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The map label for this gene is pyrR

Identifier: 126207885

GI number: 126207885

Start: 455429

End: 455968

Strand: Reverse

Name: pyrR

Synonym: APL_0401

Alternate gene names: 126207885

Gene position: 455968-455429 (Counterclockwise)

Preceding gene: 126207886

Following gene: 126207884

Centisome position: 20.05

GC content: 41.85

Gene sequence:

>540_bases
ATGGAAAAAATTATTATTGATGCCGAGCAGTTTCAGCGTACGATTTCTCGGATTTCTCACCAAATTATCGAAAAACATTC
TTCCTTAGATAATTTGGTGTTAGTCGGGATAAAACGTCGCGGCGCTGAAATTGCCGAAATGTTACAAAGCAGGATTGCCG
AACTTGCTCAAACCGAATTGCCGTTAATGGCTTTAGATATTACATTTTATCGGGATGATCTTCATTTAGATCATCAAGAC
CCCGTTTATACCGGAGTGGAATCTCAAATTGATATTACCGGAAAAAATGTTATTCTGATCGATGACGTATTATTTACCGG
ACGTACGATTCGAGCCGCGCTTGATGCATTACTTGATTTTGGACGGGCAACACGTATAGAACTGGTCATTCTGGTCGATA
GAGGGCATCGCGAGTTACCAATCCGAGCCGATTATGTCGGAAAAAATATTCCGACCGCAAGAACGGAACAAGTACAAGTG
CGAACGCAATTTTACGACGGAATGAATCAAGTGGTGCTTATTCGAGCGAAAGACGAGTGA

Upstream 100 bases:

>100_bases
AAACGGCGGCGAAGTTAAAGTGTTAAATTTTGAGAACGGTTGTTCAACGACAAACGTAATCAAGAAAATTCAGGCGTCAA
AATAGGCTTTCTATCCACTA

Downstream 100 bases:

>100_bases
ATAAATACTAGGAACCTTTTTTAGAAAAATAGCTCTAATTATATCGGGGCTTATCTTTAACCTTTAGTAGGAAATAATAA
ATGAAATTAATCTCTGCAAA

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTELPLMALDITFYRDDLHLDHQD
PVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDFGRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQV
RTQFYDGMNQVVLIRAKDE

Sequences:

>Translated_179_residues
MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTELPLMALDITFYRDDLHLDHQD
PVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDFGRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQV
RTQFYDGMNQVVLIRAKDE
>Mature_179_residues
MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTELPLMALDITFYRDDLHLDHQD
PVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDFGRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQV
RTQFYDGMNQVVLIRAKDE

Specific function: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_ACTP2 (A3MZB9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053110.1
- ProteinModelPortal:   A3MZB9
- SMR:   A3MZB9
- STRING:   A3MZB9
- GeneID:   4849058
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0401
- eggNOG:   COG2065
- HOGENOM:   HBG641958
- OMA:   ELDITFF
- ProtClustDB:   PRK05205
- BioCyc:   APLE416269:APL_0401-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 20418; Mature: 20418

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTEL
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
PLMALDITFYRDDLHLDHQDPVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDF
CEEEEEEEEEECCCCCCCCCCEECCCCCEEEECCCCEEEEECHHHCCHHHHHHHHHHHHC
GRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQVRTQFYDGMNQVVLIRAKDE
CCCCEEEEEEEEECCCCCCCEEHHHCCCCCCCCCCHHHEEHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MEKIIIDAEQFQRTISRISHQIIEKHSSLDNLVLVGIKRRGAEIAEMLQSRIAELAQTEL
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
PLMALDITFYRDDLHLDHQDPVYTGVESQIDITGKNVILIDDVLFTGRTIRAALDALLDF
CEEEEEEEEEECCCCCCCCCCEECCCCCEEEECCCCEEEEECHHHCCHHHHHHHHHHHHC
GRATRIELVILVDRGHRELPIRADYVGKNIPTARTEQVQVRTQFYDGMNQVVLIRAKDE
CCCCEEEEEEEEECCCCCCCEEHHHCCCCCCCCCCHHHEEHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA