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The map label for this gene is hldE [H]

Identifier: 126207886

GI number: 126207886

Start: 455984

End: 457414

Strand: Reverse

Name: hldE [H]

Synonym: APL_0402

Alternate gene names: 126207886

Gene position: 457414-455984 (Counterclockwise)

Preceding gene: 126207887

Following gene: 126207885

Centisome position: 20.11

GC content: 45.0

Gene sequence:

>1431_bases
ATGATGATGCAATACTCTCCGAAATTTAATAACGCAAAAGTGCTTGTACTTGGCGATGTAATGTTAGACCGTTATTGGTT
TGGTGCAACCAACCGCATTTCGCCGGAAGCACCGGTGCCGGTGGTAAAAGTACAAGATATCGAAGAACGTGCCGGTGGTG
CGGCGAATGTGGCAATGAACATTGCCAGCCTTAGTGTACCGGTCGCCCTTCACGGTTTAATCGGGCAAGATGATGCCGGT
CGTGCTTTAGATAAATTACTTAATTCACATAATATCCAAAACCATTGTGTTGCATTGGATTCACACCCGACTATCACCAA
ATTACGTATTCTGTCACGTCATCAACAATTATTACGTTTAGATTTCGAAGAAGGCTTTCATCATGTCGCAAGCGATTCTC
TGCTTGCAAAACTTGAACAAGAAATTACCGCTTACGGTGCATTAATTTTATCGGATTACGGCAAAGGTACGCTTGAATCT
GTACAGCAAATGATTCAAGTGGCACGCAAAGCCGGCGTACCGACACTCATTGACCCGAAAGGTACCGATTTTGAACGTTA
CCGCGGTGCAACTCTCTTAACACCGAATATGTCGGAATTCGAAGCGGTAGTCGGCCACTGTAAAGATGACGATGAAATCG
TCGAGAAAGGCTTAAAACTGATTGCCGATTTTGAATTAACCGCATTATTAGTGACTCGTTCGGAAAAAGGTATGACGTTA
TTACGTCCGAACCAAGCACCGTTCCACTTACCGACCCAAGCGAAAGAGGTTTATGACGTAACCGGTGCCGGTGATACGGT
AATCAGTGTACTTGCGACTGCGATTGCCGACGGTCGCCCTTATGAGGAAGCGTGTTACTTAGCGAATGCGGCGGCAGGTG
TGGTTGTAGGCAAATTAGGTACTTCAACCGTCACACCAACCGAGTTAGAAAATGCGATTCATCATCGTGAAGAAACCGGT
TTCGGGATTTTAGCGGAAGACGAATTAAAACGTGCGGTAGAACAAGCAAAGCAACGTGGCGAAAAAATTGTGATGACCAA
CGGCTGTTTTGATATTCTGCACCCTGGTCACGTTTCTTATTTAGAAAATGCACGTAAATTAGGCGATCGTTTAATTGTGG
CGGTAAATACCGATGAATCGGTAAAACGCTTAAAAGGCGAATCTCGTCCGATTAACGATTTAAACGCACGTATGGCGGTG
CTTGCCGGTTTAGCCTCGGTGGATTGGGTCGTGCCTTTTGCAGAAGATACGCCGCAACGTCTTATCGGTGAAATCTTACC
TAACTTATTAGTCAAAGGTGGCGATTATAAGCCTGAAGAAATTGCCGGCAGCCAAGAAGTTTGGGCAAACGGCGGCGAAG
TTAAAGTGTTAAATTTTGAGAACGGTTGTTCAACGACAAACGTAATCAAGAAAATTCAGGCGTCAAAATAG

Upstream 100 bases:

>100_bases
CCCGACTTTATGTTAGCGCTCGGCTATAACGAGTGCTATCTAAATAAGGTTTAAGGCACTCGTCACAGACGAGCGCCATC
TTTTAATTGAGAAATTAACT

Downstream 100 bases:

>100_bases
GCTTTCTATCCACTAATGGAAAAAATTATTATTGATGCCGAGCAGTTTCAGCGTACGATTTCTCGGATTTCTCACCAAAT
TATCGAAAAACATTCTTCCT

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MMMQYSPKFNNAKVLVLGDVMLDRYWFGATNRISPEAPVPVVKVQDIEERAGGAANVAMNIASLSVPVALHGLIGQDDAG
RALDKLLNSHNIQNHCVALDSHPTITKLRILSRHQQLLRLDFEEGFHHVASDSLLAKLEQEITAYGALILSDYGKGTLES
VQQMIQVARKAGVPTLIDPKGTDFERYRGATLLTPNMSEFEAVVGHCKDDDEIVEKGLKLIADFELTALLVTRSEKGMTL
LRPNQAPFHLPTQAKEVYDVTGAGDTVISVLATAIADGRPYEEACYLANAAAGVVVGKLGTSTVTPTELENAIHHREETG
FGILAEDELKRAVEQAKQRGEKIVMTNGCFDILHPGHVSYLENARKLGDRLIVAVNTDESVKRLKGESRPINDLNARMAV
LAGLASVDWVVPFAEDTPQRLIGEILPNLLVKGGDYKPEEIAGSQEVWANGGEVKVLNFENGCSTTNVIKKIQASK

Sequences:

>Translated_476_residues
MMMQYSPKFNNAKVLVLGDVMLDRYWFGATNRISPEAPVPVVKVQDIEERAGGAANVAMNIASLSVPVALHGLIGQDDAG
RALDKLLNSHNIQNHCVALDSHPTITKLRILSRHQQLLRLDFEEGFHHVASDSLLAKLEQEITAYGALILSDYGKGTLES
VQQMIQVARKAGVPTLIDPKGTDFERYRGATLLTPNMSEFEAVVGHCKDDDEIVEKGLKLIADFELTALLVTRSEKGMTL
LRPNQAPFHLPTQAKEVYDVTGAGDTVISVLATAIADGRPYEEACYLANAAAGVVVGKLGTSTVTPTELENAIHHREETG
FGILAEDELKRAVEQAKQRGEKIVMTNGCFDILHPGHVSYLENARKLGDRLIVAVNTDESVKRLKGESRPINDLNARMAV
LAGLASVDWVVPFAEDTPQRLIGEILPNLLVKGGDYKPEEIAGSQEVWANGGEVKVLNFENGCSTTNVIKKIQASK
>Mature_476_residues
MMMQYSPKFNNAKVLVLGDVMLDRYWFGATNRISPEAPVPVVKVQDIEERAGGAANVAMNIASLSVPVALHGLIGQDDAG
RALDKLLNSHNIQNHCVALDSHPTITKLRILSRHQQLLRLDFEEGFHHVASDSLLAKLEQEITAYGALILSDYGKGTLES
VQQMIQVARKAGVPTLIDPKGTDFERYRGATLLTPNMSEFEAVVGHCKDDDEIVEKGLKLIADFELTALLVTRSEKGMTL
LRPNQAPFHLPTQAKEVYDVTGAGDTVISVLATAIADGRPYEEACYLANAAAGVVVGKLGTSTVTPTELENAIHHREETG
FGILAEDELKRAVEQAKQRGEKIVMTNGCFDILHPGHVSYLENARKLGDRLIVAVNTDESVKRLKGESRPINDLNARMAV
LAGLASVDWVVPFAEDTPQRLIGEILPNLLVKGGDYKPEEIAGSQEVWANGGEVKVLNFENGCSTTNVIKKIQASK

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=470, Percent_Identity=72.1276595744681, Blast_Score=702, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51799; Mature: 51799

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMQYSPKFNNAKVLVLGDVMLDRYWFGATNRISPEAPVPVVKVQDIEERAGGAANVAMN
CCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHCCCCHHHEEE
IASLSVPVALHGLIGQDDAGRALDKLLNSHNIQNHCVALDSHPTITKLRILSRHQQLLRL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
DFEEGFHHVASDSLLAKLEQEITAYGALILSDYGKGTLESVQQMIQVARKAGVPTLIDPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCC
GTDFERYRGATLLTPNMSEFEAVVGHCKDDDEIVEKGLKLIADFELTALLVTRSEKGMTL
CCCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEE
LRPNQAPFHLPTQAKEVYDVTGAGDTVISVLATAIADGRPYEEACYLANAAAGVVVGKLG
ECCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCC
TSTVTPTELENAIHHREETGFGILAEDELKRAVEQAKQRGEKIVMTNGCFDILHPGHVSY
CCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCHHHH
LENARKLGDRLIVAVNTDESVKRLKGESRPINDLNARMAVLAGLASVDWVVPFAEDTPQR
HHHHHHCCCEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHH
LIGEILPNLLVKGGDYKPEEIAGSQEVWANGGEVKVLNFENGCSTTNVIKKIQASK
HHHHHHHHHHCCCCCCCHHHHCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MMMQYSPKFNNAKVLVLGDVMLDRYWFGATNRISPEAPVPVVKVQDIEERAGGAANVAMN
CCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHCCCCHHHEEE
IASLSVPVALHGLIGQDDAGRALDKLLNSHNIQNHCVALDSHPTITKLRILSRHQQLLRL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
DFEEGFHHVASDSLLAKLEQEITAYGALILSDYGKGTLESVQQMIQVARKAGVPTLIDPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCC
GTDFERYRGATLLTPNMSEFEAVVGHCKDDDEIVEKGLKLIADFELTALLVTRSEKGMTL
CCCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEE
LRPNQAPFHLPTQAKEVYDVTGAGDTVISVLATAIADGRPYEEACYLANAAAGVVVGKLG
ECCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCC
TSTVTPTELENAIHHREETGFGILAEDELKRAVEQAKQRGEKIVMTNGCFDILHPGHVSY
CCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCHHHH
LENARKLGDRLIVAVNTDESVKRLKGESRPINDLNARMAVLAGLASVDWVVPFAEDTPQR
HHHHHHCCCEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHH
LIGEILPNLLVKGGDYKPEEIAGSQEVWANGGEVKVLNFENGCSTTNVIKKIQASK
HHHHHHHHHHCCCCCCCHHHHCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA