAGTAATTGATCGTTCTTCACAAAAAATTGTTTTTATGGCATCAAATGCCGGCGGTATGAATATTG
AAGATGTCGCCGCACAAACACCGGAGCTTATCCATAAAGCAACCATTGATCCGCTTACCGGTGCGCAAGCTTTTCAGGGT
CGTGAATTAGCTTTTAAACTCGGTCTGTCCGGCGATCAAATCAAACAATTCGCTCATCTTTTTGTACAACTTGCCAAATT
ATTTATTGAAAAAGATCTTGCCTTACTCGAAGTAAATCCGCTCGTATTGACCAAACAAGGTCAATTACTTTGTTTAGATG
CCAAAATGGTAATTGACAGTAATGCTCTTTATCGCCATCCGGAGCTAAAAGCCCTACAAGATCCAAGCCAAGAAGATGCG
CGAGAAGCCGATGCGGCAAAATGGGATCTTAACTATGTCGCATTAGACGGCAATATCGGTTGTATGGTTAATGGTGCAGG
CTTAGCCATGGGAACCATGGATATCGTGAAACTACACGGTGGTCGTCCGGCAAACTTTTTAGATGTCGGCGGCGGCGCAA
CGAAAGAACGTGTTTCGGAAGCCTTTAAACTGATTCTTTCCGATCAGAATGTTAAAGCCGTCTTAGTCAATATTTTCGGC
GGCATCGTCAGATGCGATTTAATTGCGGAAGGTATTATTGCGGCGGTTAATGAAGTCGGGATAAACATTCCGGTCATCGT
GCGTTTAGAAGGTACTAATGCGGAATTAGGTCGTGAAATTTTAGCAAACAGCGGCTTACGTCTCATTGCGGCAAATACAT
TAACACAAGCGGCACAACTTGCAGTCAAAGCAGCGGAAGGAAAATAA

Upstream 100 bases:

>100_bases
TTTTTTGCCTATCTCCTCCTATTTTAACGTTTGCTTTTTTATAGTAGATGGATTAAATTCTTGAACATTATCCTAATCAT
TATCCTATACAGGAAAGCTT

Downstream 100 bases:

>100_bases
ACATGGCGATTTTAATTGATAAGAATACTAAAGTGATTTGCCAAGGTTTTACCGGCGGACAAGGCACATTTCATAGCGAA
CAGGCTTTAGCATACGGTAC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGVKLVRSEAEIREFCNQWLGQR
LVTFQTDKNGQPVNTIYLEETCLIERELYLGAVIDRSSQKIVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQG
RELAFKLGLSGDQIKQFAHLFVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDA
READAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSEAFKLILSDQNVKAVLVNIFG
GIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREILANSGLRLIAANTLTQAAQLAVKAAEGK

Sequences:

>Translated_388_residues
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGVKLVRSEAEIREFCNQWLGQR
LVTFQTDKNGQPVNTIYLEETCLIERELYLGAVIDRSSQKIVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQG
RELAFKLGLSGDQIKQFAHLFVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDA
READAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSEAFKLILSDQNVKAVLVNIFG
GIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREILANSGLRLIAANTLTQAAQLAVKAAEGK
>Mature_388_residues
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGVKLVRSEAEIREFCNQWLGQR
LVTFQTDKNGQPVNTIYLEETCLIERELYLGAVIDRSSQKIVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQG
RELAFKLGLSGDQIKQFAHLFVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDA
READAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSEAFKLILSDQNVKAVLVNIFG
GIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREILANSGLRLIAANTLTQAAQLAVKAAEGK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=393, Percent_Identity=47.0737913486005, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI157779135, Length=378, Percent_Identity=43.1216931216931, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI294862256, Length=362, Percent_Identity=43.0939226519337, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1786948, Length=388, Percent_Identity=67.5257731958763, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17567829, Length=389, Percent_Identity=43.1876606683805, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17539378, Length=393, Percent_Identity=43.0025445292621, Blast_Score=321, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6321683, Length=393, Percent_Identity=39.6946564885496, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI161078106, Length=393, Percent_Identity=43.5114503816794, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24645208, Length=393, Percent_Identity=43.5114503816794, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI281361397, Length=394, Percent_Identity=43.6548223350254, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI281361395, Length=394, Percent_Identity=43.6548223350254, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI21356231, Length=395, Percent_Identity=42.5316455696203, Blast_Score=310, Evalue=9e-85,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_ACTP2 (A3MZH0)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053161.1
- ProteinModelPortal:   A3MZH0
- SMR:   A3MZH0
- STRING:   A3MZH0
- GeneID:   4850531
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0452
- eggNOG:   COG0045
- HOGENOM:   HBG315432
- OMA:   RREFYFA
- PhylomeDB:   A3MZH0
- ProtClustDB:   PRK00696
- BioCyc:   APLE416269:APL_0452-MONOMER
- HAMAP:   MF_00558
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 41833; Mature: 41833

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGV
CCCHHHHHHHHHHHHCCCHHCCEEEECHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCE
KLVRSEAEIREFCNQWLGQRLVTFQTDKNGQPVNTIYLEETCLIERELYLGAVIDRSSQK
EEEECHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEHHHHHHHHHHEEHEEECCCCE
IVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQGRELAFKLGLSGDQIKQFAHL
EEEEECCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHCCCCEEEEEECCCHHHHHHHHHH
FVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDA
HHHHHHHHHHCCCEEEEECCEEEECCCCEEEEEEEEEECCCCEEECCCCHHHCCCCHHHH
READAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSE
HHHCCCEEEEEEEEECCCEEEEEECCCEEECCEEEEEECCCCCCCEEECCCCCCHHHHHH
AFKLILSDQNVKAVLVNIFGGIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LANSGLRLIAANTLTQAAQLAVKAAEGK
HHCCCCEEEEEHHHHHHHHHHHEECCCC
>Mature Secondary Structure
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGV
CCCHHHHHHHHHHHHCCCHHCCEEEECHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCE
KLVRSEAEIREFCNQWLGQRLVTFQTDKNGQPVNTIYLEETCLIERELYLGAVIDRSSQK
EEEECHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEHHHHHHHHHHEEHEEECCCCE
IVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQGRELAFKLGLSGDQIKQFAHL
EEEEECCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHCCCCEEEEEECCCHHHHHHHHHH
FVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDA
HHHHHHHHHHCCCEEEEECCEEEECCCCEEEEEEEEEECCCCEEECCCCHHHCCCCHHHH
READAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSE
HHHCCCEEEEEEEEECCCEEEEEECCCEEECCEEEEEECCCCCCCEEECCCCCCHHHHHH
AFKLILSDQNVKAVLVNIFGGIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHH
LANSGLRLIAANTLTQAAQLAVKAAEGK
HHCCCCEEEEEHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA