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The map label for this gene is recQ [H]

Identifier: 126176528

GI number: 126176528

Start: 5086759

End: 5088858

Strand: Reverse

Name: recQ [H]

Synonym: Sbal_4347

Alternate gene names: 126176528

Gene position: 5088858-5086759 (Counterclockwise)

Preceding gene: 126176529

Following gene: 126176527

Centisome position: 99.25

GC content: 48.0

Gene sequence:

>2100_bases
ATGAATAGAGATCAAGCTAAGCTCCACCTGCAAACTGCTTTGGCAAATACTGACGCCGATTTCCGTGATGGCCAATGGGA
AGCGATTGATGCTCTGGTCAATCATCGGCAGAAATTGTTAGTGGTGCAGCGTACAGGTTGGGGTAAAAGCTCGGTTTACT
TTATCAGTACCAAAATTTTTCGTGATCGCGGCATGGGGCCAACCATTATCGTTTCGCCTTTGCTGGCGTTGATGCGCAAT
CAGATTGAATCTGCCGCGCGTTTAGGTATCGTTGCTGAAACCATGAACTCCACGAATACCGCTGATTGGCAGGCGGTTAC
TCAACGGATTCTTAATAATCAAATCGATTGTTTGCTGATTTCTCCTGAGCGGCTGGCCAACGATAACTTCATTGAAACCG
TCTTACAGCCTATTGCCGACCGTATCGCCCTGATGGTGATTGATGAGGCGCACTGTATTTCTGATTGGGGCCACGACTTC
CGCCCCGACTATCGCCGTATAGTAAATATCCTGCGCCAGCTACCCGCTAACACACCGGTTTTAGGCACCACTGCGACCGC
GAATAACCGCGTAGTAGCCGATATTCAAACCCAGGTTGGTGACATTCAAATCCACCGTGGCCCGTTAACTCGCGAAAGCC
TTGCCCTACAAACCATGGTGTTACCCGATCAGGCGTCTCGCTTGGCCTGGTTAGTTCAAGTCATTCCAACTTTACCGGGT
ACGGGGATTGTTTACACATTAACAGTGCCCGATGCAGAGCAGGTAGCTAACTGGCTCACTAATAATGGTATTGATGCTAA
GGCTTATCATGGCAGCGTAGAGGCAGAAGGCTTTGAAAATAGCAATACGTATCGCCAGCACTTAGAAGAGTTGTTACTCA
ACAATCGGTTAAAGGTGTTAGTCGCCACTACAGCCTTGGGTATGGGCTACGATAAACCGGATTTAAGTTTTGTTATTCAC
TACCAAGCGCCGGGCTCTATCGTTGGTTATTATCAGCAGGTAGGCCGAGCAGGGCGTGGTATTGACCATGCTGTTGGCGT
ATTGATGTCTGGTGTGGAAGATCAGGATATTCATGAATTTTTCCGCGAGTCGGCGTTCCCATCTGAGGCACAGGTGAATG
AAATTTTACACGTACTGGAACAAAGCGATGGTTTGTCATTGCGCAGTATTGAAGAGCAAACCAACCTGCGTCACGGTCAA
ATTGAGAAAGTTCTTAAATTATTGAGTGTGGAAAACCCGGCTCCTGTAATCAAAGACGGCAGCCGTTGGTTCAGAACTCC
TGTTCGATATCAAATGGATCATGCCCGAATCGCTCATTTAACAGGCCAGCGTGTTCAGGAATGGCAAGAAGTTCAGGCAT
ACCTTGCAGATACTGATTGTAAGATGACCTTCCTTCGCCGAGCGCTGGACGATTTTGATCCAACGCCCTGCGGTAAGTGC
GCATCTTGTGTTGGTCGGCTCGTTATCAATATTCCGGTAGATCCTAGTTTGGCGCATCGTGCGGGGACCTTTCTTAAACA
CGCCGAAATGGTAATTAGTCCAAAAGCACAGGTCGCAGCCAATGCGTTTTTAGAATACGGCTTTCGTGGTAACCTCCCAC
TTAACCTTCGAGCACAAGAAGGGCGTGTTTTATCGCGCTGGGGCGATGCTGGTTGGGGGCACATGGTAGCGGACAACAAG
CATGCTGGACGGTTCATTGATGAATTAGTCGAAGCCATGGTTGAAATGGTTCAACAGCGCTGGCAGCCTAATCCTGCACC
TCAGTGGATATGCTGCGTACCTTCTCGGAACCATCCAGAACTGGTGCCAGATTTTGCTCGCAGACTAGCAATTCGTTTAG
GCCTACCTTTTGTTGATGCTGTAAGTAAAGTAAAAGACAATCAACAGCAAAAAGGGCAGCAAAATCGGTTCCATCAATGT
CGTAATTTGGATGGGGCATTTGCTGTTAATCAAGATATCCCAACTACTCCAGTGTTACTTGTTGATGACATAGTAGATTC
TGGTTGGACGCTGACCGTTATATCAGCATTATTACAACAAGCAGGTAGCGGTGTAGTGTATCCCGTGGCACTTGCTTCCT
CTTCGGTGAAAGACTCATGA

Upstream 100 bases:

>100_bases
AACTTACAGGACTACAACAATAAGCTTGCTCAAGCTCGAGACTTGTTACTACCTAAACTAATGAGCGGCGAACTGACCGT
GTAATCAAAGGACTGATGAA

Downstream 100 bases:

>100_bases
ATTTATCGCCAACGGCTCAAGCAACATTACTACTTACTTGTTATTTTTCCAAAGCGAGTAACGAAAATGCTAAACCCCTT
ACAAATGCTGAATGGGGCCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MNRDQAKLHLQTALANTDADFRDGQWEAIDALVNHRQKLLVVQRTGWGKSSVYFISTKIFRDRGMGPTIIVSPLLALMRN
QIESAARLGIVAETMNSTNTADWQAVTQRILNNQIDCLLISPERLANDNFIETVLQPIADRIALMVIDEAHCISDWGHDF
RPDYRRIVNILRQLPANTPVLGTTATANNRVVADIQTQVGDIQIHRGPLTRESLALQTMVLPDQASRLAWLVQVIPTLPG
TGIVYTLTVPDAEQVANWLTNNGIDAKAYHGSVEAEGFENSNTYRQHLEELLLNNRLKVLVATTALGMGYDKPDLSFVIH
YQAPGSIVGYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEFFRESAFPSEAQVNEILHVLEQSDGLSLRSIEEQTNLRHGQ
IEKVLKLLSVENPAPVIKDGSRWFRTPVRYQMDHARIAHLTGQRVQEWQEVQAYLADTDCKMTFLRRALDDFDPTPCGKC
ASCVGRLVINIPVDPSLAHRAGTFLKHAEMVISPKAQVAANAFLEYGFRGNLPLNLRAQEGRVLSRWGDAGWGHMVADNK
HAGRFIDELVEAMVEMVQQRWQPNPAPQWICCVPSRNHPELVPDFARRLAIRLGLPFVDAVSKVKDNQQQKGQQNRFHQC
RNLDGAFAVNQDIPTTPVLLVDDIVDSGWTLTVISALLQQAGSGVVYPVALASSSVKDS

Sequences:

>Translated_699_residues
MNRDQAKLHLQTALANTDADFRDGQWEAIDALVNHRQKLLVVQRTGWGKSSVYFISTKIFRDRGMGPTIIVSPLLALMRN
QIESAARLGIVAETMNSTNTADWQAVTQRILNNQIDCLLISPERLANDNFIETVLQPIADRIALMVIDEAHCISDWGHDF
RPDYRRIVNILRQLPANTPVLGTTATANNRVVADIQTQVGDIQIHRGPLTRESLALQTMVLPDQASRLAWLVQVIPTLPG
TGIVYTLTVPDAEQVANWLTNNGIDAKAYHGSVEAEGFENSNTYRQHLEELLLNNRLKVLVATTALGMGYDKPDLSFVIH
YQAPGSIVGYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEFFRESAFPSEAQVNEILHVLEQSDGLSLRSIEEQTNLRHGQ
IEKVLKLLSVENPAPVIKDGSRWFRTPVRYQMDHARIAHLTGQRVQEWQEVQAYLADTDCKMTFLRRALDDFDPTPCGKC
ASCVGRLVINIPVDPSLAHRAGTFLKHAEMVISPKAQVAANAFLEYGFRGNLPLNLRAQEGRVLSRWGDAGWGHMVADNK
HAGRFIDELVEAMVEMVQQRWQPNPAPQWICCVPSRNHPELVPDFARRLAIRLGLPFVDAVSKVKDNQQQKGQQNRFHQC
RNLDGAFAVNQDIPTTPVLLVDDIVDSGWTLTVISALLQQAGSGVVYPVALASSSVKDS
>Mature_699_residues
MNRDQAKLHLQTALANTDADFRDGQWEAIDALVNHRQKLLVVQRTGWGKSSVYFISTKIFRDRGMGPTIIVSPLLALMRN
QIESAARLGIVAETMNSTNTADWQAVTQRILNNQIDCLLISPERLANDNFIETVLQPIADRIALMVIDEAHCISDWGHDF
RPDYRRIVNILRQLPANTPVLGTTATANNRVVADIQTQVGDIQIHRGPLTRESLALQTMVLPDQASRLAWLVQVIPTLPG
TGIVYTLTVPDAEQVANWLTNNGIDAKAYHGSVEAEGFENSNTYRQHLEELLLNNRLKVLVATTALGMGYDKPDLSFVIH
YQAPGSIVGYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEFFRESAFPSEAQVNEILHVLEQSDGLSLRSIEEQTNLRHGQ
IEKVLKLLSVENPAPVIKDGSRWFRTPVRYQMDHARIAHLTGQRVQEWQEVQAYLADTDCKMTFLRRALDDFDPTPCGKC
ASCVGRLVINIPVDPSLAHRAGTFLKHAEMVISPKAQVAANAFLEYGFRGNLPLNLRAQEGRVLSRWGDAGWGHMVADNK
HAGRFIDELVEAMVEMVQQRWQPNPAPQWICCVPSRNHPELVPDFARRLAIRLGLPFVDAVSKVKDNQQQKGQQNRFHQC
RNLDGAFAVNQDIPTTPVLLVDDIVDSGWTLTVISALLQQAGSGVVYPVALASSSVKDS

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=331, Percent_Identity=34.441087613293, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI14591902, Length=346, Percent_Identity=32.6589595375723, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI14591904, Length=346, Percent_Identity=32.6589595375723, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI51242943, Length=332, Percent_Identity=33.1325301204819, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI51242947, Length=332, Percent_Identity=33.1325301204819, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI148612816, Length=400, Percent_Identity=31, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI284005309, Length=361, Percent_Identity=29.9168975069252, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI169218196, Length=341, Percent_Identity=28.4457478005865, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI110735439, Length=341, Percent_Identity=28.4457478005865, Blast_Score=127, Evalue=5e-29,
Organism=Escherichia coli, GI48994977, Length=325, Percent_Identity=36.6153846153846, Blast_Score=183, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25145561, Length=335, Percent_Identity=35.8208955223881, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71987997, Length=359, Percent_Identity=33.1476323119777, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71987993, Length=359, Percent_Identity=33.1476323119777, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17552866, Length=360, Percent_Identity=32.2222222222222, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32564293, Length=372, Percent_Identity=28.7634408602151, Blast_Score=155, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323844, Length=342, Percent_Identity=30.4093567251462, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646066, Length=345, Percent_Identity=33.6231884057971, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24664230, Length=343, Percent_Identity=31.4868804664723, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI62472181, Length=343, Percent_Identity=31.4868804664723, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24664226, Length=343, Percent_Identity=31.4868804664723, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI21358123, Length=357, Percent_Identity=31.0924369747899, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77806; Mature: 77806

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00690 DEAH_ATP_HELICASE ; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDQAKLHLQTALANTDADFRDGQWEAIDALVNHRQKLLVVQRTGWGKSSVYFISTKIF
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEHH
RDRGMGPTIIVSPLLALMRNQIESAARLGIVAETMNSTNTADWQAVTQRILNNQIDCLLI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEE
SPERLANDNFIETVLQPIADRIALMVIDEAHCISDWGHDFRPDYRRIVNILRQLPANTPV
CHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
LGTTATANNRVVADIQTQVGDIQIHRGPLTRESLALQTMVLPDQASRLAWLVQVIPTLPG
EEEECCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHEECCCHHHHHHHHHHHHHCCCC
TGIVYTLTVPDAEQVANWLTNNGIDAKAYHGSVEAEGFENSNTYRQHLEELLLNNRLKVL
CCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE
VATTALGMGYDKPDLSFVIHYQAPGSIVGYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEF
EEEHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
FRESAFPSEAQVNEILHVLEQSDGLSLRSIEEQTNLRHGQIEKVLKLLSVENPAPVIKDG
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
SRWFRTPVRYQMDHARIAHLTGQRVQEWQEVQAYLADTDCKMTFLRRALDDFDPTPCGKC
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHH
ASCVGRLVINIPVDPSLAHRAGTFLKHAEMVISPKAQVAANAFLEYGFRGNLPLNLRAQE
HHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
GRVLSRWGDAGWGHMVADNKHAGRFIDELVEAMVEMVQQRWQPNPAPQWICCVPSRNHPE
CCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
LVPDFARRLAIRLGLPFVDAVSKVKDNQQQKGQQNRFHQCRNLDGAFAVNQDIPTTPVLL
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCCCEEECCCCCCCCEEE
VDDIVDSGWTLTVISALLQQAGSGVVYPVALASSSVKDS
EEHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNRDQAKLHLQTALANTDADFRDGQWEAIDALVNHRQKLLVVQRTGWGKSSVYFISTKIF
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEHH
RDRGMGPTIIVSPLLALMRNQIESAARLGIVAETMNSTNTADWQAVTQRILNNQIDCLLI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEE
SPERLANDNFIETVLQPIADRIALMVIDEAHCISDWGHDFRPDYRRIVNILRQLPANTPV
CHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
LGTTATANNRVVADIQTQVGDIQIHRGPLTRESLALQTMVLPDQASRLAWLVQVIPTLPG
EEEECCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHEECCCHHHHHHHHHHHHHCCCC
TGIVYTLTVPDAEQVANWLTNNGIDAKAYHGSVEAEGFENSNTYRQHLEELLLNNRLKVL
CCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE
VATTALGMGYDKPDLSFVIHYQAPGSIVGYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEF
EEEHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
FRESAFPSEAQVNEILHVLEQSDGLSLRSIEEQTNLRHGQIEKVLKLLSVENPAPVIKDG
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
SRWFRTPVRYQMDHARIAHLTGQRVQEWQEVQAYLADTDCKMTFLRRALDDFDPTPCGKC
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHH
ASCVGRLVINIPVDPSLAHRAGTFLKHAEMVISPKAQVAANAFLEYGFRGNLPLNLRAQE
HHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
GRVLSRWGDAGWGHMVADNKHAGRFIDELVEAMVEMVQQRWQPNPAPQWICCVPSRNHPE
CCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
LVPDFARRLAIRLGLPFVDAVSKVKDNQQQKGQQNRFHQCRNLDGAFAVNQDIPTTPVLL
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCCCEEECCCCCCCCEEE
VDDIVDSGWTLTVISALLQQAGSGVVYPVALASSSVKDS
EEHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]